Human 5-HT(1B) receptor stimulated inositol phospholipid hydrolysis in CHO cells: Synergy with G(q)-coupled receptors

European Journal of Pharmacology

Volumn 348, Issue 2-3, 1998, Pages 279-285

  Dickenson, John M ^a,b   Hill, Stephen J ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b NOTTINGHAM TRENT UNIVERSITY   (United Kingdom)

Author keywords

5 HT(1B) receptor; CHO cell; Inositol phosphate; P(2U) purinoceptor

Indexed keywords

ADENINE; ADENOSINE A1 RECEPTOR; CYCLIC AMP; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL; INOSITOL PHOSPHATE; PERTUSSIS TOXIN; PURINE P2Y2 RECEPTOR; SEROTONIN 1B RECEPTOR; SUMATRIPTAN; COMPLEMENTARY DNA; HTR1B PROTEIN, HUMAN; SEROTONIN AGONIST; SEROTONIN RECEPTOR;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; HYDROLYSIS; MUSCLE CONTRACTION; NONHUMAN; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; RECEPTOR DENSITY; SECOND MESSENGER; VASCULAR SMOOTH MUSCLE; ANIMAL; DOSE RESPONSE; DRUG EFFECT; GENETICS; HAMSTER; HUMAN; METABOLISM; PHYSIOLOGY;

ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; FORSKOLIN; GTP-BINDING PROTEINS; HUMANS; HYDROLYSIS; INOSITOL PHOSPHATES; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, SEROTONIN; SECOND MESSENGER SYSTEMS; SEROTONIN AGONISTS; SUMATRIPTAN;

EID: 0032495870     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00148-4     Document Type: Article

References (33)

1. Berg K.A., Clarke W.P., Sailstad C., Saltzman A., Maayani S. Signal transduction differences between 5-hydroxytrptamine type 2A and type 2C receptor systems. Mol. Pharmacol. 46:1994;477-484.
2. Berridge M.J. Inositol trisphosphate and calcium signalling. Nature. 361:1993;315-325.
3. Boess F.G., Martin I.L. Molecular biology of 5-HT receptors. Neuropharmacology. 33:1994;275-317.
4. Bouchelet I., Cohen Z., Case B., Seguela P., Hamel E. Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels. Mol. Pharmacol. 50:1996;219-223.
5. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
6. 1-like receptors revealed by precontraction of rabbit isolated mesenteric artery. Br. J. Pharmacol. 114:1995;309-314.
7. 1-like receptor agonist sumatriptan in anaesthetised rats. Eur. J. Pharmacol. 304:1996;87-92.
8. 1 receptor Eur. J. Pharmacol. 268:1994;257-262.
9. 1B-like receptor to increases in intracellular calcium through a pertussis toxin-sensitive mechanism in CHO-K1 cells. Br. J. Pharmacol. 116:1995;2889-2896.
10. 1 receptors and endogenous cholecystokinin receptors in CHO cells. Eur. J. Pharmacol. 302:1996;141-151.
11. 2 activity in CHO cells. Eur. J. Pharmacol. 321:1997;77-86.
12. 1-like receptors linked to increases in intracellular calcium concentration and inhibition of cyclic AMP accumulation in cultured vascular smooth muscle cells derived from bovine basilar artery. J. Pharmacol. Exp. Ther. 266:1993;692-699.
13. 1 and bradykinin receptors increases protein kinase C and phospholipase D activity in smooth muscle cells. Naunyn-Schmiedebergs Arch. Pharmacol. 351:1995;186-193.
14. 1B receptor in CHO cells: functional responses in the absence of radioligand binding. Br. J. Pharmacol. 117:1996;1119-1126.
15. 1Dβ receptor subtype in human and bovine cerebral arteries. Mol. Pharmacol. 44:1993;242-249.
16. 1D receptor subtypes. Trends Pharmacol. Sci. 17:1996;103-105.
17. Hervé P., Drouet L., Dosquet C., Launay J-M., Rain B., Simonneau G., Caen J., Duroux P. Primary pulmonary hypertension in a patient with familial storage pool disease: role of serotonin. Am. J. Med. 89:1990;117-120.
18. Hervé P., Launay J-M., Scrobohaci M-L., Brenot F., Simonneau G., Petitpretz P., Poubeau P., Cerrina J., Duroux P., Drouet L. Increased plasma serotonin in primary pulmonary hypertension. Am. J. Med. 99:1995;249-254.
19. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., Humphrey P.P.A. VII. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46:1994;157-203.
20. 1 receptor in CHO-K1 cells to calcium mobilisation via a pertussis toxin-sensitive mechanism. Br. J. Pharmacol. 111:1994;1252-1256.
21. 1-like receptor-mediated vasoconstriction in human pulmonary artery. Br. J. Pharmacol. 119:1996;277-282.
22. MacLennan S.J., Bolofo M.L., Martin G.R. Amplifying interactions between spasmogens in vascular smooth muscle. Biochem. Soc. Trans. 21:1993;1145-1150.
23. 1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole. J. Med. Chem. 33:1990;2087-2093.
24. 2-purinoceptors in CHO-K1 cells. Br. J. Pharmacol. 115:1995;1415-1424.
25. Nishimura Y. Characterization of 5-hydroxytryptamine receptors mediating contractions in basilar arteries from stroke-prone spontaneously hypertensive rats. Br. J. Pharmacol. 117:1996;1325-1333.
26. 1B receptors. J. Neurochem. 60:1993;380-383.
27. 1B receptors inhibiting cyclic AMP accumulation in rat renal mesangial cells. Naunyn-Schmiedebergs Arch. Pharmacol. 351:1995;35-39.
28. 1b-adrenergic receptors in the regulation of phospholipase C, protein kinase C and arachidonic acid production. J. Biol. Chem. 270:1995;11789-11796.
29. 1 receptors in vascular smooth muscle. Br. J. Pharmacol. 117:1996;250P.
30. 1-like receptor mediating contraction in the canine coronary artery. Eur. J. Pharmacol. 300:1996;109-112.
31. Ullmer C., Schmuck K., Kalkman H.O., Lubbert H. Expression of serotonin receptor mRNAs in blood vessels. FEBS Lett. 370:1995;215-221.
32. 1Dβ receptors stably expressed in murine fibroblasts: inhibition of adenylate cyclase and elevation of intracellular calcium concentrations via pertussis toxin-sensitive G protein(s). Mol. Pharmacol. 44:1993;575-582.
33. 1D subtypes. Naunyn-Schmiedebergs Arch. Pharmacol. 354:1996;226-236.