Real-time isoform analysis by two-dimensional chromatography of a monoclonal antibody during bioreactor fermentations

Journal of Chromatography A

Volumn 816, Issue 1, 1998, Pages 39-47

  Fang, Yu ^a   Dumont, Larry ^a   Larsen, Brent ^a  

^a PROTEIN DESIGN LABS INC   (United States)

Author keywords

Monoclonal antibodies; Proteins

Indexed keywords

L SELECTIN; MONOCLONAL ANTIBODY; PROTEIN; PROTEIN A;

AFFINITY CHROMATOGRAPHY; ARTICLE; BIOREACTOR; CHROMATOGRAPHY; DRUG MANUFACTURE; FERMENTATION; HUMAN; ION EXCHANGE CHROMATOGRAPHY; PRIORITY JOURNAL; PROTEIN ANALYSIS; SUPERNATANT;

ANTIBODIES, MONOCLONAL; CELLS, CULTURED; CHROMATOGRAPHY, AFFINITY; FERMENTATION; HUMANS; ISOMERISM; RECOMBINANT PROTEINS; SOLVENTS;

EID: 0032493787     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(98)00032-6     Document Type: Article

References (14)

1. Berg E.L., Goldstein L.A., Jutila M.A., Nakache M., Picker L.J., Streeter P.R., Wu N.W., Zhou D., Butcher E.C. Immunol. Rev. 108:1989;5.
2. Kansas G.S. Blood. 88:1996;3259.
3. M.L. Hagmann, personal communication.
4. Huttner W.B. Ann. Rev. Physiol. 50:1988;363.
5. Curling E.M.A., Hayter P.M., Baines A.J., Bull A.T., Gull K., Strange P.G., Jenkins N. Biochem. J. 272:1990;333.
6. Hooker A.D., Goldman M.H., Markham M.H., James D.C., Ison A.P., Bull A.T., Strange P.G., Salmon I., Baines A.J., Jenkins N. Biotechnol. Bioeng. 48:1995;639.
7. Gu X., Xie L., Harmon B.J., Wang D.I.C. Biotechnol. Bioeng. 56:1997;354.
8. Xie L., Nyberg G., Gu X., Li H., Möllborn F., Wang D.I.C. Biotechnol. Bioeng. 56:1997;578.
9. Patel T.P., Parekh R.B., Mollering B.J., Prior C.P. Biochem. J. 285:1992;839.
10. Lund J., Takahashi N., Nakagawa H., Goodall M., Bentley T., Hindley S.A., Tyler R., Jefferis R. Mol. Immunol. 30:1993;741.
11. Monica T.J., Goochee C.F., Maiorella B.L. Biotechnology. 11:1993;512.
12. James D.C., Freedman R.B., Hoare M., Jenkins N. Anal. Biochem. 22:1994;315.
13. B.H. O'Connor, N. Pathmanabhan, B.R. Larsen, presented at the 13th International Symposium on High-Performance Liquid Chromatography of Proteins, Peptides and Polynucleotides, San Francisco, CA, 30 November-3 December 1993, abstract 109.
14. Nadler T.K., Paliwal S.K., Regnier F.E. J. Chromatogr. A. 676:1994;331.