Geometrically directed selective steroid hydroxylation with high turnover by a fluorinated artificial cytochrome P-450

Tetrahedron Letters

Volumn 39, Issue 19, 1998, Pages 2887-2890

  Breslow, Ronald ^a   Gabriele, Bartolo ^a,b   Yang, Jerry ^a  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF CALABRIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIOL DERIVATIVE; CYTOCHROME P450; MANGANESE; METALLOPORPHYRIN; STEROID; TETRAPHENYLPORPHYRIN DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL REACTION; ENZYME ACTIVITY; ENZYME SUBSTRATE; HYDROXYLATION; STEROID HYDROXYLATION;

EID: 0032493050     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00425-0     Document Type: Article

References (9)

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3. 3. Breslow, R.; Huang, Y.; Zhang, X.; Yang, J. Proc. Natl. Acad. Sci. USA 1997, 94, 11156.
4. 4. The hydroxylation of 2 by catalyst 1 was complete is 45 min. at room temp. The hydroxylation of 5 by catalyst 8 was allowed to proceed for 4h; addition of an additional 10 equiv of oxidant and a further 2h standing did not increase the substrate conversion, indicating that catalyst lifetime is the limiting factor.
5. 5. Ellis, P. E.; Lyons, J. E. Coord. Chem. Rev. 1990, 105, 181-193.
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