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Volumn 36, Issue 24, 1997, Pages 2794-2797

Synthesis of an ABC Ring Analogue of Kapurimycin A3 as an Effective DNA Alkylating Agent

Author keywords

Alkylations; Antitumor agents; DNA cleavage; Drug design

Indexed keywords


EID: 0032491784     PISSN: 05700833     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.199727941     Document Type: Article
Times cited : (16)

References (26)
  • 17
    • 0642315510 scopus 로고    scopus 로고
    • note
    • The E and Z isomers could not be separated throughout the synthesis.
  • 20
    • 0642285021 scopus 로고    scopus 로고
    • note
    • The relative configuration of the two asymmetric centers in 11 was confirmed by the presence of an NOE between C12-Me and C14-H.
  • 22
    • 0642376915 scopus 로고    scopus 로고
    • note
    • The absolute configuration of 5 was determined to be 11S and 13R by a modified Mosher method [14] applied for the MTPA ester of 5.
  • 24
    • 85045587631 scopus 로고    scopus 로고
    • note
    • N2 mechanism.
  • 26
    • 0642376917 scopus 로고    scopus 로고
    • note
    • Further evidence for alkylation of guanine by 2 was obtained by sequencing analysis. Thus, smear cleavage bands obtained by heating DNA treated with 2 did not co-migrate with Maxam-Gilbert G bands, whereas the clear G bands in Figure 4 were obtained by heating the same samples with piperidine. The observed band shift is a typical indication for alkylation of guanine at N7.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.