N-tosyl-L-phenylalanine chloromethyl ketone, a serine protease inhibitor, identifies glutamate 398 at the coenzyme-binding site of human aldehyde dehydrogenase. Evidence for a second 'naked anion' at the active site

Biochemistry

Volumn 37, Issue 40, 1998, Pages 14151-14156

  Dryjanski, Marek ^a   Kosley, Lynda L ^a   Pietruszko, Regina ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; CHYMOTRYPSIN; GLUTAMIC ACID; SERINE PROTEINASE INHIBITOR; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; TRYPSIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANION TRANSPORT; ARTICLE; CHEMICAL MODIFICATION; COVALENT BOND; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PURIFICATION; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ALDEHYDE DEHYDROGENASE; AMINO ACID SEQUENCE; BINDING SITES; CHYMOTRYPSIN; CYTOPLASM; GLUTAMIC ACID; HUMANS; ISOENZYMES; KINETICS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; NAD; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; SERINE PROTEINASE INHIBITORS; SUBSTRATE SPECIFICITY; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; TRYPSIN;

EID: 0032491157     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi981278v     Document Type: Article

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