A novel three-step hydroxy-deamination sequence: Conversion of lysine to 6-hydroxynorleucine derivatives

Tetrahedron Letters

Volumn 39, Issue 32, 1998, Pages 5671-5674

  Nevill Jr , C Richard ^a   Angell, Paul T ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXYNORLEUCINE DERIVATIVE; ALPHA AMINO ACID; LYSINE; NORLEUCINE; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DEAMINATION; OXIDATION; STOICHIOMETRY;

EID: 0032490878     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01142-3     Document Type: Article

References (20)

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16. 10. This experiment utilized 5c as a starting material.
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19. 12. Compounds 8d and 8e contained an equivalent of corresponding carbamate (ethyl or i-butyl) which is a by-product of the reduction and was difficult to remove, unlike the t-butyl carbamate formed during reductions of 6a-c which could be removed by sublimation.
20. 2, rt, 2 h).