메뉴 건너뛰기




Volumn 798, Issue 1-2, 1998, Pages 287-293

The effects of S- and R-flurbiprofen on the inflammation-evoked intraspinal release of immunoreactive substance P - A study with antibody microprobes

Author keywords

Immunoreactive substance P; Inflammation; Intraspinal release; Non steroidal anti inflammatory drug; R flurbiprofen; S flurbiprofen

Indexed keywords

FLURBIPROFEN; SUBSTANCE P;

EID: 0032490602     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00429-6     Document Type: Article
Times cited : (9)

References (46)
  • 3
    • 0023659393 scopus 로고
    • In vivo release of substance P in cat dorsal horn studied with microdialysis
    • Brodin E., Linderoth B., Gazelius B., Ungerstedt U. In vivo release of substance P in cat dorsal horn studied with microdialysis. Neurosci. Lett. 76:1987;357-362.
    • (1987) Neurosci. Lett. , vol.76 , pp. 357-362
    • Brodin, E.1    Linderoth, B.2    Gazelius, B.3    Ungerstedt, U.4
  • 5
    • 0026470747 scopus 로고
    • Pure enantiomers of 2-arylpropionic acids: Tools in pain research and improved drugs in rheumatology
    • Brune K., Geisslinger G., Menzel-Soglowek S. Pure enantiomers of 2-arylpropionic acids: tools in pain research and improved drugs in rheumatology. J. Clin. Pharmacol. 32:1992;944-952.
    • (1992) J. Clin. Pharmacol. , vol.32 , pp. 944-952
    • Brune, K.1    Geisslinger, G.2    Menzel-Soglowek, S.3
  • 6
    • 0023938734 scopus 로고
    • Depression by morphine and the non-opioid analgesic agents, metamizol (dipyrone), lysine acetylsalicylate, and paracetamol, of activity in rat thalamus neurones evoked by electrical stimulation of nociceptive afferents
    • Carlsson K.-H., Monzel W., Jurna I. Depression by morphine and the non-opioid analgesic agents, metamizol (dipyrone), lysine acetylsalicylate, and paracetamol, of activity in rat thalamus neurones evoked by electrical stimulation of nociceptive afferents. Pain. 32:1988;313-326.
    • (1988) Pain , vol.32 , pp. 313-326
    • Carlsson, K.-H.1    Monzel, W.2    Jurna, I.3
  • 8
    • 0023950602 scopus 로고
    • Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat
    • Duggan A.W., Hendry I.A., Green J.L., Morton C.R., Zhao Z.Q. Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat. Brain Res. 451:1988;261-273.
    • (1988) Brain Res. , vol.451 , pp. 261-273
    • Duggan, A.W.1    Hendry, I.A.2    Green, J.L.3    Morton, C.R.4    Zhao, Z.Q.5
  • 9
    • 0026518784 scopus 로고
    • Effect of peptidase inhibition on the pattern of intraspinally released immunoreactive substance P detected with antibody microprobes
    • Duggan A.W., Schaible H.-G., Hope P.J., Lang C.W. Effect of peptidase inhibition on the pattern of intraspinally released immunoreactive substance P detected with antibody microprobes. Brain Res. 579:1992;261-269.
    • (1992) Brain Res. , vol.579 , pp. 261-269
    • Duggan, A.W.1    Schaible, H.-G.2    Hope, P.J.3    Lang, C.W.4
  • 10
    • 0028968596 scopus 로고
    • Afferent volley patterns and the spinal release of immunoreactive substance P in the dorsal horn of the anesthetized spinal cat
    • Duggan A.W., Riley R.C., Mark M.A., MacMillan S.J.A., Schaible H.-G. Afferent volley patterns and the spinal release of immunoreactive substance P in the dorsal horn of the anesthetized spinal cat. Neuroscience. 65:1995;849-858.
    • (1995) Neuroscience , vol.65 , pp. 849-858
    • Duggan, A.W.1    Riley, R.C.2    Mark, M.A.3    MacMillan, S.J.A.4    Schaible, H.-G.5
  • 11
    • 0015505169 scopus 로고
    • Prostaglandins, aspirin-like drugs and analgesia
    • Ferreira S.H. Prostaglandins, aspirin-like drugs and analgesia. Nature. 240:1972;200-203.
    • (1972) Nature , vol.240 , pp. 200-203
    • Ferreira, S.H.1
  • 12
    • 0029823291 scopus 로고    scopus 로고
    • 2 causes sensitization of the primary afferent neuron via the spinal release of glutamate
    • 2 causes sensitization of the primary afferent neuron via the spinal release of glutamate. Inflamm. Res. 45:1996;499-502.
    • (1996) Inflamm. Res. , vol.45 , pp. 499-502
    • Ferreira, S.H.1    Lorenzetti, B.B.2
  • 13
    • 0030055160 scopus 로고    scopus 로고
    • New insights into the site and mode of antinociceptive action of flurbiprofen enantiomers
    • Geisslinger G., Schaible H.-G. New insights into the site and mode of antinociceptive action of flurbiprofen enantiomers. J. Clin. Pharmacol. 36:1996;513-520.
    • (1996) J. Clin. Pharmacol. , vol.36 , pp. 513-520
    • Geisslinger, G.1    Schaible, H.-G.2
  • 14
    • 0028300256 scopus 로고
    • Antinociceptive actions of R(-)-flurbiprofen- a non-cyclooxygenase inhibiting 2-arylpropionic acid - In rats
    • Geisslinger G., Ferreira S.H., Menzel S., Schlott D., Brune K. Antinociceptive actions of R(-)-flurbiprofen- a non-cyclooxygenase inhibiting 2-arylpropionic acid - in rats. Life Sci. 54:1994;PL173-177.
    • (1994) Life Sci. , vol.54 , pp. 173-177
    • Geisslinger, G.1    Ferreira, S.H.2    Menzel, S.3    Schlott, D.4    Brune, K.5
  • 15
    • 0026700730 scopus 로고
    • Intracerebroventricular microinjections of non-steroidal anti-inflammatory drugs abolish reperfusion hyperalgesia in the rat's tail
    • Gelgor L., Cartmell S., Mitchell D. Intracerebroventricular microinjections of non-steroidal anti-inflammatory drugs abolish reperfusion hyperalgesia in the rat's tail. Pain. 50:1992;323-329.
    • (1992) Pain , vol.50 , pp. 323-329
    • Gelgor, L.1    Cartmell, S.2    Mitchell, D.3
  • 16
    • 0023280702 scopus 로고
    • Release of substance P from the cat spinal cord
    • Go V.L.W., Yaksh T.L. Release of substance P from the cat spinal cord. J. Physiol. 391:1987;141-167.
    • (1987) J. Physiol. , vol.391 , pp. 141-167
    • Go, V.L.W.1    Yaksh, T.L.2
  • 17
    • 0022410242 scopus 로고
    • The effect of lysine acetylsalicylate on joint capsule mechanoreceptors in rats with polyinflammation
    • Guilbaud G., Iggo A. The effect of lysine acetylsalicylate on joint capsule mechanoreceptors in rats with polyinflammation. Exp. Brain Res. 61:1985;164-168.
    • (1985) Exp. Brain Res. , vol.61 , pp. 164-168
    • Guilbaud, G.1    Iggo, A.2
  • 18
    • 0022450493 scopus 로고
    • Effects of acetylsalicylic acid and indomethacin on single groups III and IV sensory units from acutely inflamed joints
    • Heppelmann B., Pfeffer A., Schaible H.-G., Schmidt R.F. Effects of acetylsalicylic acid and indomethacin on single groups III and IV sensory units from acutely inflamed joints. Pain. 26:1986;337-351.
    • (1986) Pain , vol.26 , pp. 337-351
    • Heppelmann, B.1    Pfeffer, A.2    Schaible, H.-G.3    Schmidt, R.F.4
  • 19
    • 0017181611 scopus 로고
    • Effects of substance P on functionally identified units in cat spinal cord
    • Henry J.L. Effects of substance P on functionally identified units in cat spinal cord. Brain Res. 114:1976;439-451.
    • (1976) Brain Res. , vol.114 , pp. 439-451
    • Henry, J.L.1
  • 20
    • 0028021668 scopus 로고
    • Prostacyclin enhances the evoked release of substance P and calcitonin gene-related peptide from rat sensory neurons
    • Hintgen C.M., Vasko M.R. Prostacyclin enhances the evoked release of substance P and calcitonin gene-related peptide from rat sensory neurons. Brain Res. 655:1994;51-60.
    • (1994) Brain Res. , vol.655 , pp. 51-60
    • Hintgen, C.M.1    Vasko, M.R.2
  • 21
    • 0025359789 scopus 로고
    • Central effects of the non-steroid anti-inflammatory agents, indomethacin, ibuprofen and diclofenac, determined in C-fibre-evoked activity in single neurones of the rat thalamus
    • Jurna I., Brune K. Central effects of the non-steroid anti-inflammatory agents, indomethacin, ibuprofen and diclofenac, determined in C-fibre-evoked activity in single neurones of the rat thalamus. Pain. 41:1992;71-80.
    • (1992) Pain , vol.41 , pp. 71-80
    • Jurna, I.1    Brune, K.2
  • 22
    • 0026520456 scopus 로고
    • Intrathecal injection of acetylsalicylic acid, salicylic acid, and indomethacin depresses C fibre-evoked activity in the rat thalamus and spinal cord
    • Jurna I., Spohrer B., Bock R. Intrathecal injection of acetylsalicylic acid, salicylic acid, and indomethacin depresses C fibre-evoked activity in the rat thalamus and spinal cord. Pain. 49:1992;249-256.
    • (1992) Pain , vol.49 , pp. 249-256
    • Jurna, I.1    Spohrer, B.2    Bock, R.3
  • 23
    • 0024337784 scopus 로고
    • Stimulus specificity of peripherally evoked substance P release from the rabbit dorsal horn in situ
    • Kuraishi Y., Hirota N., Sato Y., Hanshima N., Tagaki H., Satoh M. Stimulus specificity of peripherally evoked substance P release from the rabbit dorsal horn in situ. Neuroscience. 30:1989;241-250.
    • (1989) Neuroscience , vol.30 , pp. 241-250
    • Kuraishi, Y.1    Hirota, N.2    Sato, Y.3    Hanshima, N.4    Tagaki, H.5    Satoh, M.6
  • 24
    • 0022347682 scopus 로고
    • Calcitonin gene-related peptide is a potent inhibitor of substance P degradation
    • LeGreves P., Nyberg F., Terenius L., Hökfelt T. Calcitonin gene-related peptide is a potent inhibitor of substance P degradation. Eur. J. Pharmacol. 115:1985;309-311.
    • (1985) Eur. J. Pharmacol. , vol.115 , pp. 309-311
    • Legreves, P.1    Nyberg, F.2    Terenius, L.3    Hökfelt, T.4
  • 25
    • 0026795636 scopus 로고
    • Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition
    • Malmberg A.B., Yaksh T.L. Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science. 257:1992;1276-1279.
    • (1992) Science , vol.257 , pp. 1276-1279
    • Malmberg, A.B.1    Yaksh, T.L.2
  • 26
    • 0028297022 scopus 로고
    • Antinociception produced by spinal delivery of the S- and R-enantiomers of flurbiprofen in the formalin test
    • Malmberg A.B., Yaksh T.L. Antinociception produced by spinal delivery of the S- and R-enantiomers of flurbiprofen in the formalin test. Eur. J. Pharmacol. 256:1994;205-209.
    • (1994) Eur. J. Pharmacol. , vol.256 , pp. 205-209
    • Malmberg, A.B.1    Yaksh, T.L.2
  • 29
    • 0028018895 scopus 로고
    • Non-steroidal anti-inflammatory drugs and spinal nociceptive processing
    • McCormack K. Non-steroidal anti-inflammatory drugs and spinal nociceptive processing. Pain. 59:1994;9-43.
    • (1994) Pain , vol.59 , pp. 9-43
    • McCorMacK, K.1
  • 30
    • 0025801260 scopus 로고
    • Dissociation between the antinociceptive and anti-inflammatory effects of nonsteroidal anti-inflammatory drugs. A survey of their analgesic efficacy
    • McCormack K., Brune K. Dissociation between the antinociceptive and anti-inflammatory effects of nonsteroidal anti-inflammatory drugs. A survey of their analgesic efficacy. Drugs. 41:1991;533-547.
    • (1991) Drugs , vol.41 , pp. 533-547
    • McCorMacK, K.1    Brune, K.2
  • 31
  • 32
    • 0027973470 scopus 로고
    • The involvement of substance P and neurokinin-1 receptors in the responses of rat dorsal horn neurons to noxious but not to innocuous mechanical stimuli applied to the knee joint
    • Neugebauer V., Schaible H.-G., Weiretter F., Freudenberger U. The involvement of substance P and neurokinin-1 receptors in the responses of rat dorsal horn neurons to noxious but not to innocuous mechanical stimuli applied to the knee joint. Brain Res. 666:1994;207-215.
    • (1994) Brain Res. , vol.666 , pp. 207-215
    • Neugebauer, V.1    Schaible, H.-G.2    Weiretter, F.3    Freudenberger, U.4
  • 33
    • 0029612268 scopus 로고
    • Antinociceptive effects of R(-)- and S(+)-flurbiprofen on rat spinal dorsal horn neurons rendered hyperexcitable by an acute knee joint inflammation
    • Neugebauer V., Geisslinger G., Rümenapp P., Weiretter F., Szelenyi I., Brune K., Schaible H.-G. Antinociceptive effects of R(-)- and S(+)-flurbiprofen on rat spinal dorsal horn neurons rendered hyperexcitable by an acute knee joint inflammation. J. Pharmacol. Exp. Ther. 275:1995;618-628.
    • (1995) J. Pharmacol. Exp. Ther. , vol.275 , pp. 618-628
    • Neugebauer, V.1    Geisslinger, G.2    Rümenapp, P.3    Weiretter, F.4    Szelenyi, I.5    Brune, K.6    Schaible, H.-G.7
  • 34
    • 0028959583 scopus 로고
    • The involvement of substance P and neurokinin-1 receptors in the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint
    • Neugebauer V., Weiretter F., Schaible H.-G. The involvement of substance P and neurokinin-1 receptors in the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint. J. Neurophysiol. 73:1995;1574-1583.
    • (1995) J. Neurophysiol. , vol.73 , pp. 1574-1583
    • Neugebauer, V.1    Weiretter, F.2    Schaible, H.-G.3
  • 35
    • 0030061488 scopus 로고    scopus 로고
    • The role of spinal neurokinin-2 receptors in the processing of nociceptive information from the joint and in the generation and maintenance of inflammation-evoked hyperexcitability of dorsal horn neurons in the rat
    • Neugebauer V., Rümenapp P., Schaible H.-G. The role of spinal neurokinin-2 receptors in the processing of nociceptive information from the joint and in the generation and maintenance of inflammation-evoked hyperexcitability of dorsal horn neurons in the rat. Eur. J. Neurosci. 8:1996;249-260.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 249-260
    • Neugebauer, V.1    Rümenapp, P.2    Schaible, H.-G.3
  • 36
    • 0029879057 scopus 로고    scopus 로고
    • Calcitonin gene-related peptide is involved in the generation and maintenance of hyperexcitability of dorsal horn neurons observed during development of acute inflammation in rat's knee joint
    • Neugebauer V., Rümenapp P., Schaible H.-G. Calcitonin gene-related peptide is involved in the generation and maintenance of hyperexcitability of dorsal horn neurons observed during development of acute inflammation in rat's knee joint. Neuroscience. 71:1996;1095-1109.
    • (1996) Neuroscience , vol.71 , pp. 1095-1109
    • Neugebauer, V.1    Rümenapp, P.2    Schaible, H.-G.3
  • 38
    • 0026340721 scopus 로고
    • Effects of pure enantiomers of flurbiprofen in comparison to racemic flurbiprofen on eicosanoid release from various rat organs in vitro
    • Peskar B.M., Kluge S., Peskar B.A., Menzel-Soglowek S., Brune K. Effects of pure enantiomers of flurbiprofen in comparison to racemic flurbiprofen on eicosanoid release from various rat organs in vitro. Prostaglandins. 42:1991;515-531.
    • (1991) Prostaglandins , vol.42 , pp. 515-531
    • Peskar, B.M.1    Kluge, S.2    Peskar, B.A.3    Menzel-Soglowek, S.4    Brune, K.5
  • 39
    • 0027433726 scopus 로고
    • Afferent and spinal mechanisms of joint pain
    • Schaible H.-G., Grubb B.D. Afferent and spinal mechanisms of joint pain. Pain. 55:1993;5-54.
    • (1993) Pain , vol.55 , pp. 5-54
    • Schaible, H.-G.1    Grubb, B.D.2
  • 40
    • 0025104302 scopus 로고
    • Release of immunoreactive substance P in the cat spinal cord during development of acute arthritis in cat's knee: A study with antibody bearing microprobes
    • Schaible H.-G., Jarrott B., Hope P.J., Duggan A.W. Release of immunoreactive substance P in the cat spinal cord during development of acute arthritis in cat's knee: a study with antibody bearing microprobes. Brain Res. 529:1990;214-223.
    • (1990) Brain Res. , vol.529 , pp. 214-223
    • Schaible, H.-G.1    Jarrott, B.2    Hope, P.J.3    Duggan, A.W.4
  • 42
    • 0029128164 scopus 로고
    • Anti-nociception induced by systemic or PAG-microinjected lysine-acetylsalicylate in rats. Effects on tail-flick related activity of medullary off and on cells
    • Tortorici V., Vanegas H. Anti-nociception induced by systemic or PAG-microinjected lysine-acetylsalicylate in rats. Effects on tail-flick related activity of medullary off and on cells. Eur. J. Neurosci. 7:1995;1857-1865.
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 1857-1865
    • Tortorici, V.1    Vanegas, H.2
  • 43
    • 0027933184 scopus 로고
    • Modulation of spinal excitability: Cooperation between neurokinin and excitatory amino acid transmitters
    • Urban L., Thompson S.W.N., Dray A. Modulation of spinal excitability: cooperation between neurokinin and excitatory amino acid transmitters. TINS. 17:1994;432-438.
    • (1994) TINS , vol.17 , pp. 432-438
    • Urban, L.1    Thompson, S.W.N.2    Dray, A.3
  • 44
    • 0015237292 scopus 로고
    • Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
    • Vane J.R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature. 231:1971;232-235.
    • (1971) Nature , vol.231 , pp. 232-235
    • Vane, J.R.1
  • 45
    • 0028169759 scopus 로고
    • 2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture
    • 2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture. J. Neurosci. 14:1994;4687-4997.
    • (1994) J. Neurosci. , vol.14 , pp. 4687-4997
    • Vasko, M.R.1    Campbell, W.B.2    Waite, K.J.3
  • 46
    • 0018424359 scopus 로고
    • Effects of substance P on neurons in the dorsal horn of the spinal cord of the cat
    • Zieglgänsberger W., Tulloch I.F. Effects of substance P on neurons in the dorsal horn of the spinal cord of the cat. Brain Res. 166:1979;273-282.
    • (1979) Brain Res. , vol.166 , pp. 273-282
    • Zieglgänsberger, W.1    Tulloch, I.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.