Ascorbic acid stimulates DOPA synthesis and tyrosine hydroxylase gene expression in the human neuroblastoma cell line SK-N-SH

Neuroscience Letters

Volumn 244, Issue 1, 1998, Pages 33-36

  Seitz, Gabriele ^a   Gebhardt, Sabine ^a   Beck, James F ^a   Böhm, Waltraud ^a   Lode, Holger N ^a   Niethammer, Dietrich ^a   Bruchelt, Gernot ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

3,4 Dihydroxyphenylalanine; Ascorbic acid; Catecholamine synthesis; Neuroblastoma; Parkinson's disease; Tyrosine hydroxylase

Indexed keywords

ASCORBIC ACID; COMPLEMENTARY DNA; DOPA; DOPAMINE; MESSENGER RNA; TYROSINE 3 MONOOXYGENASE;

ARTICLE; CANCER CELL CULTURE; CATECHOLAMINE SYNTHESIS; DRUG MECHANISM; GENE EXPRESSION; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PARKINSON DISEASE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ASCORBIC ACID; CATECHOLAMINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIHYDROXYPHENYLALANINE; DOPAMINE BETA-HYDROXYLASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEUROBLASTOMA; POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TUMOR CELLS, CULTURED; TYROSINE 3-MONOOXYGENASE;

EID: 0032489542     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00129-3     Document Type: Article

References (15)

1. Baader S.L., Bruchelt G., Trautner M.C., Boschert H., Niethammer D. Uptake and cytotoxicity of ascorbic acid and dehydroascorbic acid in neuroblastoma (SK-N-SH) and neuroectodermal (SK-N-LO) cells. Anticancer Res. 14:1994;221-227.
2. Beck J., Handgretinger R., Dopfer R., Klingebiel T., Niethammer D., Gekeler V. Expression of mdr 1, mrp, topoisomerase II alpha/beta and cyclin A in primary or relapsed states of acute lymphoblastic leukemias. Br. J. Hematol. 89:1995;356-363.
3. 125I iodobenzylguanidine in the human neuroblastoma cell line SK-N-SH. Cancer Res. 45:1985;6366-6370.
4. Ciccarone V., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A. Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages. Cancer Res. 49:1989;219-225.
5. Davies, M.B., Austin, J. and Partridge, D.A., Vitamin C: Its Chemistry and Biochemistry, Royal Society of Chemistry Paperbacks, Cambridge, 1991.
6. Doba T., Burton G.W., Ingold K.U. Antioxidant and co-antioxidant effect of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes. Biochim. Biophys. Acta. 835:1985;298-303.
7. Fahn S., Cohen G. The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Ann. Neurol. 32:1992;804-812.
8. Fahn S. An open trial of high-dosage antioxidants in early Parkinson's disease. Am. J. Clin. Nutr. 53:1991;380S-382S.
9. Hofmann H., Schmidt H.H.H.W. Thiol dependence of nitric oxide synthase. Biochemistry. 34:1995;13443-13452.
10. Huang W., Yang Z., Lee D., Copolov D.L., Lim A.T. Ascorbic acid enhances forskolin-induced cyclic AMP production and pro-ANF mRNA expression of hypothalamic neurons in culture. Endocrinology. 132:1993;2271-2273.
11. Levine M., Morita K., Heldman E., Pollard H.B. Ascorbic acid regulation of norepinephrine biosynthesis in isolated chromaffin granules from bovine adrenal medulla. J. Biol. Chem. 260:1985;15598-15603.
12. Lewis E.J., Harrington C.A., Chikarashi D.M. Transcriptional regulation of the tyrosine hydroxylase gene by glucocorticoid and cyclic AMP. Proc. Natl. Acad. Sci. USA. 84:1987;3550-3554.
13. Lode H.N., Bruchelt G., Seitz G., Gebhardt S., Gekeler V., Niethammer D., Beck J. Reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of monoamine transporters in neuroblastoma cell lines: correlations to meta-iodobenzylguanidine (mIBG) uptake and tyrosine hydroxylase gene expression. Eur. J. Cancer. 31A:1995;586-590.
14. The Parkinson Study Group, Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease, New Engl. J. Med., 328 (1993) 176-183.
15. Zigmond R.E., Schwarzschild M.A., Rittenhouse A.R. Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation. Annu. Rev. Neurosci. 12:1989;415-461.