On the mechanism of microbial cell disruption in high-pressure homogenisation

Chemical Engineering Science

Volumn 53, Issue 5, 1998, Pages 891-898

  Kleinig, Andrew R ^b   Middelberg, Anton P J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NONE

Author keywords

Cavitation; Cell disruption; Homogeniser; Mechanism; Viscous shear; Yeast

Indexed keywords

REYNOLDS NUMBER; STRAIN RATE; SURFACE TENSION; YEAST;

HIGH PRESSURE HOMOGENIZATION; MICROBIAL CELL DISRUPTION; WEBER NUMBER;

CELLS;

EID: 0032489046     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2509(97)00414-4     Document Type: Article

References (19)

1. Barthes-Biesel, D. and Rallison, J. M. (1981) The time-dependent deformation of a sphere freely suspended in a linear shear flow. J. Fluid Mech. 113, 251-267.
2. Bird, R. B., Stewart, W. E. and Lightfoot, E. N. (1960) Transport Phenomena, pp. 58-59. Wiley, New York, U.S.A.
3. Chang, K. S. and Olbricht, W. L. (1993) Experimental studies of the deformation of a synthetic sphere in extensional flow. J. Fluid Mech. 250, 587-608.
4. Hammitt, F. G. (1996) Cavitation. In: Handbook of Fluid Dynamics and Fluid Machinery. Vol. 3: Applications of Fluid Dynamics, eds J. A. Schetz and A. E. Fuhs, pp. 1769-1788. Wiley, New York, U.S.A.
5. Harrison, S. T. L. (1990) Ph.D. dissertation, University of Cambridge, U.K.
6. Kleinig, A. R. and Middelberg, A. P. J. (1996) Correlation of cell disruption with homogenizer valve pressure gradient determined by computational fluid dynamics. Chem. Engng Sci. 51, 5103-5110.
7. Kleinig, A. R. (1997). Ph.D. dissertation, The University of Adelaide, Australia.
8. Leyrat-Maurin, A. and Barthes-Biesel, D. (1994) Motion of a deformable sphere through a hyperbolic constriction. J. Fluid Mech. 279, 135-163.
9. Li, X. Z., Barthes-Biesel, D. and Helmy, A. (1988) Large deformations and burst of a sphere freely suspended in an elongational flow. J. Fluid Mech. 187, 179-196.
10. Magnaudet, J., Rivero, M. and Fabre, J. (1995) Accelerated flows past a rigid sphere or a spherical bubble. Part 1. Steady straining flow. J. Fluid Mech. 284, 97-135.
11. Middelberg, A. P. J. (1995) Process-scale disruption of microorganisms. Biotech. Adv. 13, 491-551.
12. Pozrikidis, C. (1990) The axisymmetric deformation of a red blood cell in uniaxial straining Stokes flow. J. Fluid Mech. 216, 231-254.
13. Roberts, A. D., Zhang, Z., Young, T. W. and Thomas, C. R. (1994) Direct determination of the strength of brewing yeast cells using micromanipulation. Inst. Chem. Engng Res. Event, London, pp. 73-75.
14. Ryskin, G. and Leal, L. G. (1984) Numerical solution of free-boundary problems in fluid mechanics. Part 3. Bubble deformation in an axisymmetric straining flow. J. Fluid Mech. 148, 37-43.
15. Save, S. S., Pandit, A. B. and Joshi, J. B. (1997) Use of hydrodynamic cavitation for large scale microbial cell disruption. Trans. Inst. Chem. Engng Part C: Food and Bioprod. Proc. 75, 41-49.
16. Shamlou, P. A., Siddiqi, S. F. and Titchener-Hooker, N. J. (1995) A Physical model of high-pressure disruption of baker's yeast cells. Chem. Engng Sci. 50, 1383-1391.
17. Timoshenko, S. and Woinowsky-Krieger, S. (1959) Deformation of shells without bending. In: Theory of Plates and Shells, 2nd ed., pp. 433-435. McGraw-Hill Book Company, New York, U.S.A.
18. Ward, I. M. and Hadley, D. W. (1993) An Introduction to the Mechanical Properties of Solid Polymers. Wiley, Chichester, U.K.
19. Zhou, H. and Pozrikidis, C. (1995) Deformation of liquid spheres with incompressible interfaces in simple shear flow. J. Fluid Mech. 283, 175-200.