5-aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 1, 1998, Pages 71-74

  Auberson, Yves P ^a   Acklin, Pierre ^a   Allgeier, Hans ^a   Biollaz, Michel ^a   Bischoff, Serge ^a   Ofner, Silvio ^a   Veenstra, Siem J ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINOMETHYLQUINOXALINE 2,3 DIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; QUINOXALINES; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032488644     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10187-1     Document Type: Article

References (17)

1. 1. a) Choi, D.W.; Rothman, S.M. Annual Rev. Neurol. 1990 13-171;
2. b) Bradford, H.F. Progress in Neurobiology 1995 47 477.
3. 2. a) Keana, J.F.W.; Kher, S.M.; Cai, S.X.; Dinsmore, C.M.; Glenn, A.G.; Guastella, J.; Huang, J.-C.; Ilyin, V.; Lü, Y.; Mouser, P.L; Woodward, R.M.; Weber, E. J. Med. Chem. 1995 38 4367;
4. b) Nagata, R.; Tanno, N.; Kodo, T.; Ae, N.; Yamaguchi, H.; Nishimura, T.; Antoku, F.; Tatsuno, T.; Kato, T.; Tanaka, Y.; Nakamura, M. J. Med. Chem. 1994 37 3956;
5. c) Epperson, J.R.; Hewawasam, P.; Meanwell, N.A.; Boissard, C.G.; Gribkoff, V.K.; Post-Munson, D. Bioorg. and Med. Chem. Lett. 1993 3 2801.
6. 3. Leeson, P.D.; Iversen, L.L. J. Med. Chem. 1994 37 4053.
7. 4. McCulloch, J.; Bullock, R.; Teasdale, G.M. In Excitatory Amino Acid Antagonists; Meldrum, B., Ed.; Blackwell Scientific Publications: Oxford 1991 287.
8. 5. a) Mignani, S., Aloup, J.-C., Barreau, M.; Birraux, G.; Blanchard, J.-C.; Böhme, A.; Boireau, A; Damour, D.; Doble, A.; Jimonet, P.; Malgouris, C.; Mary, V.; Randle, J.C.R.; Rataud, J.; Stutzman, J.-M. Drugs of the Future 1995 20 1133.
9. b) Kulagowski, J.J.; Baker, R.; Curtis, N.R.; Leeson, P.D.; Mawer, I.M.; Moseley, A.M.; Ridgill, M.P.; Rowley, M.; Stansfield, I.; Foster, A.C.; Grimwood, S.; Hill, R.G.; Kemp, J.A.; Marshall, G.R.; Syawell, K.L.; Trickelbank, M.D. J. Med. Chem. 1994 37 1402, and ref. cited therein.
10. 6. a) Woodward, R.M.; Huettner, J.E.; Guastella, J.; Keana, J.F.W.; Weber, E. Mol. Pharmacol. 1995 47 568.
11. b) Warner, D.S.; Martin, H.; Ludwig , P.; McAllister, A.; Keana, J.F.W.; Weber, E. J. Cereb. Blood Flow Metab. 1995 15 188.
12. 7. Di Fabio, R.; Capelli, A.; Conti, N.; Cugola, A.; Donati, D.; Feriani, A.; Gastaldi, P.; Gaviraghi, G.; Hewkin, C.T.; Micheli, F.; Missio, A.; Mugnaini, M.; Pecunioso, A.; Quaglia, A.M.; Ratti, E.; Rossi, L.; Tedesco, G.; Trist, D.G.; Reggiani, A. J. Med. Chem. 1997 40 841.
13. 8. Kulagowski, J.J.; Leeson, P.D. Exp. Opin. Ther. Patents 1995 5 1061.
14. 9. Auberson, Y.P.; Bischoff, S.; Moretti, R.; Schmutz, M.; Veenstra, S.J. Bioorg. and Med. Chem. Letters, proceeding article.
15. 10. a) St. Clair, R.L.; Thibault, T.D. US Patent # 3992378 1976 (CA 86:89890m).
16. 11. a) Honoré, T.; Lauridsen, J.; Krogsgaard-Larsen, P. J. Neurochem. 1982 38 173;
17. b) Baron, B.M., Siegel, B.W., Harrison, B.L., Gross, R.S., Hawes, C. and Towers, P. J. Pharmacol. Exp. Ther. 1996 279 62-68.