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0010697489
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note
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7 cells. From 3 days after the second cell injection, drug was administered orally once a day for 8 weeks. To assess the renal disease, proteinuria were measured after the last drug administration. The concentration of serum albumin in the urine was determined by the single radial immunodiffusion method using rabbit anti-mouse serum albumin antiserum. Ten mice were used per group. The activity of the compound was expressed as a % inhibition of proteinuria.
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26
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0010742326
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note
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24. The test compound was given orally once a day for 5 days to female ddY mice aged 6 weeks. The number of RBC were counted 5 days after the final dosing with the test compound, in which mice were bled from the orbital plexus and the RBC were counted with an automatic blood analyzer. The incidence of RBC decrease was expressed by the number of mice with a decreased number of RBC (<80% of the control animals) vs. the number of tested mice.
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27
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0010742079
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note
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25. Data for platelets are not shown.
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28
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0010656486
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note
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26. Unpublished results of the Toxicology Research Laboratories.
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29
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0025344323
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27. Mizutani, H.; Furubayashi, T.; Kuriu, A.; Take, H.; Tomiyama, Y.; Yoshida, H.; Nakamura, Y.; Inaba, M.; Kurata, Y.; Yonezawa, T.; Tarui, S.; Ikehara, S. Blood 1990, 75, 1809.
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Nakamura, Y.7
Inaba, M.8
Kurata, Y.9
Yonezawa, T.10
Tarui, S.11
Ikehara, S.12
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30
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0010740131
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28. Manda, T.; Nishigaki, F.; Tsujimoto, S.; Inami, M.; Matsumoto, S.; Naoe, Y.; Kawamura, I.; Ogawa, T.; Shimomura, K. Jpn. J. Pharmacol. 1997, 73(Suppl. 1), 152.
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Kawamura, I.7
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Shimomura, K.9
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31
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0010654690
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note
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1 mice.
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32
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0010656487
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