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Volumn 8, Issue 1, 1998, Pages 75-80

Discovery of FR115092 : A novel antinephritic agent

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOTHIAZOLYL DERIVATIVE; 4 AMINOPHENYL DERIVATIVE; DAPSONE DERIVATIVE; FR 115092; UNCLASSIFIED DRUG;

EID: 0032488613     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10192-5     Document Type: Article
Times cited : (8)

References (32)
  • 15
    • 0010703268 scopus 로고
    • Organic syntheses
    • John Wiley & Sons: New York
    • 13. Ferry, C.W.; Buck, J.S.; Baltzly, R. In Organic Syntheses; John Wiley & Sons: New York, 1955; Collect. Vol. 3, pp239-241.
    • (1955) Collect. , vol.3 , pp. 239-241
    • Ferry, C.W.1    Buck, J.S.2    Baltzly, R.3
  • 25
    • 0010697489 scopus 로고    scopus 로고
    • note
    • 7 cells. From 3 days after the second cell injection, drug was administered orally once a day for 8 weeks. To assess the renal disease, proteinuria were measured after the last drug administration. The concentration of serum albumin in the urine was determined by the single radial immunodiffusion method using rabbit anti-mouse serum albumin antiserum. Ten mice were used per group. The activity of the compound was expressed as a % inhibition of proteinuria.
  • 26
    • 0010742326 scopus 로고    scopus 로고
    • note
    • 24. The test compound was given orally once a day for 5 days to female ddY mice aged 6 weeks. The number of RBC were counted 5 days after the final dosing with the test compound, in which mice were bled from the orbital plexus and the RBC were counted with an automatic blood analyzer. The incidence of RBC decrease was expressed by the number of mice with a decreased number of RBC (<80% of the control animals) vs. the number of tested mice.
  • 27
    • 0010742079 scopus 로고    scopus 로고
    • note
    • 25. Data for platelets are not shown.
  • 28
    • 0010656486 scopus 로고    scopus 로고
    • note
    • 26. Unpublished results of the Toxicology Research Laboratories.
  • 31
    • 0010654690 scopus 로고    scopus 로고
    • note
    • 1 mice.
  • 32
    • 0010656487 scopus 로고    scopus 로고
    • note
    • 1-4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.