Extracellular acidification modifies Ca2+ fluxes in rat brain synaptosomes

Biochemical and Biophysical Research Communications

Volumn 242, Issue 1, 1998, Pages 123-128

  Saadoun, Samira ^a   Lluch, Mónica ^a   Rodríguez Álvarez, José ^a   Blanco, Isaac ^a   Rodríguez, Ricardo ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Acidification; Ca2+ fluxes; External pH; Na+ Ca2+ exchanger; Phosphoinositide hydrolisis; Synaptosomes; Voltage sensitive calcium channels

Indexed keywords

AMILORIDE; CALCIUM CHANNEL; DILTIAZEM; NEOMYCIN; NIFEDIPINE; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C; PROTON; SODIUM; VERAPAMIL;

ACIDIFICATION; ANIMAL CELL; ARTICLE; BRAIN SYNAPTOSOME; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; EFFUSION; HYDROLYSIS; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SODIUM CALCIUM EXCHANGE;

ANIMALIA;

EID: 0032488532     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1997.7927     Document Type: Article

References (33)

1. Chesler M. The regulation and modulation of pH in the nervous system. Progress in Neurobiology. 34:1990;401-427.
2. Chesler M., Kaila K. Modulation of pH by neuronal activity. Trends in Neurosci. 15:1992;396-402.
3. Tombaugh G. C., Sapolsky R. M. Evolving concepts about the role of acidosis in ischemic neuropathology. J. Neurochem. 61:1993;793-803.
4. Ou-Yang Y. B., Mellergard P., Kristián T., Kristiánova V., Siesjö B. K. Influence of acid-base changes on the intracellular calcium concentration of neurons in primary culture. Exp. Brain Res. 101:1994;265-271.
5. Drapeau P., Nachshen D. A. Effects of lowering extracellular and cytosolic pH on calcium fluxes, cytosolic calcium levels and transmitter release in presynaptic nerve terminals isolated from rat brain. J. Gen. Physiol. 91:1988;305-315.
6. 2+. J. Biol. Chem. 264:1989;8723-8728.
7. +452+. J. Neurosci. Methods. 59:1995;111-120.
8. Busa W., Nuccitelli R. Metabolic regulation via intracellular pH. Am. J. Physiol. 246:1984;R409-R438.
9. +. Annu. Rev. Neurosci. 1984;257-278.
10. Meldrum B., Garthwaiter J. Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci. 11:1991;379-387.
11. Benveniste H., Drejer J., Schousboe A., Diemer N. H. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43:1984;1369-1374.
12. Lafon-Cazal M., Pietri S., Culcasi M., Bockaert J. NMDA-dependent superoxide production and neurotoxicity. Nature. 364:1993;535-537.
13. Kaku D. A., Griffard R. G., Choi D. W. Neuroprotective effects of glutamate antagonists and extracellular acidity. Science. 260:1993;1516-1518.
14. Andreeva N., Khodorov B., Stelmashook E., Sokolova S., Cragoe E. Jr., Voctorov I. 5-(N-ethyl-N-isopropyl)amiloride and mild acidosis protect cultured cerebellar granule cells againts glutamate-induced delayed neuronal death. Neuroscience. 49:1992;175 - 181.
15. Griffard R. G., Monyer H., Christine C. W., Choi D. W. Acidosis reduces NMDA receptor activation, glutamate neurotoxicity and oxygen-glucose deprivation neuronal injury in cortical cultures. Brain Res. 506:1989;339-342.
16. Nachshen D. A., Blaustein M. P. Regulation of nerve terminal calcium channel selectivity by a weak acid site. Biophysical J. 26:1979;329-334.
17. Reuter H. Diversity and function of presynaptic calcium channels in the brain. Curr. Opin. Neurobiol. 6:1996;331-337.
18. Rahamimoff H., Spanier R. Sodium-dependent calcium uptake in membrane vesicles derived from rat brain synaptosomes. FEBS Lett. 104:1979;111-114.
19. +2+. Neuron. 15:1995;1077-1084.
20. 2+. J. Gen. Physiol. 72:1978;43-66.
21. Nicholls D. G., Scott I. D. The role of mitochondria in the regulation of calcium transport in synaptosomes. Biochem. Soc. Trans. 8:1980;246-266.
22. Dodd P. R., Hardy J. A., Oakley A. E., Edwardson J. A., Perry E. K., Delaunoy J. P. A rapid method for preparing synaptosomes: Comparison with alternative procedures. Brain Res. 226:1981;107 - .
23. Lowry O. H., Rosebrogh N. J., Farr A. L., Randall R. J. Protein determination with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
24. Johnson M., Whittaker V. P. Lactate dehydrogenase as a cytoplasmatic marker in brain. Biochem. J. 88:1963;404-449.
25. 452+. Biochem. Pharmacol. 36:1987;974-976.
26. 2+2+3. Biochem. Pharmacol. 44:1992;301-308.
27. Claro E., Fain J. N., Picatoste F. Noradrenaline stimulation imbalances the phosphoinositide cycle in rat cerebral cortical slices. J. Neurochem. 60:1993;2078-2085.
28. 2+. Trends Neurosci. 18:1995;89-98.
29. 2+. Proc. Natl. Acad. Sci. USA. 83:1986;654-658.
30. Klockner U., Isenberg G. Calcium channel current of vascular smooth muscle cells: extracellular protons modulate gating and single channel conductance. J. Gen. Physiol. 103:1994;665-678.
31. Sánchez-Armass S., Martínez-Zaguillán R., Martínez G. M., Gillies R. Regulation of pH in rat brain synaptosomes. I. Role of sodium, bicarbonate, and potassium. J. Neurophysiol. 71:1994;2236-2248.
32. Ou-Yang Y., Kristián T., Mellergard P., Siesjö B. K. The influence of pH on glutamate- and depolarization-induced increases of intracellular calcium concentration in cortical neurons in primary culture. Brain Res. 646:1994;65-72.
33. Choi D. W., Rothman S. M. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu. Rev. Neurosci. 13:1990;171-182.