Phosphorylation of the M2 protein of influenza A virus is not essential for virus viability

Virology

Volumn 252, Issue 1, 1998, Pages 54-64

  Thomas, Joanne M ^a   Stevens, Mark P ^a   Percy, Neil ^a   Barclay, Wendy S ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN;

ACIDIFICATION; ARTICLE; CELL VIABILITY; GENE MUTATION; GENETIC ANALYSIS; INFLUENZA VIRUS A; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SEQUENCE HOMOLOGY; VIRUS ENVELOPE; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS VIRULENCE;

INFLUENZA A VIRUS; INFLUENZA VIRUS; RNA VIRUSES;

EID: 0032488264     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1998.9384     Document Type: Article

References (51)

1. Bebbington C. R. Expression of antibody genes in nonlymphoid mammalian cells. Methods Enzymol. 2:1991;136-145.
2. Betakova T., Nermut M. V., Hay A. J. The NB protein is an integral component of the membrane of influenza B virus. J. Gen. Virol. 77:1996;2689-2694.
3. Bilsel P., Castrucci M. R., Kawaoka Y. Mutations in the cytoplasmic tail of influenza A virus neuraminidase affect incorporation into virions. J. Virol. 67:1993;6762-6767.
4. Brassard D. L., Leser G. P., Lamb R. A. Influenza B virus NB glycoprotein is a component of the virion. Virology. 220:1996;350-360.
5. Bui M., Whittaker G., Helenius A. Effect of M1 protein and low pH on nuclear transport of influenza virus ribonucleoproteins. J. Virol. 70:1996;8391-8401.
6. Bukreyev A., Whitehead S. S., Murphy B. R., Collins P. L. Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse. J. Virol. 71:1997;8973-8982.
7. Casanova J. E., Breitfeld P. P., Ross S. A., Mostov K. E. Phosphorylation of the polymeric immunoglobulin receptor is required for its efficient transcytosis. Science. 248:1990;742-745.
8. Castrucci M. R., Hughes M., Calzoletti L., Donatelli I., Wells K., Takada A., Kawaoka Y. The cysteine residues of the M2 protein are not required for influenza A virus replication. Virology. 238:1997;128-134.
9. Castrucci M. R., Kawaoka Y. Reverse genetics system for generation of an influenza A virus mutant containing a deletion of the carboxyl-terminal residue of M2 protein. J. Virol. 69:1995;2725-2728.
10. Duff K. C., Gilchrist P. J., Saxena A. M., Bradshaw J. P. Neutron-diffraction reveals the site of amantadine blockade in the influenza A M2 ion-channel. Virology. 202:1994;287-293.
11. Enami M., Enami K. Influenza virus hemagglutinin and neuraminidase glycoproteins stimulate the membrane association of the matrix protein. J. Virol. 70:1996;6653-6657.
12. Enami M., Luytjes W., Krystal M., Palese P. Introduction of site-specific mutations into the genome of influenza virus. Proc. Natl. Acad. Sci. USA. 87:1990;3802-3805.
13. Enami M., Palese P. High-efficiency formation of influenza virus transfectants. J. Virol. 65:1991;2711-2713.
14. Garcia-Sastre A., Palese P. The cytoplasmic tail of the neuraminidase protein of influenza A virus does not play an important role in the packaging of this protein into viral envelopes. Virus Res. 37:1995;37-47.
15. Hay A. J. The action of adamantamines against influenza A viruses: inhibition of the M2 ion channel protein. Semin. Virol. 3:1992;21-30.
16. Holsinger L. J., Shaughnessy M. A., Micko A., Pinto L. H., Lamb R. A. Analysis of the posttranslational modifications of the influenza virus M2 protein. J. Virol. 69:1995;1219-1225.
17. Hongo S., Sugawara K., Murai Y., Kitame F., Nakamura K. Characterization of a second protein (CM2) encoded by RNA segment 6 of influenza C virus. J. Virol. 71:1997;2786-2792.
18. Hughey P. G., Compans R. W., Zebedee S. L., Lamb R. A. Expression of the influenza A virus M2 protein is restricted to apical surfaces of polarized epithelial-cells. J. Virol. 66:1992;5542-5552.
19. Hughey P. G., Roberts P. C., Holsinger L. J., Zebedee S. L., Lamb R. A., Compans R. W. Effects of antibody to the influenza A virus M2 protein on M2 surface expression and virus assembly. Virology. 212:1995;411-421.
20. Jin H., Leser G. P., Zhang J., Lamb R. A. Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape. EMBO J. 16:1997;1236-1247.
21. Jones B. G., Thomas L., Molloy S. S., Thulin C. D., Fry M. D., Walsh K. A., Thomas G. Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase-II site in its cytoplasmic tail. EMBO J. 14:1995;5869-5883.
22. Kato A., Kiyotani K., Sakai Y., Yoshida T., Nagai Y. The paramyxovirus, Sendai virus, V protein encodes a luxury function required for viral pathogenesis. EMBO J. 16:1997;578-587.
23. Kretzschmar E., Bui M., Rose J. K. Membrane association of influenza virus matrix protein does not require specific hydrophobic domains or the viral glycoproteins. Virology. 220:1996;37-45.
24. Lamb R. A., Lai C.-J., Choppin P. W. Sequences of mRNAs derived from genome RNA segment & of influenza A virus: colinear and interrupted mRNAs code for overlapping proteins. Proc. Natl. Acad. Sci. USA. 78:1981;4170-4174.
25. Lamb R. A., Zebedee S. L., Richardson C. D. Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell. 40:1985;627-633.
26. Liu N., Brown D. T. Phosphorylation and dephosphorylation events play critical roles in Sindbis virus maturation. Virology. 196:1993;703-711.
27. Martin K., Helenius A. Nuclear transport of influenza virus ribonucleoproteins: the viral matrix protein (M1) promotes export and inhibits import. Cell. 67:1991;117-130.
28. Naim H. Y., Roth M. G. Characteristics of the internalization signal in the Y543 influenza virus hemagglutinin suggest a model for recognition of internalization signals containing tyrosine. J. Biol. Chem. 269:1994;3928-3933.
29. Neumann G., Castrucci M. R., Kawaoka Y. Nuclear import and export of influenza virus nucleoprotein. J. Virol. 71:1997;9690-9700.
30. Panayotov P. P., Schlesinger R. W. Oligomeric organization and strain-specific proteolytic modification of the virion M2 protein of influenza A H1N1 viruses. Virology. 186:1992;352-355.
31. Park E. K., Castrucci M. R., Portner A., Kawaoka Y. The M2 ectodomain is important for its incorporation into influenza A virions. J. Virol. 72:1998;2449-2455.
32. Pekosz A., Lamb R. A. The CM2 protein of influenza C virus is an oligomeric integral membrane glycoprotein structurally analogous to influenza A virus M2 and influenza B virus NB proteins. Virology. 237:1997;439-451.
33. Pinto L. H., Holsinger L. J., Lamb R. A. Influenza virus M2 protein has ion channel activity. Cell. 69:1992;517-528.
34. Pugh J., Zweidler A., Summers J. Characterization of the major duck hepatitis B virus core particle protein. J. Virol. 63:1989;1371-1376.
35. Radecke F., Billeter M. A. The nonstructural C protein is not essential for multiplication of Edmonston B strain measles virus in cultured cells. Virology. 217:1996;418-421.
36. Roberts P. C., Lamb R. A., Compans R. W. The M1 and M2 proteins of influenza A virus are important determinants in filamentous particle formation. Virology. 240:1998;127-137.
37. Sakaguchi T., Kiyotani K., Kato A., Asakawa M., Fujii Y., Nagai Y., Yoshida T. Phosphorylation of the Sendai virus M protein is not essential for virus replication eitherin vitroin vivo. Virology. 235:1997;360-366.
38. Scheiffele P., Roth M. G., Simons K. Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain. EMBO J. 16:1997;5501-5508.
39. Shaw M. W., Choppin P. W. Studies on the synthesis of the influenza B virus NB glycoprotein. Virology. 139:1984;178-184.
40. Shih S. R., Krug R. M. Novel exploitation of a nuclear function by influenza virus: the cellular Sf2/Asf splicing factor controls the amount of the essential viral M2 ion-channel protein in infected cells. EMBO J. 15:1996;5415-5427.
41. Sklyanskaya E. I., Varich N. L., Amvrosieva T. V., Kaverin N. V. Virions and intracellular nucleocapsids produced during mixed heterotypic influenza infection of MDCK cells. J. Virol. 53:1985;679-683.
42. Stevens M. P., Barclay W. S. The N-terminal extension of the influenza B virus nucleoprotein is not required for nuclear accumulation or the expression and replication of a model RNA. J. Virol. 72:1998;5307-5312.
43. Ward T., Pipkin P. A., Clarkson N. A., Stone D. M., Minor P. D., Almond J. W. Decay-accelerating factor CD55 is identified as the receptor for echovirus-7 using CELICS, a rapid immune-focal cloning method. EMBO J. 13:1994;5070-5074.
44. Wertz, G. W. Perepelitsa, V. P. Ball, L. A. 1997, Attenuation of replication and virulence of a non-segmented negative strand RNA virus by rearrangement of the gene order.
45. Whittaker G., Kemler I., Helenius A. Hyperphosphorylation of mutant influenza matrix protein, M1, causes its retention in the nucleus. J. Virol. 69:1995;439-445.
46. Yamashita M., Krystal M., Palese P. Evidence that the matrix protein of influenza C virus is coded for by a spliced mRNA. J. Virol. 62:1988;3348-3355.
47. Yasuda J., Bucher D. J., Ishihama A. Growth-control of influenza A virus by M1 protein: analysis of transfectant viruses carrying the chimeric M gene. J. Virol. 68:1994;8141-8146.
48. Zebedee S. L., Lamb R. A. Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions. J. Virol. 62:1988;2762-2772.
49. Zebedee S. L., Lamb R. A. Growth restriction of influenza A virus by M2 protein antibody is genetically linked to the M1 protein. Proc. Natl. Acad. Sci. USA. 86:1989;1061-1065.
50. Zebedee S. L., Richardson C. D., Lamb R. A. Characterization of the influenza virus M2 integral membrane protein and expression at the infected cell surface from cloned cDNA. J. Virol. 56:1985;502-511.
51. Zhang J., Lamb R. A. Characterization of the membrane association of the influenza virus matrix protein in living cells. Virology. 225:1996;255-266.