Stereoselective ionic hydrogenation of Vinca alkaloids and vinorelbine in superacids: An access to 4'R-reduced analogs

Tetrahedron Letters

Volumn 39, Issue 45, 1998, Pages 8281-8282

  Lafitte, Cécile ^a   Jouannetaud, Marie Paule ^a   Jacquesy, Jean Claude ^a   Fahy, Jacques ^b   Duflos, Alain ^b  

^a UNIVERSITÉ DE POITIERS   (France)

^b INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANHYDROVINBLASTINE; CYCLOPENTANE; DEOXYVINBLASTINE A; DEOXYVINBLASTINE B; DEUTERIUM; NAVELBINE; UNCLASSIFIED DRUG; VINBLASTINE; VINCA ALKALOID; VINLEUROSINE;

ARTICLE; CHROMATOGRAPHY; HYDROGENATION; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY;

EID: 0032487767     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01889-9     Document Type: Article

References (11)

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2. 2 For a comprehensive review in this area, see: Antitumor Bisindole Alkaloids from Catharanthus roseus (L.). The alkaloids; Brossi, A., Suffness, M., Eds.; Academic Press, Inc.: San Diego, CA 1990; vol.37.
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10. •). Three aromatic hydrogens in A′-ring [7.06 (d, J = 8.5 Hz, 1H-14'), 7.17 (dd, J = 8.5 Hz and J= 1.5 Hz, 1H-13'), 7.62 (s, 1H-11')].
11. 9 G.A. Olah, G.K.S. Prakash, J. Sommer, Superacids; John Wiley and Sons, Inc: New-York, 1985; pp 243-277