Stereoselective alkylations in rigid systems. Effect of remote substituents on π-facial additions to lactam enolates. Stereoelectronic and steric effects

Journal of the American Chemical Society

Volumn 120, Issue 30, 1998, Pages 7429-7438

  Meyers, A I ^a   Seefeld, Mark A ^a   Lefker, Bruce A ^b   Blake, James F ^b   Williard, Paul G ^c  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BICYCLO COMPOUND; LACTAM;

ALKYLATION; ARTICLE; CALCULATION; DRUG SYNTHESIS; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0032486779     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja980614s     Document Type: Article

References (20)

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19. -1 were treated as classical rotations, while imaginary frequencies were ignored. Grev, R. S.; Janssen, C. L.; Schaefer, H. F., III. J. Chem. Phys. 1991, 95, 5128.
20. For a detailed discussion of this procedure, see: Hehre, W. J.; Radom, L.; Schleyer, P. v. R.; Pople, J. A. Ab Initio Molecular Orbital Theory; Wiley: New York, 1986.