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Because of the repulsion between the negative charges, GSH reacts about 5 times slower than the diethyl ester of GSH. See also: Zheng, S.; Newton, G. L.; Gonick, G.; Fancy, R. C.; Ward, J. F. Radiat. Res. 1988, 114, 11.
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3543006704
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note
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2 and GSH. Under these conditions H abstraction from oligonucleotides with subsequent formation of strand cleavage or isomerization products could not be observed by HPLC, although the ketone was consumed within 6 min of irradiation (320 nm cutoff filter).
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3542995232
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note
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2 slower than single-stranded 4'-DNA peroxyl radicals.
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