Removal of proteoglycans increases efficiency of retroviral gene transfer

Biotechnology and Bioengineering

Volumn 58, Issue 1, 1998, Pages 23-34

  Le Doux, Joseph M ^a   Morgan, Jeffrey R ^b,c   Yarmush, Martin L ^b,c  

^a The State University of New Jersey   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c Shriners Burns Institute   (United States)

Author keywords

Gene therapy; Glycosaminoglycans; Proteoglycans; Recombinant retroviruses; Transduction efficiency; Virus concentration

Indexed keywords

BATCH CELL CULTURE; GENETIC ENGINEERING; ION EXCHANGE; SIZE EXCLUSION CHROMATOGRAPHY; ULTRAFILTRATION; VIRUSES;

BATCH ANION EXCHANGE; GLYCOSAMINOGLYCANS; PROTEOGLYCANS; RECOMBINANT RETROVIRUSES; RETROVIRAL GENE TRANSFER; TRANSDUCTION EFFICIENCY; VIRUS INHIBITORY ACTIVITY;

ENZYME INHIBITION;

CHONDROITIN ABC LYASE;

ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; ENZYME ANALYSIS; ENZYME KINETICS; GEL PERMEATION CHROMATOGRAPHY; GENE TRANSFER; GENETIC TRANSDUCTION; NONHUMAN; RETROVIRUS; ULTRAFILTRATION; VIRUS INHIBITION;

3T3 CELLS; ANIMALS; CHONDROITIN ABC LYASE; CHROMATOGRAPHY, GEL; CULTURE MEDIA; GENE TRANSFER TECHNIQUES; GLYCOSAMINOGLYCANS; LAC OPERON; MICE; MOLECULAR WEIGHT; PROTEOGLYCANS; RETROVIRIDAE;

UNIDENTIFIED RETROVIRUS;

EID: 0032485607     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19980405)58:1<23::AID-BIT3>3.0.CO;2-W     Document Type: Article

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