Mutational destabilization of the critical interface water cluster in Scapharca dimeric hemoglobin: Structural basis for altered allosteric activity

Journal of Molecular Biology

Volumn 284, Issue 3, 1998, Pages 729-739

  Pardanani, Animesh ^a,c   Gambacurta, Alessandra ^b   Ascoli, Franca ^b   Royer Jr , William E ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

Author keywords

Allostery; Cooperativity; Hemoglobin; Water

Indexed keywords

CARBON MONOXIDE; DIMER; HEMOGLOBIN; HYDROXYL GROUP; ISOLEUCINE; MUTANT PROTEIN; THREONINE; VALINE; WATER;

ALLOSTERISM; ARTICLE; CLAM; CRYSTAL STRUCTURE; HYDROLYSIS; LIGAND BINDING; NONHUMAN; OXYGEN AFFINITY; PRIORITY JOURNAL; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

BIVALVIA; SCAPHARCA; SCAPHARCA INAEQUIVALVIS;

EID: 0032484033     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2195     Document Type: Article

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