Novel angucycline compound with both antigastrin- and gastric mucosal protective-activities

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 15, 1998, Pages 1969-1972

  Uesato, Shinichi ^a   Tokunaga, Takashi ^b   Takeuchi, Koji ^c  

^a KANSAI UNIVERSITY   (Japan)

^b JAPAN TOBACCO INC   (Japan)

^c KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANGUCYCLINE DERIVATIVE; ANGUCYCLINE P371 A1; GASTRIN; HYDROCHLORIC ACID; INDOMETACIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; STEREOCHEMISTRY; STOMACH ACID SECRETION; STOMACH LESION; STOMACH MUCOSA; STOMACH PROTECTION; STRUCTURE ACTIVITY RELATION;

AMINOGLYCOSIDES; ANIMALS; ANTI-BACTERIAL AGENTS; GASTRIC MUCOSA; GASTRINS; HISTAMINE H2 ANTAGONISTS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; RATS; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032483138     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00340-0     Document Type: Article

References (15)

1. 1. Garner, A., Scand. J. Gastroenterol., 1986, 21, 203.
2. 2. Larsson, H.; Carlsson, E.; Ryberg, B.; Fryklund, J.; Wallmark, B., Am. J. Physiol., 1988, 254, G33.
3. 3. Makovec, F.; D'Amato, M., Drug Discovery Today, 1997, 2, 283.
4. 2O solution (pH 7.0).
5. 5. The strain P371 has been deposited at the National Institute of Bioscience and Human Technology, Agency of Industrial Science and Technology, Ibaraki Pref. Japan, as under the accession number FERM BP-4146.
6. 6. Drautz, H.; Zähner, H., J. Antibiotics, 1986, 39, 1657.
7. 7 Martin, A.; Pais, M.; Monneret, C., Carbohydrate Research, 1983, 113, 189.
8. 8. Thiem, J.; Elvers, J., Chem. Ber., 1981, 114, 1442.
9. 6 in 1 is under investigation, and will be reported elsewhere.
10. 10. Kato, S.; Kitamura, M.; Korolkiewicz, R. P.; Takeuchi, K., Bri. J. Pharmacol., 1998, 123, 839.
11. 11. Daly, M. J.; Humphray, J. M.; Stables, R., Gut., 1980, 21, 408.
12. 12. Wallmark, B., Methods Find. Exp. Clin. Pharmacol., 1989, 11 (suppl), 101.
13. 13. Hirschowitz, B. I.; Keeling, D.; Lewin, M.; Okabe, S.; Parsons, M.; Sewing, K.; Wallmark, B.; Sacks, G., Dig. Dis. Sci., 1995, 40, 3S.
14. 14. Nishida, A.; Miyata, K.; Tsutsumi, R.; Yuki, H.; Akuzawa, S.; Kobayashi, A.; Kamato, T.; Ito, H.; Yamano, M.; Katuyama, Y.; Satoh, M.; Ohta, M.; Honda, K., J. Pharmacol. Exp. Ther., 1994, 269, 725.
15. 15. Sandvik, A. K.; Waldum, H. L.; Kleveland, P. M.; Schulze, S. B., Scand. J. Gastroenterol., 1987, 22, 803.