Selective enzymatic acylation of 10-deacetylbaccatin III

Tetrahedron Letters

Volumn 39, Issue 49, 1998, Pages 9039-9042

  Lee, Donghyun ^a   Kim, Kyung Chul ^a   Kim, Mahn Joo ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BACCATIN III; DICHLOROACETIC ACID; TRIACYLGLYCEROL LIPASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BURKHOLDERIA CEPACIA; CATALYSIS; CATALYST; DRUG ACETYLATION; DRUG POTENCY; ENZYME SPECIFICITY; STRUCTURE ACTIVITY RELATION;

BURKHOLDERIA; BURKHOLDERIA CEPACIA; PSEUDOMONAS;

EID: 0032481077     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02049-8     Document Type: Article

References (20)

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18. 3N (0.134mL, 12 eq.), and DCAA (0.115mL, 6 eq.). The resulting heterogeneous mixture was allowed to stirr at room temperature until the starting material was disappeared on TLC. The solution was filterd on celite to remove the enzymes and then subjected to flash chromatography to yield 7 (53.1mg, 0.07mmol) in 86% yield.
19. 3SiNa (M + Na): 805.2489 Found: 805.2522.
20. 8. No detectable chemical acylations due to the presence of triethylamine were observed for 1 day in the control reactions without enzymes.