Mice with type 2 and 3 gaucher disease point mutations generated by a single insertion mutagenesis procedure (SIMP)

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 5, 1998, Pages 2503-2508

  Liu, Yujing ^a   Suzuki, Kinuko ^c   Reed, Jennifer D ^a   Grinberg, Alexander ^b   Westphal, Heiner ^b   Hoffmann, Alexander ^d   Döring, Thomas ^d   Sandhoff, Konrad ^d   Proia, Richard L ^a,e  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF BONN   (Germany)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Gene targeting; Lysosomal storage disease; Mouse model; Sphingolipidosis

Indexed keywords

GLUCOSYLCERAMIDE; GLYCOSYLCERAMIDASE; LYSOSOME ENZYME;

ANIMAL CELL; ANIMAL MODEL; CONFERENCE PAPER; DISEASE COURSE; DISEASE SEVERITY; ENZYME DEFICIENCY; GAUCHER DISEASE; GENE EXPRESSION REGULATION; GENE MUTATION; GENE TARGETING; GENE THERAPY; GENETIC RECOMBINATION; LIPIDOSIS; LYSOSOME STORAGE DISEASE; MARKER GENE; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PATHOGENESIS; POINT MUTATION; PRIORITY JOURNAL;

EID: 0032478309     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.5.2503     Document Type: Article

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