Anti-malarial activities of acylated bruceolide derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 5, 1998, Pages 459-462

  Murakarni, Nobutoshi ^a   Umezome, Takashi ^a   Mahmud, Taifo ^a   Sugimoto, Masanori ^a   Kobayashi, Motomasa ^a   Wataya, Yusuke ^b   Kim, Hye Sook ^b  

^a OSAKA UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; BRUCEOLIDE; BRUCEOLIDE DERIVATIVE; GLYCOSIDE; NATURAL PRODUCT; UNCLASSIFIED DRUG; YADANZIOSIDE;

ANTIMALARIAL ACTIVITY; ARTICLE; CHINESE HERB; CONTROLLED STUDY; DRUG EFFECT; DRUG SELECTIVITY; DRUG SYNTHESIS; MALARIA; NONHUMAN;

ACYLATION; ANIMALS; ANTIMALARIALS; GLAUCARUBIN; MICE; PLASMODIUM FALCIPARUM; TUMOR CELLS, CULTURED;

EID: 0032478058     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00045-6     Document Type: Article

References (10)

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7. 7. All new compounds were spectrally characterized, and full preparative details and characteristics will be presented in a full paper on this subject. Each derivative (3b-3p) was prepared from 2 in the following yield: 3b (55 %), 3c (92 %), 3d (90 %), 3e (83 %), 3f (52 %), 3g (68 %), 3h (75 %), 3i (32 %), 3j (29 %), 3k (97 %), 31 (35 %), 3m (37 %), 3n (63 %), 3o (84 %), 3p (69 %).
8. 8. Although bruceine B (3a) was reported to show inhibitory activity against chloroquine-resistant strains of P. falciparum, selective toxicity of 3a has not been examined. Ref. Kirby, G. C.; O'Neill, M. J.; Phillipson, J. D.; Warhurst, D. C. Biochem. Pharmacol. 1989, 38, 4367-4374.
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