Interpreting the effect of methyl group at the three carbon bridge of (-)-huperzine A on its anticholinesterase activity by molecular dynamics method

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 5, 1998, Pages 419-422

  Liu, DongXiang ^a   Jiang, HuaLiang ^a   Wang, QinMi ^a   Chen, KaiXian ^a   Ji, RuYun ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; HUPERZINE A; METHYL GROUP;

ARTICLE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HYDROGEN BOND; MOLECULAR DYNAMICS; NONHUMAN;

CHOLINESTERASE INHIBITORS; HYDROGEN BONDING; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032478057     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00042-0     Document Type: Article

References (8)

1. 1. Kozikowski, A.P.; Xia, Y.; Reddy, E.R.; Tuckmantel, W.; Hanin, I.; Tang, X.C.. J. Org. Chem., 1991, 56, 4636.
2. 2. Campiani, G.; Sun, L.Q.; Kozikowski, A.P.; Aagaard, P.; McKinney, M.. J. Org. Chem., 1993, 58, 7660.
3. 3. Kozikowski, A.P.; Miller, C.P.; Yamada, F.; Pang, Y.P.; Miller, J.H.; McKinney, M.; Ball, R.G.. J. Med. Chem., 1991, 34, 3399.
4. 4. Raves, M.L.; Harel, M.; Pang, Y.P.; Silman, I.; Kozikowski, A.P.; Sussman, J.L.. Nature Structural Biology, 1997, 4(1), 57.
5. 5. Kaneko, S.; Nakajima, N.; Shikano, M.; Katoh, T.; Terashima, S.. Bioorganic & Medicinal Chemistry Letters, 1996, 6(16), 1927.
6. 6. Sussman, J.L.; Seeman, N.C.; Kim, S.H.; Berman, H.M.. J. Mol. Biol., 1972, 66, 403.
7. 7. Taylor, R.; Kennard, O.. J. Am. Chem. Soc., 1982, 104, 5063.
8. 8. Derewenda, Z.S.; Derewenda, U.; Kobos, P.M.. J. Mol. Biol., 1994, 241, 83.