Structure activity relationship study of known inhibitors of the enzyme 5α-reductase (5AR)

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 5, 1998, Pages 409-414

  Ahmed, Sabbir ^a   Denison, Sophie ^a  

^a KINGSTON UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANOLONE; ENZYME INHIBITOR; FINASTERIDE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; HYDROGEN BOND; HYPOTHESIS; MOLECULAR MODEL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

CHOLESTENONE 5 ALPHA-REDUCTASE; ENZYME INHIBITORS; HYDROGEN BONDING; MOLECULAR STRUCTURE; OXIDOREDUCTASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032478048     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00044-4     Document Type: Article

References (8)

1. 1. Rasmusson, G. H., Reynolds, G. F., Utne, T., Jobson, R. B., Primka, R. L., Berman, C., and Brooks, J. R., J. Med. Chem., 27, 1690-1701, 1984.
2. 2. Holt, D. A., Levy, M. A., Yen, H. -K., OH, H. -J., Metcalf, B. W., and Weir, P. J., Bioorg. Med. Chem. Lett. 1, 27-32, 1991.
3. 3. Rasmusson, G. H., Reynolds, G. F., Steinberg, N. G., Walton, E., Patel, G. F., Liang, T. M., Cascieri, M. A., Cheung, A. H., Brooks, J. R., Berman, C., J. Med. Chem., 29, 11, 2298-2315, 1986.
4. 4. Alchemy III and Powersearch, Tripos Associates Inc., 1699 South Hanley Road, Suite 303, St. Louis, Missouri 63144, USA.
5. 5. Potter, G. A., Barrie, S. E., Jarman, M., and Rowlands, M. G., J. Med. Chem. 38, 2463-2471, 1995.
6. 6. McDonald, I. A., Nyce, P. L., Muench, D. M., Gates, C. A., Blohm, T. R., Laughlin, M. E., Weintraub, P. M., Bioorg. Med. Chem. Lett. 4, 847-851, 1994.
7. 7. Jones, C. D., Audia, J. E., Lawhorn, D. E., McQuaid, L. A., Neubauer, B. L., Pike, A. J., Pennington, P. A., Stamm, N. B., Toomey, R. E., and Hirsch, K. S., J. Med. Chem. 36, 421-423, 1993.
8. 8. Holt, D. A., Yamashita, D. S., Konialian-Beck, A. L., Luengo, J. I., Brandt, M., Levy, M. A., Bergsma, D. J., Abell, A. D., J. Med. Chem. 38, 13-15, 1995.