An alternative synthesis of 4,4-dimethyl-5α-cholesta-8,14,24-trien-3β-ol, an intermediate in sterol biosynthesis and a reported activator of meiosis and of nuclear orphan receptor LXR

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 3, 1998, Pages 233-236

  Ruan, B ^a   Wilson, W K ^a   Schroepfer Jr , G J ^a  

^a RICE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4 DIMETHYL 5ALPHA CHOLESTA 8,14,24 TRIEN 3BETA OL; LANOSTEROL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTIAL DRUG SYNTHESIS; REACTION ANALYSIS; STEROL SYNTHESIS;

CHOLESTENES; DNA-BINDING PROTEINS; MEIOSIS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STEROLS;

EID: 0032477688     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00016-X     Document Type: Article

References (19)

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8. 1H NMR, δ 0.800 (H-19), 0.969 (H-18), 0.994 (H-21).
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12. 1H NMR, δ 0.801 (H-19), 0.977 (H-18), 1.020 (H-21).
13. 1H NMR, δ 0.801 (H-19), 0.978 (H-18), 1.004 (H-21).
14. 1H NMR, δ 0.801 (H-19), 0.969 (H-18), 1.013 (H-21).
15. 1H NMR, δ 0.805 (H-19), 1.022 (H-18), 0.942 (H-21).
16. 1HNMR, δ 1.054 (H-19), 0.807 (H-18), 0.955 (H-21).
17. 1H NMR, δ 1.034 (H-19), 0.810 (H-18), 0.955 (H-21).
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19. 15. It should be noted that this synthetic approach provides the basis for a relatively simple synthesis of isotopically substituted I in which the isotopic label is introduced via a suitably labeled Wittig reagent at a late stage in the synthesis of I.