Effect of low-intensity 50-Hz magnetic fields on kindling acquisition and fully kindled seizures in rats

Brain Research

Volumn 809, Issue 2, 1998, Pages 269-276

  Potschka, Heidrun ^a   Thun Battersby, Susanne ^a   Löscher, Wolfgang ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Anticonvulsant; Electromagnetic field; Epilepsy

Indexed keywords

ANTICONVULSIVE AGENT;

ALTERNATING CURRENT; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIRECT CURRENT; ELECTROMAGNETIC FIELD; ELECTROSTIMULATION; EPILEPSY; FASCICULATION; KINDLING; LONG TERM EXPOSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SYNAPTIC TRANSMISSION; TRANSCRANIAL MAGNETIC STIMULATION;

AMYGDALA; ANIMALS; ELECTRIC STIMULATION; ELECTROMAGNETIC FIELDS; EPILEPSY; FEMALE; KINDLING, NEUROLOGIC; MICROELECTRODES; RATS; RATS, WISTAR;

EID: 0032476769     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00919-6     Document Type: Article

References (41)

1. Adey W.R. Biological effects of electromagnetic fields. J. Cell. Biochem. 51:1993;410-416.
2. Albertson T.E., Joy R., Stark L.G. Carbamazepine: a pharmacological study in the kindling model of epilepsy. Neuropharmacology. 23:1984;1117-1123.
3. Albertson T.E., Peterson S.L., Stark L.G., Lakin M.L., Winters W.D. The anticonvulsant properties of melatonin on kindled seizures in rats. Neuropharmacology. 20:1981;61-66.
4. Albertson T.E., Walby W.F. The anticonvulsant action of AHR-11748 on kindled amygdaloid seizures in rats. Epilepsy Res. 1:1987;126-133.
5. Aldrich T.E., Laborde D., Griffith J., Easterly C. A meta-analysis of the epidemiological evidence regarding human health risk associated with exposure to electromagnetic fields. Electro. Magnetobiol. 11:1992;127-143.
6. Anninos P.A., Tsagas N., Sandyk R., Derpapas K. Magnetic stimulation in the treatment of partial seizures. Int. J. Neurosci. 60:1991;141-171.
7. Baum A., Mevissen M., Kamino K., Mohr U., Löscher W. A histopathological study on alterations in DMBA-induced mammary carcinogenesis in rats with 50 Hz, 100 μT magnetic field exposure. Carcinogenesis. 16:1995;119-125.
8. Bureau Y.R.J., Persinger M.A. Decreased latencies for limbic seizures induced in rats by lithium-pilocarpine occur when daily average geomagnetic activity exceeds 20 nanoTesla. Neurosci. Lett. 192:1995;142-144.
9. Classen J., Witte O.W., Schlaug G., Seitz R.J., Holthausen H., Benecke R. Epileptic seizures triggered directly by focal transcranial magnetic stimulation. Electroencephalogr. Clin. Neurophysiol. 94:1995;19-25.
10. B. Floderus, Occupational studies, in: R. Matthes, J.H. Bernhardt, M.H. Repacholi (Eds.), Biological Effects of Static and ELF Electric and Magnetic Fields, Märkl, Munich, 1997, pp. 193-201.
11. Freeman F.G., Jarvis M.F. The effect of interstimulation interval on the assessment and stability of kindled seizure threshold. Brain Res. Bull. 7:1981;629-633.
12. Fuller M., Dobson J., Wieser H.G., Moser S. On the sensitivity of the human brain to magnetic fields: evocation of epileptiform activity. Brain Res. Bull. 36:1995;155-159.
13. Hendee W.R., Boteler J.C. The question of health effects from exposure to electromagnetic fields. Health Physics. 66:1994;127-136.
14. Juutilainen J., Bjork E., Saali K. Epilepsy and electromagnetic fields: effects of simulated atmospherics and 100-Hz magnetic fields on audiogenic seizure in rats. Int. J. Biometereol. 32:1988;17-20.
15. Kato M., Honma K.I., Shigemitsu T., Shiga Y. Effects of exposure to a circulatory polarized 50-Hz magnetic field on plasma and pineal melatonin levels in rats. Bioelectromagnetics. 14:1993;97-106.
16. Kavaliers M., Ossenkopp K.-P. Stress-induced opioid analgesia and activity in mice: inhibitory influences of exposure to magnetic fields. Psychopharmacology. 89:1986;440-443.
17. Kavaliers M., Ossenkopp K.-P. Magnetic fields and stress: day-night differences. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 11:1987;279-286.
18. Löscher W., Hönack D. Anticonvulsant and antiepileptogenic effect of L-deprenyl (selegiline) in the kindling model of epilepsy. J. Pharmacol. Exp. Ther. 274:1995;307-314.
19. Löscher W., Liburdy R.P. Animal and cellular studies on carcinogenic effects of low frequency (50/60-Hz) magnetic fields. Mutation Res. 410:1998;185-220.
20. Löscher W., Hönack D., Rundfeldt C. Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. J. Pharmacol. Exp. Ther. 284:1998;474-479.
21. Löscher W., Wahnschaffe U., Mevissen M., Lerchl A., Stamm A. Effects of weak alternating magnetic fields on nocturnal melatonin production and mammary carcinogenesis in rats. Oncology. 51:1994;288-295.
22. M.J. McLean, R.R. Holcomb, R.M. Thomas, Therapeutic efficacy of a static magnetic device in three animal seizure models: summary of experience, Abstracts of the Second World Congress for Electricity and Magnetism in Biology and Medicine, Bologna, June 8-13, 1997, (1997), pp. 135-136.
23. Merritt R., Purcell C., Stroink G. Uniform magnetic fields produced by three, four, and five square coils. Rev. Sci. Instrum. 54:1983;879-882.
24. Mevissen M., Lerchl A., Löscher W. Study on pineal function and DMBA-induced breast cancer formation in rats during exposure to a 100-mG, 50-Hz magnetic field. J. Toxicol. Environ. Health. 48:1996;101-117.
25. Michon A.L., Persinger M.A. Experimental simulation of the effects of increased geomagnetic activity upon nocturnal seizures in epileptic rats. Neurosci. Lett. 224:1997;53-56.
26. Ossenkopp K.-P., Cain D.P. Inhibitory effects of acute exposure to low-intensity 60-Hz magnetic fields on electrically kindled seizures in rats. Brain Res. 442:1988;255-260.
27. Ossenkopp K.-P., Cain D.P. Inhibitory effects of power-line frequency (60-Hz) magnetic fields on pentylenetetrazol-induced seizures and mortality in rats. Behav. Brain Res. 44:1991;211-216.
28. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, Sydney, 1986
29. Persinger M.A. Enhancement of limbic seizures by nocturnal application of experimental magnetic fields that simulate the magnitude and morphology of increases in geomagnetic activity. Int. J. Neurosci. 86:1996;271-280.
30. Peterson S.L., Albertson T.E., Stark L.G., Joy R.M., Gordon L.S. Cumulative afterdischarge as the principal factor in the acquisition of kindled seizures. Electroencephalogr. Clin. Neurophysiol. 51:1981;192-200.
31. Racine R.J. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalogr. Clin. Neurophysiol. 32:1972;281-294.
32. R.J. Racine, G.O. Ivy, N.W. Milgram, Kindling: clinical relevance and anatomical substrate, in: T.G. Bolwig, M.R. Trimble (Eds.), The Clinical Relevance of Kindling, Wiley, Chichester, 1989, pp. 15-34.
33. Ruhenstroth-Bauer G., Vogl S., Baumer H., Moritz C., Weinmann H.M. Natural atmospherics and occurrence of seizures in six adolescents with epilepsy: a cross correlation study. Seizure. 4:1995;303-306.
34. Sandyk R., Anninos P.A. Attenuation of epilepsy with application of external magnetic fields: a case report. Int. J. Neurosci. 66:1992;75-85.
35. D.A. Savitz, A. Ahlbom, Epidemiologic evidence on cancer in relation to residential and occupational exposures, in: D.O. Carpenter, S. Ayrapetyan (Eds.), Biological Effects of Electric and Magnetic Fields, Academic Press, San Diego, 1994, pp. 233-261.
36. Selmaoui B., Touitou Y. Sinusoidal 50-Hz magnetic fields depress rat pineal NAT activity and serum melatonin. Role of duration and intensity of exposure. Life Sci. 57:1995;1351-1358.
37. Sobel E., Davanipour Z. Electromagnetic field exposure may cause increased production of amyloid beta and eventually lead to Alzheimer's disease. Neurology. 47:1996;1594-1600.
38. Sobel E., Davanipour Z., Sulkava R., Erkinjuntti T., Wikstrom J., Henderson V.W., Buckwalter G., Bowman J.D., Lee P.J. Occupations with exposure to electromagnetic fields: a possible risk factor for Alzheimer's disease. Am. J. Epidemiol. 142:1995;515-524.
39. Sobel E., Dunn M., Davanipour Z., Qian Z., Chui H.C. Elevated risk of Alzheimer's disease among workers with likely electromagnetic field exposure. Neurology. 47:1996;1477-1481.
40. Stone W.S., Eggleton C.E., Berman R.F. Opiate modification of amygdaloid-kindled seizures in rats. Pharmacol. Biochem. Behav. 16:1982;751-756.
41. M.A. Stuchly, Exposure to static and time-varying magnetic fields in industry, medicine, research and public life. Dosimetric aspects, in: J.H. Bernhardt (Ed.), Biological Effects of Static and Extremely Low Frequency Magnetic Fields, MMV Medizin Verlag, Munich, 1986, pp. 39-56.