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15
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33847450203
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3) was obtained in 57% yield. The structure and formation mechanism of this product will appear in a separate paper. (Figure Presented) 13 : R=CO2Et
-
3) was obtained in 57% yield. The structure and formation mechanism of this product will appear in a separate paper. (Figure Presented) 13 : R=CO2Et
-
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16
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0015491738
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33744715743
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note
-
Column (Chiralcol OJ, Daiccl Chem. Ind. Ltd.), 25 ×0.46 (i.d) cm stainless tube packed with cellulose esters coated on silica gel; flow rate, 0.5 mL/min at 20 °C; solvent, 'PrOH-n-hexane (1:1); detector, a UV-detector at 254 nm; rt, 26.4 min. A trace of (-)-enantiomer (<1%) of tilivalline 1, probably due to the impurity of the starting (S)-proline, was detected; rt, 30.9 min. These chromatograms were carefully checked by (±)- and (+Milivallines, prepared from (±)- and (S)-(-)-prolines, respectively.
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19
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0342887207
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24
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33847488837
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-
9 needs the addition of a catalytic amount of ethanol solution containing hydrogen chloride at regular intervals. Reduction of 6a and 6b with sodium borohydride in ethanol and tetrahydrofuran, however, could be also accomplished without addition of acid.
-
9 needs the addition of a catalytic amount of ethanol solution containing hydrogen chloride at regular intervals. Reduction of 6a and 6b with sodium borohydride in ethanol and tetrahydrofuran, however, could be also accomplished without addition of acid.
-
-
-
-
27
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0023787140
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Tsunakawa, M.; Kamei, H.; Konishi, M.; Miyaki, T.; Oki, T.; Kawaguchi, H. J. Antibiotics 1988, 1366.
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Oki, T.5
Kawaguchi, H.J.6
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