Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases

FEBS Letters

Volumn 436, Issue 2, 1998, Pages 209-212

  Krumme, Dirk ^a   Wenzel, Herbert ^a   Tschesche, Harald ^a  

^a BIELEFELD UNIVERSITY   (Germany)

Author keywords

Aminomalonic acid; Hydroxamate; Inhibition; Matrix metalloproteinase; Peptide inhibitor

Indexed keywords

COLLAGENASE; GELATINASE B; HYDROXAMIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE INHIBITOR;

ARTICLE; ENZYME KINETICS; PRIORITY JOURNAL; SPECTROSCOPY;

COLLAGENASES; HUMANS; HYDROXAMIC ACIDS; KINETICS; MATRIX METALLOPROTEINASE 8; MATRIX METALLOPROTEINASE 9; OLIGOPEPTIDES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0032475895     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(98)01128-4     Document Type: Article

References (16)

1. Birkedal-Hansen H., Moore W.G.I., Bodden M.K., Windsor L.J., Birkedal-Hansen B., DeCarlo A., Engler J.A. Crit. Rev. Oral Biol. Med. 4:1993;197-250.
2. Johnson W.H., Roberts N.A., Borkakoti N. J. Enzyme Inhib. 2:1987;1-22.
3. Schwartz M.A., Van Wart H.E. Prog. Med. Chem. 29:1992;271-334.
4. Bode W., Reinemer P., Huber R., Kleine T., Schnierer S., Tschesche H. EMBO J. 13:1992;1263-1269.
5. Grams F., Crimmin M., Hinnes L., Huxley P., Pieper M., Tschesche H., Bode W. Biochemistry. 34:1995;14012-14020.
6. Borkakoti N., Winkler F.K., Williams D.H., D'Arcy A., Broadhurst M.J., Brown P.A., Johnson W.H., Murray E.J. Struct. Biol. 1:1994;106-110.
7. Spurlino J.C., Smallwood A.M., Carlton D.D., Banks T.M., Vavra K.J., Johnson J.S., Cook E.R., Falvo J., Wahl R.C., Pulvino K.J., Wendoloski J.J., Simth D.L. Proteins Struct. Funct. Genet. 19:1994;98-109.
8. Schechter I., Berger A. Biochem. Biophys. Res. Commun. 27:1967;157-162.
9. Krumme, D. (1995) Diplomarbeit, Universität Bielefeld.
10. Tschesche H., Knäuper V., Krämer S., Michaelis J., Oberhoff R., Reinke H. Matrix Suppl. 1:1992;245-255.
11. Schnierer S., Kleine T., Gote T., Hillemann A., Knäuper V., Tschesche H. Biochem. Biophys. Res. Commun. 191:1993;319-326.
12. Knight C.G., Willenbrock F., Murphy G. FEBS Lett. 296:1992;263-266.
13. Dixon M. Biochem. J. 55:1953;170-171.
14. Weingarten H., Martin R., Feder J. Biochemistry. 24:1985;6730-6734.
15. Fields G.B., Van Wart H.E., Birkedal-Hansen H. J. Biol. Chem. 262:1973;6221-6226.
16. Netzel-Arnet S., Fields G., Birkedal-Hansen H., Van Wart H.E. J. Biol. Chem. 266:1991;6747-6755.