1,4-Diaminobutanes from furans: A new synthetic approach to substituted putrescines

Tetrahedron Letters

Volumn 39, Issue 27, 1998, Pages 4765-4768

  Frydman, Benjamin ^a   Ojea, Maria I ^b  

^a S'LIL Pharmaceuticals LLC   (United States)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

FURAN DERIVATIVE; PUTRESCINE DERIVATIVE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 0032474798     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00903-4     Document Type: Article

References (29)

1. 1. Aizencang, G.; Frydman, R. B.; Giogieri, S.; Sambrotta, L.; Guerra, L.; Frydman, B. J. Med. Chem. 1995; 38, 4337-4341, and references therein.
2. 2. Cohen, S. S. A guide to the polyamines. Oxford, 1998.
3. 3. Alonso Garrido, D. O.; Buldain, G.; Ojea, M. I.; Frydman B. J. Org. Chem. 1988, 53 , 403-407.
4. 4. Alonso Garrido, D. O.; Buldain, G.; Frydman, B. J. Org. Chem. 1984, 49, 2619-2623.
5. 5. Samejima, K.; Matsushima, N.; Niitsu, M.; Beppu, T.; Frydman, B. Chem. Pharm. Bull. 1995, 43, 2001-2004.
6. 6. Gershon, H.; Rodin, R. J. Med. Chem. 1965, 8, 864-866.
7. 7. Marecek, J. F., Burrows, C.J. Tetrahedron Lett. 1986, 27, 5943-5946.
8. 8. Salituro, F. G.; Agarwal, N.; Hoffmann, T.; Rich, D.H. J. Med. Chem. 1987, 30, 286-295.
9. 9. Clauson-Kaas, N.; Limburg, F.; Fakstorp, J. Acta Chem. Scand. 1948, 2, 109-115.
10. +).
11. +).
12. 12. Howard, W.L.; Brown, Jr., J.H. J. Org. Chem. 1961, 26, 1026-1028.
13. 13. Jones, T.H.; Highet, R.J.; Don, A.W.; Blum, M.S. J. Org. Chem. 1986, 51, 2712-2716.
14. 2), 154.23, 154.39, 154.95 (C=NOH), 170.53 (CO).
15. 3).
16. 16. Finan, P.A. J. Chem. Soc. 1963, 3917-3918.
17. 5), 169.68 (CO).
18. 2H, 100%).
19. ++1).
20. 20. Holfinger, M.S.; Conner, A.H.; Holm, D.R.; and Hill, Jr., C.G. J. Org. Chem. 1995, 60, 1595-1598.
21. 2O), 96.24 (O-CH-O), 106.76, 109.05 (furan-C), 126.98, 127.18, 127.41, 134.44 (Ph), 150.36, 151.28 (furan-C), 155.37 (CO).
22. 2O), 93.74 (O-CH-O), 98.67, 98.79 (C=C), 110.53, 111.70, 127.32, 127.54, 127.69, 132.66, 156,03 (CO).
23. 3O), 61.44, 64.01, 69.02, 97.22, 110.53, 111.70, 127.32, 127.55, 127.67, 135.60, 154.46.
24. 2O), 127.67, 127.76, 128.75, 135.97 (Ph), 151.66, 152.02 (C=NOH), 156.61 (CO).
25. ++1).
26. 4).
27. 5), 124.75, 125.28 (CH=C), 141.82, 142.44 (C=CH).
28. 5).
29. 2O).