Anti-Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 11, 1998, Pages 1307-1312

  Katsura, Yousuke ^a,b   Nishino, Shigetaka ^a   Tomishi, Tetsuo ^a   Sakane, Kazuo ^a   Matsumoto, Yoshimi ^b   Ishikawa, Hirohumi ^b   Takasugi, Hisashi ^a  

^a Med Chem Res Labs and Med B   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Antimicrobial compels; Gastrointestinal activity

Indexed keywords

AMOXICILLIN; BISMUTH SALICYLATE; CIMETIDINE; CYCLOHEXYMETHYL DERIVATIVE; ETHOXYETHYL DERIVATIVE; FURYLTHIAZOLE DERIVATIVE; GUANIDINE DERIVATIVE; METRONIDAZOLE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DOG; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; GASTROINTESTINAL SECRETION; GUINEA PIG; HELICOBACTER PYLORI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; DOGS; GASTRIC ACID; GUANIDINES; GUINEA PIGS; HEART ATRIA; HELICOBACTER PYLORI; HISTAMINE H2 ANTAGONISTS; MICROBIAL SENSITIVITY TESTS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 0032474514     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00206-6     Document Type: Article

References (16)

1. [1] Axon ATR. Scand J. Gastroenterol. 1996;31:Suppl 214:47-53.
2. [2] Lany KL, Tanaka K. Ann. Rep. Med Chem. 1995;151-158.
3. [3] Marshall BJ. Am. J. Gastroenterol. 1994;89:s116-s128.
4. [4] Alper J. Science 1993;260:159-160.
5. [5] Heatley RV. Aliment. Pharmacol. Ther. 199;6:291-303.
6. [6] Chiba N, Rao BV, Rademaker JW, Hunt RH. Am. J. Gastroenterol. 1992;87:1716-1727.
7. [7] Dooley CP. Aliment. Pharmacol. Ther. 1991;5:Suppl. 1:129-143.
8. [8] Blum AL. Scand. J. Gastroenterol. 1996;31:Suppl 214:24-27.
9. [9] Tytgat GNJ, Lee A, Graham DY, Dixon MF, Rokkas T. Gastroenterology International 1993;6:76-89.
10. [10] Ateshkadi A, Lam NP, Johnson CA. Clin. Pharm, 1993;12:34-38.
11. [11] Fletcher PJ, Craig QM. J. Clin. Pharm. Ther. 1993;18:311-316.
12. [12] Partipilio ML, Woster PS. Pharmacotherapy 1993;13:330-339.
13. [13] Glupczynski Y, Burette A. Am. J. Gastroenterol. 1990;85:1545-1551.
14. [14] NIH consensus development panel on Helicobacter pylori in peptic ulcer disease. J. Am. Med. Assoc. 1994;272:65-69.
15. [15] Katsura Y, Tomishi T, Inoue Y, Sakane K, Matsumoto Y, Ishikawa H, Takasugi H. J. Med. Chem. 1997;40:2462-2465.
16. [16] Katsura Y, Inoue Y, Tomishi T, Itoh H, Ishikawa H, Takasugi H. Chem. Pharm. Bull. 1992;40:2432-2441.