The novel cyclopropapyrroloindole(CPI) bisalkylators bearing methoxycarbonyl and trifluoromethyl groups

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 11, 1998, Pages 1387-1390

  Fukuda, Yasumichi ^a   Furuta, Hirosuke ^a   Kusama, Yoshie ^a   Ebisu, Hiroyuki ^a   Oomori, Yasuo ^a   Terashima, Shiro ^b  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

^b SAGAMI CHEMICAL RESEARCH CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHOXYCARBONYL 2 TRIFLUOROMETHYLCYCLOPROPAPYRROLOINDOLE; 4 CHLOROMETHYL 1,4,5,6 TETRAHYDRO 6 [5 [(7 METHOXYBENZOFURAN 2 YLCARBONYL)AMINO] 1H INDOL 2 YLCARBONYL] 8 [(4 METHYL 1 PIPERAZINYLCARBONYL)OXY] 2 TRIFLUOROMETHYLPYRROLO[3,2 E]INDOLE 3 CARBOXYLIC ACID METHYL ESTER; ANTINEOPLASTIC AGENT; BIZELESIN; CARZELESIN; CISPLATIN; INDOLE DERIVATIVE; PIBROZELESIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MICE; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; UREA;

EID: 0032474513     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00235-2     Document Type: Article

References (15)

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