The first conversion of camptothecin to (S)-mappicine by an efficient chemoenzymatic method

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 11, 1998, Pages 1403-1406

  Das, Biswanath ^a   Madhusudhan, P ^a   Kashinatham, A ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; MAPPICINE; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME MECHANISM; MICROWAVE IRRADIATION; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ALKALOIDS; CAMPTOTHECIN; MICROWAVES; SACCHAROMYCES CEREVISIAE; STEREOISOMERISM;

EID: 0032474497     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00234-0     Document Type: Article

References (18)

1. 1. Part IV in the series "Biochemical Studies on Natural Products"; for Part III see ref. 7b, IICT Communication No. 3961.
2. 2. a) Govindachari, T. R., Ravindranath, K. R.; Viswanathan, N. J. Chem. Soc. Perkin Trans I 1974, 1215;
3. 3-MeOH, 4:1).
4. 3. a) Adamovics, J. A.; Cina, J. A.; Hutchinson, C. R. Phytochemistry 1979,18, 1085;
5. b) Kingsbury, W. D. Tetrahedron Lett. 1988, 29, 6847.
6. 4. a) Kametani, T.; Takeda, H; Nemoto, H.; Fukumoto, K. Heterocycles, 1975, 3, 167;
7. b) Kametani T.; Takeda, H; Nemoto, H.; Fukumoto, K. J. Chem. Soc. Perkin Trans I, 1975, 1825;
8. c) Comins, D. L.; Saha, J. K. J. Org. Chem., 1996, 61, 9623.
9. 5. a) Josien, H.; Curran, D. P. Tetrahedron, 1997, 53, 8881;
10. b) Boger, D. L.; Hong, J. J. Am. Chem. Soc., 1998, 120, 1218.
11. 6. a) Das, B.; Rao, S. P.; Kashinatham, A; Srinivas, K. V. N. S. Indian J. Chem., 1997, 36B, 208;
12. b) Das, B.; Anjani, G.; Kashinatham, A.; Madhusudhan, P. Nat. Prod Lett., 1997 (accepted);
13. c) Das, B.; Madhusudhan, P.; Kashinatham, A. Tetrahedron Lett., 1998, 39, 431.
14. 7. a) Das, B; Rao, S. P.; Srinivas, K. V. N. S.; Yadav, J. S. Phytochemistry, 1993, 33, 1529;
15. b) Das, B; Kashinatham A; Madhusudhan, P. Tetrahedron Lett., 1997, 38, 7457.
16. 2b
17. 2b. The recovered unreacted mappicine ketone (3) (12 mg) could again be utilized for baker's yeast reduction.
18. 9. Hutchinson, C. R. Tetrahedron, 1981, 37, 1047.