The synthesis of allyl- and allyloxycarbonyl-protected RNA phosphoramidites. Useful reagents for solid-phase synthesis of RNAs with base-labile modifications

Tetrahedron Letters

Volumn 39, Issue 14, 1998, Pages 1897-1900

  Bogdan, Felicia M ^a   Chow, Christine S ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHORAMIDIC ACID DERIVATIVE;

ARTICLE; BASE PAIRING; CELL FREE SYSTEM; CHEMICAL MODIFICATION; CONFORMATIONAL TRANSITION; DRUG SYNTHESIS; NONHUMAN; RNA SYNTHESIS; SOLID PHASE EXTRACTION;

EID: 0032473810     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00157-9     Document Type: Article

References (19)

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14. - in THF was employed. Compound 2a was also stable towards treatment with a slightly basic solution of N,N-diethyldithiocarbamate sodium salt (ddtc), pH 9.5, which is required for removal of Pd contamination.
15. - calc. 887.4, found 887.7.
16. - calc. 929.4, found 929.5.
17. 17. McMinn, D. L.; Greenberg, M. M. Tetrahedron 1996, 52, 3827-3840.
18. 18. The uridine ally1 phosphoramidite was synthesized in a similar manner as the cytidine phosphoramidites.
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