Overexpression of a minor component of myelin basic protein isoform (17.2kDa) can restore myelinogenesis in transgenic shiverer mice

Brain Research

Volumn 785, Issue 2, 1998, Pages 245-252

  Kimura, Minoru ^a   Sato, Masahiro ^a   Akatsuka, Akira ^a   Saito, Shigeharu ^a   Ando, Kiyoshi ^a   Yokoyama, Minesuke ^b   Katsuki, Motoya ^a  

^a TOKAI UNIVERSITY   (Japan)

^b CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

Author keywords

Central nervous system; Gene therapy; Myelin basic protein; Myelinogenesis; Shiverer; Transgenic mouse

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; MYELIN BASIC PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; GENE THERAPY; MOUSE; MYELIN DEFICIENCY; MYELINATION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ALTERNATIVE SPLICING; ANIMALS; BRAIN; CEREBELLUM; FEMALE; FERTILIZATION IN VITRO; GLOBINS; HOMOZYGOTE; MALE; MICE; MICE, NEUROLOGIC MUTANTS; MICE, TRANSGENIC; MOLECULAR WEIGHT; MYELIN BASIC PROTEINS; OOCYTES; ORGAN SPECIFICITY; PHENOTYPE; RABBITS; RNA, MESSENGER; SPERMATOZOA; SUPEROVULATION;

EID: 0032473585     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01383-8     Document Type: Article

References (39)

1. Allinquant B., Staugaitis S.M., D'Urso D., Colman D.R. The ectopic expression of myelin basic protein isoforms in shiverer oligodendrocytes: Implications for myelinogenesis. J. Cell Biol. 113:1991;393-403.
2. Aruga J., Okano H., Mikoshiba M. Identification of the new isoforms of myelin basic protein: The existence of exon 5a. J. Neurochem. 56:1991;1222-1226.
3. Barbarese E., Carson J.H., Braun P.E. Accumulation of the four myelin basic proteins in mouse brain during development. J. Neurochem. 31:1978;779-782.
4. Bird T.D., Farrel D.F., Sumo S.M. Brain lipid composition of the shiverer mouse: Genetic defect in myelin development. J. Neurochem. 31:1978;387-391.
5. Blin N., Stafford D.W. A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res. 3:1976;2303-2308.
6. Brophy P.J., Boccaccio G.L., Colman D.R. The distribution of myelin basic protein mRNAs within myelinating oligodendrocytes. Trends Neurosci. 16:1993;515-521.
7. Campagnoni A.T., Pribyl T.M., Campagnoni C.W., Kampf K., Amur-Umarjee S., Landry C.F., Handley V.W., Newman S.L., Garbay B., Kitamura K. Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain. J. Biol. Chem. 268:1993;4930-4938.
8. Chernoff G.F. Shiverer: An autosomal recessive mutant mouse with myelin deficiency. J. Hered. 72:1981;128.
9. Chirgwin J.M., Przybyla A.E., MacDonald R.J., Rutter W.J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:1979;5294-5299.
10. de Ferra F., Engh H., Hudson L., Kamholz J., Puckett C., Molineaux S., Lazzarini R.A. Alternative splicing accounts for the four forms of myelin basic protein. Cell. 43:1985;721-727.
11. Fritz R.B., Zhao M.-L. Encephalitogenicity of myelin basic protein exon-2 peptide in mice. J. Neuroimmunol. 51:1994;1-6.
12. M. Katsuki, T. Nomura, Experimental Manual for Developmental Engineering: A Method of Transgenic Mouse Production, Kohdansha, Tokyo, 1987 (in Japanese).
13. Katsuki M., Sato M., Kimura M., Yokoyama M., Kobayashi K., Nomura T. Conversion of normal behavior to shiverer by myelin basic protein antisense cDNA in transgenic mice. Science. 241:1988;593-595.
14. Kimura M., Inoko H., Katsuki M., Ando A., Sato T., Takashima H., Inayama S., Okano H., Takamatsu K., Mikoshiba K., Tsukada Y., Watanabe I. Molecular genetic analysis of myelin-deficient mice: Shiverer mutant mice show deletion in gene(s) coding for myelin basic protein. J. Neurochem. 44:1985;692-696.
15. Kimura M., Sato M., Akatsuka A., Nozawa-Kimura S., Takahashi R., Yokoyama M., Nomura T., Katsuki M. Restoration of myelin formation by s single type of myelin basic protein in transgenic shiverer mice. Proc. Natl. Acad. Sci. U.S.A. 86:1989;5661-5665.
16. Kitamura K., Newman S.L., Campagnoni C.W., Verdi J.M., Mohandas T., Handley V.W., Campagnoni A.T. Expression of a novel transcript of myelin basic protein gene. J. Neurochem. 54:1990;2032-2041.
17. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
18. M.B. Lees, S.W. Brostoff, Proteins of myelin, in: P. Morell (Ed.), Myelin, 2nd edn., Plenum, New York, 1984, pp. 197-224.
19. Mathisen P.M., Pease S., Garvey J., Hood L., Readhead C. Identification of an embryonic isoform of myelin basic protein that is expressed widely in the mouse embryo. Proc. Natl. Acad. Sci. U.S.A. 90:1993;10125-10129.
20. Mikoshiba K., Okano H., Inoue Y., Fujishiro M., Takamatsu K., Lachapelle F., Baumann N., Tsukada Y. Immunohistochemical, biochemical and electron microscopic analysis of myelin formation in the central nervous system of myelin deficient (mld) mutant mice. Dev. Brain Res. 35:1987;111-121.
21. Newman S., Kitamura K., Campagnoni A.T. Identification of a cDNA coding for a fifth form of myelin basic protein in mouse. Proc. Natl. Acad. Sci. U.S.A. 84:1987;886-890.
22. Omlin F.X., de F. Webster H., Palkovits C.G., Cohen S.R. Immunocytochemical localization of basic protein in major dense line regions of central and peripheral myelin. J. Cell Biol. 95:1982;242-248.
23. Popko B., Puckett C., Lai E., Shine H.D., Readhead C., Takahashi N., Hunt S.W. III, Sidman R.L., Hood L. Myelin deficient mice: Expression of myelin basic protein and generation of mice with varying levels of myelin. Cell. 48:1987;713-721.
24. Privat A., Jacque C., Bourre J.M., Dupouey P., Baumann M. Absence of the major dense line in myelin of the mutant mouse 'shiverer'. Neurosci. Lett. 12:1979;107-112.
25. Readhead C., Popko B., Takahashi N., Shine H.D., Saavedra R.A., Sidman R.L., Hood L. Expression of a myelin basic protein gene in transgenic shiverer mice: Correction of the dysmyelinating phenotype. Cell. 48:1987;703-712.
26. Roach A., Boylan K., Horvath S., Prusiner S.B., Hood L.E. Characterization of cloned cDNA representing rat myelin basic protein: Absence of expression in brain of shiverer mutant mouse. Cell. 34:1983;799-806.
27. Roach A., Takahashi N., Pravtcheva D., Ruddle F., Hood L. Chromosomal mapping of mouse myelin basic protein gene and structure and transcription of the partially deleted gene in shiverer mutant mice. Cell. 42:1985;149-155.
28. Segal B.M., Raine C.S., McFarlin D.E., Voskuhl R.R., McFarland H.F. Experimental allergic encephalomyelitis induced by the peptide encoded by exon 2 of the MBP gene, a peptide implicated in remyelination. J. Neuroimmunol. 51:1994;7-19.
29. mld) mutant allele: Morphological comparison with shiverer (shi) allele on a B6C3 mouse stock. Brain Res. 360:1985;235-247.
30. Shine H.D., Readhead C., Popko B., Hood L., Sidman R.L. Morphometric analysis of normal, mutant, and transgenic CNS: Correlation of myelin basic protein expression to myelinogenesis. J. Neurochem. 58:1992;342-349.
31. Smith R. Self-association of myelin basic protein: Enhancement by detergents and lipids. Biochemistry. 21:1982;2697-2701.
32. Smith R., McDonald B.J. Association of myelin basic protein with detergent micelles. Biochim. Biophys. Acta. 554:1979;133-147.
33. Staugaitis S.M., Smith P.R., Colman D.R. Expression of myelin basic protein isoforms in nonglial cells. J. Cell Biol. 110:1990;1719-1727.
34. Takahashi N., Roach A., Teplow D.B., Prusiner S.B., Hood L. Cloning and characterization of the myelin basic protein gene from mouse: One gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons. Cell. 42:1985;139-148.
35. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. U.S.A. 76:1979;4350-4354.
36. Toyoda Y., Yokoyama M., Hoshi T. Studies on the fertilization of mouse eggs in vitro: I. In vitro fertilization of eggs by fresh epididymal sperm. Jpn. J. Anim. Reprod. 16:1971;147-151. (in Japanese).
37. Turnley A.M., Morahan G., Okano H., Bernard O., Mikoshiba K., Allison J., Bartlett P.F., Miller J.F.A.P. Dysmyelination in transgenic mice resulting from expression of class I histocompatibility molecules in oligodendrocytes. Nature. 353:1991;566-569.
38. Ueno S., Kotani Y., Kondoh K., Sano A., Kakimoto Y., Campagnoni A.T. The 3′-untranslated region of mouse myelin basic protein gene increases the amount of mRNA in immortalized mouse oligodendrocytes. Biochem. Biophys. Res. Commun. 204:1994;1352-1357.
39. Yoshioka T., Feigenbaum L., Jay G. Transgenic mouse model for central nervous system demyelination. Mol. Cell. Biol. 11:1991;5479-5486.