Assaying extrachromosomal gene therapy vectors that carry replication/persistence elements

Advanced Drug Delivery Reviews

Volumn 30, Issue 1-3, 1998, Pages 13-21

  Sclimenti, Christopher R ^a   Calos, Michele P ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dividing cells; Epstein Barr virus; Family of repeats; Nuclear retention; Origin of replication; Vector longevity

Indexed keywords

BIOASSAY; BIOSYNTHESIS; CELLS; CYTOLOGY; DNA; GENETIC ENGINEERING; TISSUE CULTURE; VIRUSES;

DIVIDING CELLS; EPSTEIN-BARR VIRUS; EXTRACHROMOSOMAL GENE THERAPY; NUCLEAR RETENTION; REPLICATION; VECTOR LONGEVITY;

DRUG THERAPY;

PLASMID VECTOR;

ANIMAL CELL; CELL DIVISION; DNA REPLICATION; DRUG DELIVERY SYSTEM; EPSTEIN BARR VIRUS; EXPRESSION VECTOR; GENE EXPRESSION; GENE EXPRESSION SYSTEM; GENE THERAPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; VIRUS GENOME;

EID: 0032473565     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(97)00103-8     Document Type: Review

References (13)

1. Calos M.P. The potential of extrachromosomal replicating vectors for gene therapy. Trends Genet. 12:1996;463-466.
2. Wohlgemuth J.G., Kang S.H., Bulboaca G.H., Nawotka K.A., Calos M.P. Long-term gene expression from autonomously replicating vectors in mammalian cells. Gene Ther. 3:1996;503-512.
3. Krysan P.J., Haase S.B., Calos M.P. Isolation of human sequences that replicate autonomously in human cells. Mol. Cell. Biol. 9:1989;1026-1033.
4. Krysan P.J., Calos M.P. Replication initiates at multiple locations on an autonomously replicating plasmid in human cells. Mol. Cell. Biol. 11:1991;1464-1472.
5. Rawlins D.R., Milman G., Hayward D., Hayward GS. Sequence-specific DNA binding of the Epstein-Barr nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance region. Cell. 42:1985;859-868.
6. Harris A., Young B.D., Griffin B.E. Random association of Epstein-Barr virus genomes with host cell metaphase chromosomes in Burkitt's lymphoma-derived cell lines. J. Virol. 56:1985;328-332.
7. Jankelevich S., Kolman J.L., Bodnar J.W., Miller G. A nuclear matrix attachment region organizes the Epstein-Barr viral plasmid in Raji cells into a single DNA domain. EMBO J. 11:1992;1165-1176.
8. Haase S.B., Calos M.P. Replication control of autonomously replicating sequences. Nucleic Acids Res. 19:1991;5053-5058.
9. Yates J., Warren N., Reisman D., Sugden B. A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells. Proc. Natl. Acad. Sci. USA. 81:1984;3806-3810.
10. Lusky M., Botchan M. Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences. Nature (London). 293:1981;79-81.
11. Hirt B. Selective extraction of polyoma DNA from infected mouse cultures. J. Mol. Biol. 26:1967;365-369.
12. Feinberg A.P., Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:1983;6-13.
13. Wolff J.A., Malone R.W., Williams P., Chang W., Acsadi G., Jani A., Felgner P.L. Direct gene transfer into mouse muscle in vivo. Science. 247:1990;1465-1468.