Hydrogels of poly(ethylene glycol): Mechanical characterization and release of a model drug

Journal of Controlled Release

Volumn 52, Issue 1-2, 1998, Pages 41-51

  Iza, M ^a   Stoianovici, G ^a   Viora, L ^a   Grossiord, J L ^a   Couarraze, G ^a  

^a UNIV PARIS SUD   (France)

Author keywords

Acebutolol chlorhydrate; Diffusion; Poly(ethylene glycol); Scaling laws; Thermosensitive hydrogels

Indexed keywords

ACEBUTOLOL; CHLORIDE; HEXAMETHYLENE DIISOCYANATE; MACROGOL;

ARTICLE; CROSS LINKING; DIFFUSION; DRUG SOLUBILITY; HEAT SENSITIVITY; HYDROGEL; PRIORITY JOURNAL; STOICHIOMETRY;

ACEBUTOLOL; DIFFUSION; HYDROGEL; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; TEMPERATURE;

EID: 0032473522     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(97)00191-0     Document Type: Article

References (23)

1. Gutowska A., Bae Y.H., Jacobs H., Feijen J., Kim S.W. Thermosensitive interpenetrating polymer networks: synthesis, characterization, and macromolecular release. Macromolecules. 27:1994;4167-4175.
2. Bae Y.H., Okano T., Kim S.W. 'On-off' thermocontrol of solute transport. I. temperature dependence of swelling of N-isopropylacrylamide networks modified with hydrophobic components in water. Pharm. Res. 8:1991;531-537.
3. L.C. Dong, A.S. Hoffman, Thermally reversible hydrogels, in: R.M. Ottenbrite, S.J. Huang, K. Park, (Eds.), Hydrogels and Biodegradable Polymers for Bioapplications, ACS Symposium series 627, Washington DC, 1996, pp. 236-244.
4. Gnanou Y., Hild G., Rempp P. Hydrophilic polyurethane networks based on poly(ethylene oxide): synthesis, characterization and properties. Potential applications as biomaterials. Macromolecules. 17:1984;945-952.
5. N.B. Graham, Poly(ethylene oxide) and related hydrogels, in: N.A. Peppas (Ed.), Hydrogels in Medicine and Pharmacy, vol. II, CRC Press, 1986, pp. 95-113.
6. Kim S.W., Bae Y.H., Okano T. Hydrogels: swelling, drug loading, and release. Pharm. Res. 9:1992;283-290.
7. O. Hirasa, S. Ito, A. Yamauchi, Thermoresponsive polymer hydrogel, in: D. De Rossi, K. Kajiwara, Y. Osada, A.Yamauchi (Eds.), Polymer Gels, Plenum Press, New York, 1991, pp. 247-256.
8. Reinhart C.T., Korsmeyer R.W., Peppas N.A. Macromolecular network structure and its effects on drug and protein diffusion. Int. J. Pharm. Tech. Prod. Mfr. 2:1981;9-16.
9. Peppas N.A., Ségot-Chicq S. Les dispositifs à libération contrôlée pour la délivrance des principes actifs médicamenteux. II. Aspects fondamentaux de la diffusion des principes actifs dans les polymères. Stp Pharma. 1:1985;121-127.
10. Graham N.B., McNeill M.E. Morphology of poly(ethylene oxide)-based hydrogels in relation to controlled drug delivery. Makromol. Chem. Macromol. Symp. 19:1988;255-273.
11. Graham N.B., McNeill M.E. Hydrogels for controlled drug delivery. Biomaterials. 5:1984;27-36.
12. Merrill E.W., Dennison K.A., Sung C. Partitioning and diffusion of solutes in hydrogels of poly(ethylene oxide). Biomaterials. 14:1993;1117-1126.
13. M.P. Embrey and N.B. Graham, Controlled release compositions, U.K. Patent 2,047,093 A, Nov 26, 1980.
14. Waters N.E. The indentation of thin rubber sheets by spherical indentors. Br. J. Appl. Phys. 16:1965;557-563.
15. P.J. Flory, Principles of Polymer Chemistry, Cornell University Press, Ithaca, NY, 1978.
16. Peppas N.A. Analysis of fickian and non-fickian drug release from polymers. Pharm. Acta Helv. 60:1985;110-111.
17. Gnanou Y., Hild G., Bastide J., Rempp P. Hydrophilic polyurethane networks exhibiting anisotropic swelling behaviour. J. Polym. Mater. 4:1987;123-130.
18. Graham N.B., Zulfiqar M. Interaction of poly(ethylene oxide) with solvents: 3. Synthesis and swelling in water of crosslinked poly(ethylene glycol) urethane networks. Polymer. 30:1989;2130-2135.
19. Graham N.B., Chen C.F. Interaction of poly(ethylene oxide) with solvent: 5. The densities of water/Poly(ethylene glycol) mixtures. Eur. Polym. J. 29:1993;149-151.
20. de Vringer T., Joosten J.G.H., Junginger H.E. A study of the hydration of polyoxyethylene at low temperatures by differential scanning calorimetry. Colloid Polymer Sci. 264:1986;623-630.
21. K.P. Antonsen, A.S. Hoffman, Water structure of PEG solutions by differential scanning calorimetry measurements, in: J. Milton Harris (Ed.), Poly(Ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications, Plenum Press, New York, 1992, pp. 15-28.
22. P.G. De Gennes, Scaling Concepts in Polymer Physics, Cornell University Press, Ithaca, NY, 1979.
23. Hild G., Okasha R., Macret M., Gnanou Y. Relationship between elastic modulus and volume swelling degree of polymer networks swollen to equilibrium in good diluents, 4: Interpretation of experimental results on the basis of scaling concepts. Makromol. Chem. 187:1986;2271-2288.