Cerebral N-acetylaspartate is low in patients with multiple sclerosis and abnormal visual evoked potentials

American Journal of Neuroradiology

Volumn 19, Issue 6, 1998, Pages 1047-1054

  Heide, A C ^a   Kraft, G H ^b   Slimp, J C ^b   Gardner, J C ^a   Posse, S ^c   Serafini, S ^a   Bowen, J D ^a   Richards, T L ^a,d  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c FORSCHUNGSZENTRUM JÜLICH   (Germany)

^d UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N ACETYLASPARTIC ACID;

ARTICLE; BRAIN REGION; CLINICAL ARTICLE; DIAGNOSTIC IMAGING; EVOKED VISUAL RESPONSE; HUMAN; MULTIPLE SCLEROSIS; SPECTROMETRY;

ADULT; ASPARTIC ACID; BRAIN MAPPING; CHOLINE; CREATINE; DISABILITY EVALUATION; ECHO-PLANAR IMAGING; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS, VISUAL; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MULTIPLE SCLEROSIS; NEUROLOGIC EXAMINATION; NEUROMYELITIS OPTICA; OCCIPITAL LOBE; SIGNAL PROCESSING, COMPUTER-ASSISTED; VISUAL PATHWAYS;

EID: 0032471919     PISSN: 01956108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Paty DW. Multiple sclerosis with an emphasis on MR imaging. Curr Neurol 1991;11:169-198
2. Brusa A, Mortimer C, Jones SJ. Clinical evaluation of VEPs to inter-leaved checkerboard reversal stimulation of central, hemi- and peripheral fields. Electroencephalogr Clin Neurophysiol 1995;96:485-494
3. Bodis-Wollner I. Sensory evoked potentials: PERG, VEP, and SEP. Curr Opin Neurol Neurosurg 1992;5:716-726
4. Brasil-Neto JP. Evoked potentials in multiple sclerosis: recent experience at the Locomotor System Diseases Hospital. Arq Neuropsiquiatr 1991;49:204-207
5. Fulgente T, Thomas A, Lobefalo L, et al. Are VEP abnormalities in optic neuritis (ON) dependent on plaque size? A reappraisal of the physiopathology of ON based on improved MRI and multiple-lead recordings. Ital J Neurol Sci 1996;17:43-54
6. Jones SJ. Visual evoked potentials after optic neuritis: effect of time interval, age and disease dissemination. J Neurol 1993;240:489-494
7. van Diemen HA, Lanting P, Koetsier JC, Strijers RL, van WHK, Polman CH. Evaluation of the visual system in multiple sclerosis: a comparative study of diagnostic tests. Clin Neurol Neurosurg 1992;94:191-195
8. Arnold DL, Matthews PM, Francis G, Antel J. Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease. Magn Reson Med 1990;14:154-159
9. Matthews PM, Francis G, Antel J, Arnold DL. Proton magnetic resonance spectroscopy for metabolic characterization of plaques in multiple sclerosis [published erratum appears in Neurology 1991;41:1828]. Neurology 1991;41:1251-1256
10. Narayana PA, Wolinsky JS, Jackson EF, McCarthy M. Proton MR spectroscopy of gadolinium-enhanced multiple sclerosis plaques. J Magn Reson Imaging 1992;2:263-270
11. Miller DH, Austin SJ, Connelly A, Youl BD, Gadian DG, McDonald WI. Proton magnetic resonance spectroscopy of an acute and chronic lesion in multiple sclerosis. Lancet 1991;337:58-59
12. van Hecke P, Marchai G, Johannik K, et al. Human brain proton localized NMR spectroscopy in multiple sclerosis. Magn Reson Med 1991;18:199-206
13. Grossman RI, Lenkinski RE, Ramer KN, Gonzalez SF, Cohen JA. MR proton spectroscopy in multiple sclerosis. AJNR Am J Neuroradiol 1992;13:1535-1543
14. Weinstein GW, Odom JV, Cavender S. Visually evoked potentials and electroretinography in neurologic evaluation. Neurol Clin 1991; 9:225-242
15. Poser C, Paty D, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983;1983:227-231
16. Peters AR, Geelen JAG, denBoer JA, Prevo RL, Minderhoud JM, Gravenmade EJ. A study of multiple sclerosis patients with magnetic resonance spectroscopic imaging. Multiple Sclerosis 1995;1:25-31
17. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444-1452
18. Lewine JD, Orrison WW. Clinical electroencephalography and event-related potentials. In: Orrison WW, Lewine JD, Sanders JA, Hartshorne MF. eds. Functional Brain Imaging. St Louis: Mosby; 1995:327-368
19. Jasper HH. Report of the committee on methods of clinical examination in EEG. Appendix: the ten-twenty electrode system of the International Federation. Electroencephalogr Clin Neurophysiol 1958;10:371-375
20. Hayes CE, Mathis CM. Improved brain coil for fMRI and high resolution imaging. In: Proceedings of the Fourth Annual Meeting of the Society of Magnetic Resonance. Society of Magnetic Resonance, Berkeley, CA; 1996:1414
21. Posse S, DeCarli C, LeBihan D. Three-dimensional echo-planar MR spectroscopic imaging at short echo times in the human brain. Radiology 1994;192:733-738
22. Posse S, Tedeschi G, Risinger R, Ogg R, Le BD. High speed 1H spectroscopic imaging in human brain by echo planar spatial-spectral encoding. Magn Reson Med 1995;33:34-40
23. Posse S, Dager SR, Richards TL, et al. In vivo measurement of regional brain metabolic response to hyperventilation using magnetic resonance proton echo planar spectroscopic imaging (PEPSI). Magn Reson Med 1997;37:858-865
24. Ostuni JL, Levin RL, Frank JA, DeCarli C. Correspondence of closest gradient voxels: a robust registration algorithm. J Magn Reson Imaging 1997;7:410-415
25. Zar JH. Biostatistical Analysis. Englewood Cliffs, NJ: Prentice-Hall; 1984:162-205
26. Birken DL, Oldendorf WH. N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev 1989;13:23-31
27. Gill SS, Small RK, Thomas DGT, et al. Brain metabolites as 1H NMR markers of neuronal and glial disorders. NMR Biomed 1989; 2:196-200
28. Bruhn H, Frahm J, Gyngell ML, Merboldt KD, Hanicke W, Sauter R. Cerebral metabolism in man after acute stroke: new observations using localized proton NMR spectroscopy. Magn Reson Med 1989;9:126-131
29. Waxman SG, Ritchie JM. Molecular dissection of the myelinated mon. Ann Neurol 1993;33:121-136
30. Huszak I. Biochemical aspects of multiple sclerosis. In: Lajtha A, ed. Handbook of Neurochemistry, VII: pathological chemistry of the nervous system. New York: Plenum Press; 1972:47-91
31. Filippi M, Campi A, Mammi S, et al. Brain magnetic resonance imaging and multimodal evoked potentials in benign and secondary progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 1995;58:31-37
32. Levine RA, Gardner JC, Stufflebeam SM, et al. Binaural auditory processing in multiple sclerosis subjects. Hear Res 1993;68:59-72
33. Levine RA, Gardner JC, Fullerton BC, et al. Effects of multiple sclerosis brainstem lesions on sound lateralization and brainstem auditory evoked potentials. Hear Res 1993;68:73-88