Insulin Unexpectedly Increases The Glucose 6-Phosphate KAOf Skeletal Muscle Glycogen Synthase In Calorie-Restricted Monkeys

Journal of Basic and Clinical Physiology and Pharmacology

Volumn 9, Issue 2-4, 1998, Pages 309-324

  Ortmeyer, Heidi K ^a   Hansen, Barbara C ^a   Huang, Laura ^b   Larner, Joseph ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

cAMP dependent protein kinase; protein phosphatase 1 2A; protein phosphatase 2C

Indexed keywords

GLUCOSE 6 PHOSPHATE; GLYCOGEN SYNTHASE; INSULIN;

ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CALORIC RESTRICTION; CONTROLLED STUDY; CORRELATION FUNCTION; ENZYME ACTIVITY; GLUCOSE UTILIZATION; HORMONE ACTION; MUSCLE METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PHOSPHORYLATION; RHESUS MONKEY; TISSUE LEVEL;

ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIABETES MELLITUS, TYPE 2; ENERGY INTAKE; GLUCOSE-6-PHOSPHATE; GLYCOGEN SYNTHASE; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; INSULIN; MACACA MULATTA; MUSCLE, SKELETAL;

EID: 0032470013     PISSN: 07926855     EISSN: 21910286     Source Type: Journal    
DOI: 10.1515/JBCPP.1998.9.2-4.309     Document Type: Article

References (12)

1. Hansen, BC, Bodkin, NL. Primary prevention of diabetes mellitus by prevention of obesity' in monkeys. Diabetes 1993; 42: 1809–1814.
2. Bodkin, NL, Ortmeyer, HK, Hansen, BC. Long-term dietary restriction in older-aged rhesus monkeys: effects on insulin resistance. J Gerontol: Biol Sci 1995; 50A: B142-B147.
3. Ortmeyer, HK, Bodkin, NL, Hansen, BC. Chronic caloric restriction alters glycogen metabolism in rhesus monkeys. Obes Res 1994; 2: 549–555.
4. Ortmeyer, HK, Bodkin, NL, Hansen, BC. Relationship of skeletal muscle glucose-6-phosphate to glucose disposal rate and glycogen synthase activity in insulin-resistant and non-insulin-dependent diabetic rhesus monkeys. Diabetologia 1994; 37: 127–133:
5. Ortmeyer, HK, Bodkin, NL, Varghese, SS, Hansen, BC. Glycogen phosphorylase activity and glycogen concentration in muscle of normal to overtly diabetic rhesus monkeys. Int J Obes 1996; 20: 98–105.
6. Ortmeyer, HK, Bodkin, NL, Hansen, BC. Insulin-mediated glycogen synthase activity in muscle of spontaneously insulin-resistant and diabetic rhesus monkeys. Am J Physiol 1993; 265: R552-R558.
7. Ortmeyer, H, Bodkin, N. Lack of defect in insulin action on hepatic glycogen synthase and phosphorylase in insulin-resistant monkeys. Am J Physiol 1998; 274: G1005-G1010.
8. Roach, P, Lamer, J. Rabbit skeletal muscle glycogen synthase II. Enzyme phosphorylation state and effector concentrations as interacting control parameters. J Biol Chem 1976; 251: 1920–1925.
9. Henderson, P. Statistical analysis of enzyme kinetic data. In: Eisenthal R, Danson M, eds. Enzyme Assays: A Practical Approach. Oxford: IRL Press, 1993; 277–316.
10. Ortmeyer, H. Relationship of glycogen synthase and glycogen phosphorylase to protein phosphatase 2C and cAMP-dependent protein kinase in liver of obese rhesus monkeys. Obes Res 1997; 5: 613–621.
11. Cohen, P. Muscle glycogen synthase. In: Boyer P, Krebs E, eds. The Enzymes. Orlando: Academic Press, 1986; 461–497.
12. Ortmeyer, H. Insulin decreases skeletal muscle cAMP-dependent protein kinase (PKA) activity in normal monkeys and increases PKA activity in insulin-resistant monkeys. J Basic Clin Physiol Pharmacol 1997; 8: 223–235.