Low-dose flunarizine does not affect short-term fetal circulatory responses to acute asphyxia in sheep near term

Reproduction, Fertility and Development

Volumn 10, Issue 5, 1998, Pages 405-411

  Garnier, Yves ^a   Berger, Richard ^a   Pfeiffer, Doris ^a   Jensen, Arne ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Fetal sheep; Flunarizine; Intrauterine asphyxia; Organ blood flow

Indexed keywords

ADRENALIN; CALCIUM ANTAGONIST; CATECHOLAMINE; DOPAMINE; FLUNARIZINE; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR RESPONSE; CATECHOLAMINE BLOOD LEVEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; FETUS; FETUS CIRCULATION; FETUS HYPOXIA; GESTATIONAL AGE; NONHUMAN; ORGAN BLOOD FLOW; SHEEP;

ADRENAL GLANDS; ANIMALS; ASPHYXIA; BLOOD GAS ANALYSIS; BLOOD GLUCOSE; BLOOD PRESSURE; BRAIN; CALCIUM CHANNEL BLOCKERS; CARDIOVASCULAR SYSTEM; CATECHOLAMINES; FEMALE; FETUS; FLUNARIZINE; HEART RATE, FETAL; LUNG; PLACENTA; PREGNANCY; REGIONAL BLOOD FLOW; SHEEP; VENTRICULAR FUNCTION;

ANIMALIA; OVIS ARIES;

EID: 0032469570     PISSN: 10313613     EISSN: None     Source Type: Journal    
DOI: 10.1071/RD97081     Document Type: Article

References (22)

1. Berger, R., Lehmann, T., Karcher, J., Schachenmayr, W. and Jensen, A. (1996). Relation between cerebral oxygen delivery and neuronal cell damage in fetal sheep near term. Reprod. Fertil. Dev. 8, 317-21.
2. Berger, R., Lehmann, T., Karcher, J., Garnier, Y. and Jensen, A. (1998). Low dose flunarizine protects the fetal brain from ischemic injury in sheep. Pediatr. Res. 44, 277-82.
3. Chumas, P. D., Del Bigio, M. R., Drake, J. M. and Tuor, U. I. (1993). A comparison of the protective effect of dexamethasone to other potential prophylactic agents in a neonatal rat model of cerebral hypoxia-ischemia. J. Neurosurg. 79, 414-20.
4. de Haan, H. H., Van Reempts, J. L. H., Borgers, M., de Haan, J., Vles, J. S. H. and Hasaart, T. H. M. (1993). Possible neuroprotective properties of flunarizine infused after asphyxia in fetal lambs are not explained by effects on cerebral blood flow or systemic blood pressure. Pediatr. Res. 34, 379-84
5. Edmonds, H. L. Jr, Wauquier, A., Melis, W., van den Broeck, W. A. E., van Loon, J. and Janssen, P. A. J. (1985). Improved short-term neurological recovery with flunarizine in a canine model of cardiac arrest. Am. J. Emerg. Med. 3, 150-5.
6. Edvinsson, L. and Mackenzie, E. T. (1977). Amine mechanisms in the cerebral circulation. Pharmacol. Rev. 28, 275-348.
7. Gunn, A. J., Williams, C. E., Bennet, L., Cook, C. J. and Gluckman, P. D. (1988). Perinatal cerebral asphyxia: pharmacological intervention. Fetal Ther. 3, 98-107.
8. Gunn, A. J., Mydlar, T., Bennet, L., Faull, R. L. M., Gorter, S., Cook, C., Johnston, B. M. and Gluckman, P. D. (1989). The neuroprotective actions of a calcium channel antagonist, flunarizine, in the infant rat. Pediatr. Res. 25, 573-6.
9. Gunn, A. J., Williams, C. E., Mallard, E. C., Tan, W. K. M. and Gluckman, P. D. (1994). Flunarizine, a calcium channel antagonist, is partially prophylactically neuroprotective in hypoxic-ischemic encephalopathy in the fetal sheep. Pediatr. Res. 35, 657-63.
10. Heymann, M. A., Payne, B. D., Hoffman, J. I. E. and Rudolph, A. M. (1977). Blood flow measurements with radionuclide-labeled particles. Prog. Cardiovasc. Dis. 20, 55-79.
11. Jelinek, J. and Jensen, A. (1991). Catecholamine concentrations in plasma and organs of the fetal guinea pig during normoxaemia, hypoxaemia and asphyxia. J. Dev. Physiol. 15, 145-52.
12. Jensen, A. and Berger, R. (1991). Fetal circulatory responses to oxygen lack. J. Dev. Physiol. 16, 181-207.
13. Jensen, A., Hohmann, M. and Künzel, W. (1987). Dynamic changes in organ blood flow and oxygen consumption during acute asphyxia in fetal sheep. J. Dev. Physiol. 9, 543-59.
14. Jensen, A., Roman, Ch. and Rudolph, A. M. (1991). Effects of reducing uterine blood flow on foetal blood flow distribution and oxygen delivery. J. Dev. Physiol. 15, 309-23.
15. Krieglstein, J. (1988). 'Pharmacology of Cerebral Ischemia'. (Wissenschaftliche Verlagsgesellschaft: Stuttgart, Germany.)
16. Krieglstein, J. and Oberpichler-Schwenk, H. (1994). 'Pharmacology of Cerebral Ischemia'. (Medpharm Scientific Publishers: Stuttgart, Germany.)
17. Rudolph, A. M. and Heymann, M. A. (1967). Circulation of the fetus in utero: Methods for studying distribution of blood flow, cardiac output and organ blood flow. Circ. Res. 21, 163-84.
18. Silverstein, F. S., Buchanan, K., Hudson, C. and Johnston, M. V. (1986). Flunarizine limits hypoxia-ischemia induced morphologic injury in immature rat brain. Stroke 17, 477-82.
19. Tegtmeier, F., Dengler, K., Zacharias, E., Eichhorn, R. and Höller, M. (1987). 'Brain concentrations and effect of cerebroprotective drugs: investigations with flunarizine and R 56865.' (Preclinical Research Report, Janssen Research Foundation.)
20. Todd, P. A. and Benfield, P. (1989). Flunarizine: A reappraisal of its pharmacological properties and therapeutic use in neurological disorders. Drugs 38, 481-99.
21. Van Reempts, J., Borgers, M., Van Dael, L., van Eyndhoven, J. and Van de Ven, M. (1993). Protection with flunarizine against hypoxic-ischemic damage of the rat cerebral cortex. A quantitative morphologic assessment. Arch. Int. Pharmacodyn. Ther. 232, 76-88.
22. Volpe, J. J. (1995). 'Neurology of the Newborn'. (WB Saunders: Philadelphia.)