Improving the binding affinity of an antibody using molecular modeling and site-directed mutagenesis

Protein Science

Volumn 7, Issue 8, 1998, Pages 1671-1680

  Casipit, Clayton L ^a,b   Tal, Rony ^a   Wittman, Vaughan ^a   Chavaillaz, Pierre André ^a   Arbuthnott, Kathy ^a   Weidanz, Jon A ^a   Jiao, Jin A N ^a   Wong, Hing C ^a  

^a Sunol Molecular Corporation   (United States)

^b Entelos Inc   (United States)

Author keywords

Affinity improvement; Computer modeling; Peptide antibody complex; Site directed mutagenesis

Indexed keywords

ALANINE; ARGININE; ASPARTIC ACID; GLUTAMIC ACID; GLYCINE; ISOLEUCINE; PHENYLALANINE; SERINE; TYROSINE;

AMINO ACID SUBSTITUTION; ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ANTIBODY STRUCTURE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; BACILLUS LICHENIFORMIS; COMPLEX FORMATION; COMPUTER MODEL; COMPUTER PROGRAM; GENETIC ENGINEERING; HYDROGEN BOND; IMMUNOASSAY; MOLECULAR MODEL; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

EID: 0032469296     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560070802     Document Type: Article

References (7)

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