Tyrosine phosphorylated proteins in synovial cells of rheumatoid arthritis

International Reviews of Immunology

Volumn 17, Issue 5-6, 1998, Pages 365-382

  Takeuchi, Tsutomu ^a   Abe, Tohru ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Adhesion molecules; FAK; Integrins; Signal transduction; Tyrosine kinase

Indexed keywords

EID: 0032468491     PISSN: 08830185     EISSN: None     Source Type: Journal    
DOI: 10.3109/08830189809054411     Document Type: Article

References (69)

1. Harris, E.D., Jr., Rheumatoid arthritis, Pathophysiology and implications for therapy N. Engl. J. Med. 322, 1277-1289, 1990.
2. Panayi, G.S. The pathogenesis of rheumatoid arthritis: from molecules to the whole patient. Br. J. Rheumatol. 32, 533-536, 1993.
3. Sewell, K.L. and Trentham, D.E. Pathogenesis of rheumatoid arthritis. Lancet 341, 283-286, 1993.
4. Feldmann, M., Brennan, F.M., and Maini, R.N, Rheumatoid Arthritis. Cell 85, 307-310, 1996.
5. Gay, S., Gay, R.E., and Koopman, W.J. Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis. two cellular mechanisms explain joint destruction? Ann. Rheum. Dis. 52 Suppl. 1, S39-47, 1993.
6. Lipsky, P.E. Immunopathogenesis and treatment of rheumatoid arthritis. J. Rheumatal. Suppl 32, 92-94, 1992.
7. Elliott, M.J. and Maini, R.N. New directions for biological therapy in rheumatoid arthritis. Int. Arch. Allergy. Immunol. 104, 112-125, 1994.
8. Kavanaugh, A.F., Davis, L.S., Nichols, L.A., Norris, S.H., Rothlein, R., Scharschmidt, L.A., and Lipsky, P.E. Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule I. Arthritis Rheum. 37, 992-999, 1994.
9. Fox, D. A. Biological therapies: a novel approach to the treatment of autoimmune disease. Am. J. Med. 99, 82-88, 1995.
10. Feldmann, M., Brennan, F.M., Elliott, M.J., Williams, R.O., and Mami, R.N. TNF alpha is an effective therapeutic target for rheumatoid arthritis. Ann. N. Y. Acad. Sci. 766, 272-278, 1995.
11. Gaston, H. Synovial lymphocytes and the aetiology of synovitis. Ann. Rheum. Dis. 52. Suppl. 1, S17-21. 1993.
12. van Dinther Janssen, A.C., Horst, E., Koopman, G., Newmann, W., Scheper, R.J., Meijer, C.J., and Pals, S.T. The VLA-4/VCAM-1 pathway is involved in lymphocyte adhesion to endothelium in rheumatoid synovium. J. Immunol. 147, 4207-4210, 1991.
13. Postigo, A.A., Garcia Vicuna, R., Laffon, A., and Sanchez Madrid, F. The role of adhesion molecules in the pathogenesis of rheumatoid arthritis. Autoimmunity 16, 69-76, 1993.
14. Cronstein, B.N. Adhesion molecules in the pathogenesis of rheumatoid arthritis. Curr. Opin. Rheumatol. 6, 300-304, 1994.
15. Bank, I., Roth, D , Book, M., Guterman, A., Shnirrer, I., Block, R., Ehrenfeld, M., Langevitz, P., Brenner, H., and Pras, M. Expression and functions of very late antigen 1 in inflammatory joint diseases. J. Clin. Immunol. 11, 29-38, 1991.
16. Laffon, A., Garcia Vicuna, R., Humbria, A., Postigo, A.A., Corbi, A,L., de Landazuri, M.O., and Sanchez Madrid, F. Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis. J. Clin. Invest. 88, 546-552, 1991.
17. Morales Ducret, J., Wayner, E., Elices. M.J., Alvaro Gracia, J.M., Zvaifler, N.J., and Firestein, G.S. Alpha 4/beta 1 integrm (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes. J. Immunol. 149, 1424-1431, 1992.
18. Postigo, A.A., Garcia Vicuna, R., Diaz Gonzalez, F., Arroyo, A.G., De Landazun, M.O., Chi Rosso, G., Lobb, R.R., Laffon, A., and Sanchez Madrid, F. Increased binding of synovial T lymphocytes from rheumatoid arthritis to endothelial-leukocyte adhesion molecule-1 (ELAM-1) and vascular cell adhesion molecule-1 (VCAM-1). J. Clin. Invest. 89, 1445-1452, 1992.
19. Takahashi, H., Soderstrom, K., Nilsson, E., Kiessling, R., and Patarroyo, M. Integrms and other adhesion molecules on lymphocytes from synovial fluid and peripheral blood of rheumatoid arthritis patients. Eur. J. Immunol. 22, 2879-2885, 1992.
20. el Gabalawy, H. and Wilkins, J. Beta I (CD29) integrm expression in rheumatoid synovial membranes: an immunohistologic study of distribution patterns. J. Rheumatol 20, 231-237, 1993.
21. Nikkan, L., Aho, H., Yli Jama, T., Larjava, H., Jalkanen, M., and Heino, J. Expression of integrin family of cell adhesion receptors in rheumatoid synovium. Alpha 6 mtegrin subunit in normal and hyperplastic synovial lining cell layer. Am. J Pathol. 142, 1019-1027, 1993.
22. Wilkins, J., Lyttle, D., Sivananthan, K., and el Gabalawy, H. Lymphocyte-synovial cell interactions: a role for beta I and beta 3 integrin-mediated adhesion to cellular fibronectin. Cell. Immunol. 146, 313-323, 1993.
23. Wilkinson, L.S., Edwards, J.C., Poston, R.N., and Haskard, D.O. Expression of vascular cell adhesion molecule-1 in normal and inflamed synovium. Lab. Invest. 68. 82-88, 1993.
24. Johnson, B.A., Haines, G.K., Harlow, L.A., and Koch, A.E. Adhesion molecule expression in human synovial tissue. Arthritis Rheum. 36, 137-146, 1993.
25. Grober, J.S., Bowen, B.L., Ebling, H., Athey, B., Thompson, C.B., Fox, D.A., and Stoolman, L.M. Monocyte-endothelial adhesion in chronic rheumatoid arthritis. In situ detection of selectin and integrin-dependent interactions [see comments], J. Clin. Invest. 91, 26O9-2619, 1993.
26. Szekanecz, Z., Haines, G.K., Lin, T.R., Harlow, L.A., Goerdt, S., Rayan, G., and Koch, A.E. Differential distribution of intercellular adhesion molecules (ICAM-1, ICAM-2, and ICAM-3) and the MS-1 antigen in normal and diseased human synovia. Their possible pathogenetic and clinical significance in rheumatoid arthritis. Arthritis Rheum. 37, 221-231, 1994.
27. Viner, N.J., Gaston, J.S., and Bacon, P.A, Synovial fluid antigen-presenting cell function in rheumatoid arthritis. Clin. Exp. Immunol. 92. 251-255, 1993.
28. Res, P.C., Struijk, L., Leow, A., Daha, M.R., van den Elsen, P.C., and Breedveld, F.C. Inflamed joints of patients with rheumatoid arthritis contain T cells that display in vitro proliferation to antigens present in autologous synovial fluid. Functional analysis on the basis of synovial-fluid-reactive T-cell clones and lines, Hum. Immunol. 40, 291-298, 1994.
29. Tsai, C.. Diaz, L.A., Jr., Singer, N.G., Li, L.L., Kirsch, A.H., Mitra, R., Nickoloff, B.J., Crofford, L.J. and Fox, D.A. Responsiveness of human T lymphocytes to bacterial superantigens presented by cultured rheumatoid arthritis synoviocytes. Arthritis Rheum. 39, 125-136, 1996.
30. Miyake, S., Yagita, H., Maruyama, T., Hashimoto, H., Miyasaka, N., and Okumura, K. Beta 1 integrm-mediated interaction with extracellular matrix proteins regulates cytokine gene expression in synovial fluid cells of rheumatoid arthritis patients. J. Exp. Med. 177, 863-868, 1993.
31. Hynes, R.O. Integrins' versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25, 1992.
32. Lafyatis, R., Remmers, E.F., Roberts, A.B., Yocum, D.E., Sporn, M.B., and Wilder, R.L. Anchorage-independent growth of synoviocytes from arthritis and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. J. Clin. Invest. 83, 1267-1276, 1989.
33. Kumkumian, G.K., Lafyatis, R., Remmers, E.F., Case, J.P., Kim, S.J., and Wilder, R.L. Platelet-derived growth factor and IL-I interactions in rheumatoid arthritis. Regulation of synoviocyte proliferation, prostaglandin production, and collagenase transcription. J. Immunol. 143, 833-837, 1989.
34. Remmers, E.F., Sano, H., and Wilder, R.L. Platelet-derived growth factors and heparin-binding (fibroblast) growth factors in the synovial tissue pathology of rheumatoid arthritis. Semin. Arthritis Rheum. 21, 191-199, 1991.
35. Goddard, D.H., Grossman, S.L., Williams, W.V., Weiner, D.B., Gross, J.L., Eidsvoog, K., and Dasch, J.R. Regulation of synovial cell growth. Coexpression of transforming growth factor beta and basic fibroblast growth factor by cultured synovial cells. Arthritis Rheum. 35, 1296-1303, 1992.
36. Case, J.P., Lafyatis, R., Remmers, E.F., Kumkumian, G.K., and Wilder, R.L. Transin/stromelysin expression in rheumatoid synovium. A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes. Am. J. Pathol. 135, 1055-1064, 1989.
37. Ullrich, A. and Schlessinger, J. Signal transduction by receptors with tyrosine kinase activity. Cell 61, 203-212, 1990
38. Hill, C.S. and Treisman, R. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80, 199-211, 1995.
39. Heldin, C.H. Dimerization of cell surface receptors in signal transduction. Cell 80, 213-223, 1995.
40. Handel, M.L., McMorrow, L.B., and Gravallese, E.M. Nuclear Factor-kB in rheumatoid synovium. Arthritis Rheum. 38, 1762-1770, 1995.
41. Marok, R., Winyard, P.G., Coumbe, A. et al., Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue. Arthritis Rheum. 39, 583-591, 1996.
42. Williams, W.V., VonFeldt, J.M., Ramanujam, T., and Weiner, D.B. Tyrosine kinase signal transduction in rheumatoid synovitis. Semin, Arthritis Rheum. 21, 317-329, 1992.
43. Sano, H., Engleka, K., Mathern, P., Hla, T., Crofford, L.J., Remmers, E.F., Jelsema, C.L., Goldmuntz, E., Maciag, T., and Wilder, R.L. Coexpression of phosphotyrosine-containing proteins, platelet-derived growth factor-B, and fibroblast growth factor-1 in situ in synovial tissues of patients with rheumatoid arthritis and Lewis rats with adjuvant or streptococcal cell wall arthritis. J. Ciin. Invest. 91, 553-565, 1993.
44. Migita, K., Eguchi, K., Tsukada, T., Kawabe, Y., Aoyagi, T., and Nagataki, S. The role of protein kinase in human synovial fibroblast growth. Biochem. Biophys. Res. Commun. 210, 1066-1075, 1995.
45. Springer, T.A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301-314, 1994.
46. Gerntsen, M.E., Kelley, K.A., Ligon, G , Perry, C.A , Shen, C.P., Szczepanski, A., and Carley, W.W. Regulation of the expression of intercellular adhesion molecule 1 in cultured human endothelial cells derived from rheumatoid synovium. Arthritis Rheum. 36, 593-602, 1993.
47. Kriegsmann, J., Keyszer, G.M., Geiler, T., Brauer, R., Gay, R.E., and Gay, S. Expression of vascular cell adhesion molecule-1 mRNA and protein in rheumatoid synovium demonstrated by in situ hybridization and immunohistochemistry. Lab Invest. 72, 209-214, 1995.
48. Tak, P.P., Taylor, P.C., Breedveld, F.C., Smeets, T.J.M., Daha, M.R., Kluin, P.M , Meinders, A.E., and Maini, R.N. Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor a monoclonal antibody treatment in patients with rheumatoid arthritis. Arthritis Rheum. 39, 1077-1081, 1996.
49. Takeuchi, T., Amano, K., Sekine, H., Koide, J., and Abe, T. Upregulated expression and function of integrin adhesive receptors in systemic lupus erythematosus patients with vasculitis. J. Clin Invest. 92, 3008-3016, 1993.
50. Saito, I., Terauchi, K., Shimuta, M., Nisimura, S., Yosino, K., Takeuchi, T., Tsubota, K., and Miyasaka, M. Expression of cell adhesion molecules in the salivary and lacrimal glands of Sj̈ogren's syndrome. J. Clin. Lab. Anal. 7, 180-187, 1993.
51. Amano, K., Sekine, H., Itoh, T., Hosono, O., Koide, J, Takeuchi, T., and Abe, T. An usual variant of Wegener's granulomatosis and the role of integrin adhesion receptors for pulmonary lesion. Jap. J. Rheum 5, 217-226, 1994.
52. Takeuchi, T., Itoh, T., Koide, J., Uchida, S., and Abe, T. Characterization of tyrosine phosphorylation of proteins in in vitro cultured synovial cells from RA. Arthritis Rheum. 38, S214, 1995.
53. Kornberg, L J., Earp, H.S., Turner, C.E., Prockop, C., and Juliano, R.L. Signal transduction by imegrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 mtegrins. Proc. Natl. Acad. Sci. USA 88, 8392-8396, 1991
54. Kapron Bras, C., Fitz Gibbon, L., Jeevaratnam, P , Wilkins, J., and Dedhar, S. Stimulation of tyrosine phosphorylation and accumulation of GTP-bound p21ras upon antibody-mediated alpha 2 beta I integrin activation in T-lymphoblastic cells. J. Biol. Chem. 268, 20701-20704, 1993.
55. Juliano, R.L. and Haskill, S. Signal transduction from the extracellular matrix. J. Cell Biol. 120, 577-585, 1993.
56. Guan, J.L. and Shalloway, D. Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature 358, 690-692, 1992.
57. Hanks, S.K., Calalb, M.B., Harper, M.C., and Patel, S.K. Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin. Proc. Natl. Acad. Sci. USA 89, 8487-8491, 1992.
58. Kornberg, L., Earp, H.S., Parsons, J.T., Schaller, M., and Juliano, R.L. Cell adhesion or integrin clustering increases phosphorylation of a focal adhesionassociated tyrosine kinase. J. Biol. Chem. 267, 23439-23442, 1992.
59. Lipfert, L., Haimovich, B., Schaller, M.D., Cobb, B.S., Parsons, J.T., and Brugge, J.S. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets. J. Cell Biol. 119, 905-912, 1992.
60. Schaller, M.D., Borgman, C.A., Cobb, B.S., Vines, R.R., Reynolds, A.B., and Parsons, J.T. pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc. Natl. Acad. Sci. USA 89, 5192-5196, 1992.
61. Zachary, I., Sinnett Smith, J., Turner, C.E., and Rozengurt, E. Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation of the focal adhesion-associated protein paxillin in Swiss 3T3 cells. J. Biol. Chem. 268, 22060-22065, 1993.
62. Zachary, I. and Rozengurt, E. Focal adhesion kinase (p125FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenes. Cell 71, 891-894, 1992.
63. Weiner, T.M., Liu, E.T., Craven, R.J., and Cance, W.G. Expression of focal adhesion kinase gene and invasive cancer. Lancet 342, 1024-1025, 1993.
64. Ilic, D., Furuta, Y., and Kanazawa, S. et al. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377, 539-544, 1995.
65. Sato, H., Kita., M., and Seiki, M. v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinobiastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines. J. Biol. Chem. 268, 23460-23468, 1993.
66. Vincenti, M.P., Coon, C.I., White, L.A., Barchowsky, A., and Brinckerhoff, C.E. src-related tyrosine kinases regulate transcriptional activation of the interstitial collagenase gene, MMP-1, in interleukin-1-stimulated synovial fibroblasts. Arthritis Rheum. 39, 574-582, 1996.
67. Clark, E.A. and Brugge, J.S. Imegrins and signal transduction pathways: the road taken. Science 268, 233-239, 1995.
68. Schlaepfer, D.D., Hanks, S.K., Hunter, T., and van-der-Geer, P. Integrin- mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372, 786-91, 1994.
69. Pawson, T. Protein modules and signalling networks. Nature 373, 573-80, 1995.