Binding of the α2 integrin I domain to extracellular matrix ligands: Structural and mechanistic differences between collagen and laminin binding

Cell Adhesion and Communication

Volumn 5, Issue 4, 1998, Pages 273-281

  Dickeson, S Kent ^a   Walsh, John J ^a   Santoro, Samuel A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Collagen; Divalent cation; Extracellular matrix; Integrin; Laminin

Indexed keywords

BLOCKING ANTIBODY; CELL SURFACE RECEPTOR; COLLAGEN; EDETIC ACID; INTEGRIN; LAMININ; LAMININ RECEPTOR; MAGNESIUM ION; MANGANESE; SCLEROPROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING KINETICS; EXTRACELLULAR MATRIX; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

EID: 0032467689     PISSN: 10615385     EISSN: None     Source Type: Journal    
DOI: 10.3109/15419069809040297     Document Type: Article

References (23)

1. 1) I domain functions as a ligand-specific recognition sequence for endothelial cell attachment and spreading: Molecular and functional characterization. Blood 84, 3734-3741.
2. 1 antibody. J.Cell Biol. 120, 537-543.
3. Coller B.S., Beer J.H., Scudder L.E. and Steinberg M.H. (1989) Collagen-binding interactions: Evidence for a direct interaction of collagen with platelet gpIa/IIa and an indirect interaction with platelet gpIIb/IIIa mediated by adhesive proteins. Blood 74, 182-192.
4. 1 integrin. J.Biol.Chem. 272, 7661-7668.
5. Elices M.J. and Hemler M.E. (1989) The human integrin VLA-2 is a collagen receptor on some cells and a collagen/laminin receptor on others. Proc. Natl Acad. Sci. USA 86, 9906-9910.
6. 1 (VLA-2, CD49b/CD29). J. Biol Chem. 269, 9659-9663.
7. 1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner. J. Biol. Chem. 269, 26006-26010.
8. 1. J. Biol. Chem. 269, 22811-22816.
9. 2+-independent manner. J. Cell Biol. 119, 1335-1345.
10. Landis R.C., McDowall A., Holness C.L.L., Littler A.J., Simmons D.L. and Hogg N. (1994) Involvement of the "I" domain of LFA-1 in selective binding to ligands ICAM-1 and ICAM-3. J. Cell Biol. 126, 529-537.
11. 1 integrin as a laminin receptor. J.Cell Biol. 109, 2455-2462.
12. Lee J.-O., Bankston L.A., Arnaout M.A. and Liddington R.C. (1995a) Two conformations of the integrin A-domain (I-domain): A pathway for activation? Structure 3, 1333-1340.
13. Lee J.-O., Rieu P., Arnaout M.A. and Liddington R. (1995b) Crystal structure of the A domain from the a subunit of integrin CR3 (CD11b/CD18). Cell 80, 631-638.
14. 2 integrin CR3 (CD11b/CD18) is essential for ligand binding. Cell 72, 857-867.
15. Pischel K.D., Bluestein H.G. and Woods V.L., Jr. (1988) Platelet glycoproteias Ia, Ic, and IIa are physicochemically indistinguishable from the very late activation antigens adhesion-related proteins of lymphocytes and other cell types. J. Clin. Invest. 81, 503-513.
16. Sanger F., Milken S. and Coulson A.R. (1977) DNA sequencing with chain-terminating inhibitors. Proc. Natl Acad. Sci. USA 74, 5463-5467.
17. Santoro S.A. (1986) Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen. Cell 46, 913-920.
18. Santoro S.A., Rajpara S.M., Staatz W.D. and Woods V.L., Jr. (1988) Isolation and characterization of a platelet surface collagen binding complex related to VLA-2. Biochem. Biophys. Res. Commun. 153, 217-223.
19. 1 integrin: A collagen receptor on platelets and other cells. Thromb. Haemost. 74, 813-821.
20. Schwartz M.A., Schaller M.D. and Ginsberg M.H. (1995) Integrins: Emerging paradigms of signal transduction. Annu. Rev. Cell Dev. Bio. 11, 549-599.
21. ++-dependent adhesion of platelets to collagen. J. Cell Biol. 108, 1917-1924.
22. 2 subunit (Platelet GPIa): Homology to outer integrins and the presence of a possible collagen-binding domain. J. Cell Biol. 109, 397-407.
23. 2 I-domain is a binding site for collagens. J. Cell Sci. 108, 1629-1637.