Effect of nimodipine and N-acetylcysteine on lipid peroxidation after experimental spinal cord injury

Neurosurgical Review

Volumn 21, Issue 4, 1998, Pages 260-264

  Kaynar, Mehmet Yasar ^a   Erdinçler, Pamir ^a,b   Tadayyon, Elyass ^a   Belce, Ahmet ^a   Gümüstas, Korax ^a   Çiplak, Nejat ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b NONE   (Turkey)

Author keywords

Lipid peroxidation; N acetylcysteine; Nimodipine; Spinal cord injury

Indexed keywords

ACETYLCYSTEINE; MALONALDEHYDE; NIMODIPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FEMALE; INTERMETHOD COMPARISON; INTRAPERITONEAL DRUG ADMINISTRATION; LAMINECTOMY; LIPID PEROXIDATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD COMPRESSION; SPINAL CORD INJURY; TREATMENT OUTCOME;

ACETYLCYSTEINE; ANIMALS; CALCIUM CHANNEL BLOCKERS; FEMALE; FREE RADICAL SCAVENGERS; LIPID PEROXIDATION; NIMODIPINE; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES;

EID: 0032467121     PISSN: 03445607     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01105782     Document Type: Article

References (36)

1. ARUOMA OI, B HALLIWELL, BM HOEY: The antioxidant action of N-acetylcysteine: its reaction with hydrogene peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Rad Biol Med 6 (1989) 593-597
2. BALENTINE JD, CW HILTON: Calcification of axons in experimental spinal cord trauma. Ann Neurol 2 (1980) 520-523
3. BALENTINE JD, CW HILTON: Ultrastructural pathology of axons and myelin in calcium-induced myelopathy. J Neuropathol Exp Neurol 39 (1980) 339
4. BARTH SA, G INSELMANN, R ENGEMANN, HT HEIDEMANN: Influences of Ginkgo biloba on Cyclosporin A induced lipid peroxidation in human liver microsomes in comparison to vitamin E, glutathione and N-acetyl-cysteine. Biochem Pharmacol 41 (1991) 1521-1526
5. BARUT S, A CANBOLAT, T BILGE, Y AYDIN, B ÇOKNESELI, U KAYA: Lipid peroxidation in experimental spinal cord injury: time-level relationship. Neurosurg Rev 16 (1993) 53-59
6. BERNARD GR, WD LUCHT, ME NIEDERMEYER, ML OGLETREE, KL BRIGHAM: Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function. J Clin Ivest 73 (1984) 1772-1784
7. BLACK, P, RS MARKOWITZ, SD FINKELSTEIN, K MCMONAGLE-STRUCKO, JA GILLESPIE: Experimental spinal cord injury: effect of a calcium channel antagonist (nicardipine). Neurosurgery 22 (1988) 61-66
8. BRACKEN MB, MJ SHEPARD, WF COLLINS, TR HOLFORD, W YOUNG, BASKIN et al. A randomized controlled trial of methyl prednisolone or naloxone in the treatment of acute spinal cord injury: results of the second NASCIS. N Engl J Med 322: (1990) 1405-1411
9. CASINI AF, M FERRALI, A POMPELLA, E MAELLARE, M COMPORTI: Lipid peroxidation and cellular damage in extrahepatic tissues of Bromobenzene-intoxicated mice. Am J Pathol (123 (1986) 520-531
10. CHOI D: Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci 11 (1988) 465-469
11. DEMOPOULOS HB, ES FLAMM, DD PIETRONIGRO, ML SELIGMAN: The free radical pathology and the microcirculation in the major central nervous disorders. Acta Physiol Scand 492 (1980) 91-119
12. DEMOPOULOS HB, ES FLAMM, ML SELIGMAN, DD PIETRONIGRO: Oxygen free radicals in central nervous system ischemia and trauma. In: AUTOR AP (ed): Pathology of Oxygen. Academic Press, New York, 1982. pp 127-155
13. DEMOPOULOS HB, ES FLAMM, ML SELIGMAN, JA MITAMURA, J RANSOHOFF: Membrane perturbations in central nervous system injury: theorectical basis for free radical damage and a reviews of the experimental data. In: POPP AJ, RS BOURKE, LR NELSON, HK KIMELBERG (eds): Neural Trauma, Raven Press, New York, 1979. pp 63-78
14. FADEN AI: Pharmacotherapy in spinal cord injury: a artical review of recent developments. Clin Neuropharmacol 10 (1987) 193-204
15. FORD RWJ, DN MALM: Failure of nimodipine to reverse acute experimental spinal cord injury. CNS Trauma 2 (1985) 9-17
16. GUHA A, CH TATOR, I PIPER: Increase in rat spinal cord blood flow with the calcium channel blocker, nimodipine. J Neurosurg 63 (1985) 250-259
17. GUHA A, CH TATOR, I PIPER: Effect of a calcium channel blocker on posttraumatic spinal cord blood flow. J Neurosurg 66 (1987) 423-430
18. HAGHIGHI SS, BB CHEHRAZI, FC JR WAGNER: Effect of nimodipine-associated hypotension on recovery from acute spinal cord injury in cats. Surg Neurol 29 (1988) 293-297
19. HAGHIGHI SS, T STIENS, JJ ORE, R MADSEN: Evaluation of the calcium channel antagonist nimodipine after experimental spinal cord injury. Surg Neurol 39 (1993) 403-408
20. HALL ED: Lipid antioxidants in acute central nervous system injury. Am Emerg Med 22 (1993) 1022-1027
21. HALL ED, RJ TRAYSTMAN (eds): Secondary tissue damage after CNS injury. Current concepts. The Upjohn Company, Kalamazoo, Mich, 1993, pp 12-13
22. HALL ED, DL WOLF: A pharmacological analysis of the pathophysiological mechanisms of posttraumatic spinal cord ischemia. J Neurosurg 64 (1986) 951-961
23. ++ Accumulation in experimental spinal cord trauma. Brain Res 211 (1981) 476-479
24. HEFFEZ DS, V PASSOVEAU: Effect of nimodipine on cerebral metabolism during ischemia and recirculation in the mongolian gerbil. J Cereb Blood Flow Metab 5 (1985) 523-527
25. HIRSCHFELD A, W YOUNG: Trends in spinal cord injury research. In: ALDERSON JD, EAM FROST (eds): Spinal cord injuries: anaesthetic and associated care. Butterworths, London, 1990, pp 199-232
26. HITCHON PW, T HANSEN, T MCKAY, RA GIRTON, GN DYSTE, MD SOKOLL: Nicardipine after spinal cord compression in the lamb. Surg Neurol 31 (1989) 101-110
27. HOLTZ A, B NYSTROM, B HERDIN: Spinal cord injury in rats: inability of nimodipine or antineurophil serum to improve spinal cord blood flow or neurologic status. Acta Neurol Scand 79 (1989) 460-467
28. KAYNAR MY, M HANCI, A KAFADAR, K GUMUSTAS, A BELCE, N CIPLAK: The effect of duration of compression on lipid peroxidation after experimental spinal cord injury. Neurosurg Rev 21 (1998) 117-120
29. KWO S, W YOUNG, V DE CRESCITE: Spinal cord sodium, potassium, calcium and water concentration changes in rats after graded contusion injury. Neurotrauma 6 (1989) 13-24
30. LUCHT WD, DK ENGLISH, GR BERNARD: Prevention of release of granulocyte aggregants into sheep lung lymph following endotoxemia by N-acetylcysteine. Am J Med Sci 294 (1987) 161-167
31. MOHAMED AA, J MCCULLOCH, AD MENDELOW, GM TEASDALE, AM HARPER: Effect of the calcium antagonist nimodipine on local cerebral blood flow: relationship to arterial blood pressure. J Cereb Blood Flow Metab 5 (1985) 26-33
32. OLSON RD, JS MAC DONALD, CJ VAN BOXTEL, RC BOERTH, RD HARBISON, AE SLONIN, RW FREEMAN, JA OATES: Regulatory role of glutathion on soluble sulfhydryl groups in the toxicity of Adriamycin. J Pharmacol Exp Ther 215 (1980) 450-454
33. STOKES BT, P FOX, G HOLLINDEN: Extracellular calcium activity in the injured spinal cord. Exp Neurol 80 (1983) 561-572
34. STOO WE, RD OLSON, RC BOERTH: Efficacy of sulfhydryl compounds as inhibitors of iron-dependent doxorubicin-enhanced lipid peroxidation. Res Commun Chem Path of Pharmacol 48 (1985) 291-303
35. TIEN M, JR BUCHER, SD AUST: Thiol-dependent lipid peroxidation. Biochem Biophy Res Commun 107 (1982) 279-285
36. YOUNG W, I KOREH: Potassium and calcium changes in injured spinal cords. Brain Res 365 (1986) 42-53