Fluorescence spectroscopic investigation of effect of excipients on epidermal barrier and transdermal systems

Journal of Investigative Dermatology Symposium Proceedings

Volumn 3, Issue 2, 1998, Pages 128-130

  Jasti, Bhaskara R ^a,b   Abraham, William ^a,c  

^a Cygnus Therapeutic Systems   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MONSANTO COMPANY   (United States)

Author keywords

Fluorescence spectroscopy; Lifetime; Limiting anisotrope fluorescence; Silicone adhesives; Stratum corneum; Transdermal drug delivery

Indexed keywords

1,6 DIPHENYL 1,3,5 HEXATRIENE; EXCIPIENT; OLEIC ACID; PROPANEDIOL DERIVATIVE; PROPYLENE GLYCOL LAURATE; SILICONE; UNCLASSIFIED DRUG;

ANISOTROPY; ARTICLE; CADAVER; CONTROLLED STUDY; DIELECTRIC CONSTANT; DRUG DELIVERY SYSTEM; EPIDERMIS; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN TISSUE; PERMEABILITY BARRIER; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0032466724     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: 10.1038/jidsymp.1998.26     Document Type: Article

References (23)

1. Abraham W, Downing DT: Lamellar structures formed by stratum corneum lipids in vitro: A deuterium nuclear magnetic resonance (NMR) study. Pharmaceut Res 9:1415-1421, 1992
2. Barry BW: Mode of action of penetration enhancers in human skin. J Control Rel 6:85-97, 1987
3. Blank IH: Cutaneous barriers. J Invest Dermatol 45:249-256, 1965
4. Bouwstra JA, Bodde HE: Human SC barrier impairment by N-alkyl-azacycloheptanones: A mechanistic study of drug flux enhancement, Azone mobility, and protein and lipid perturbation. In: Smith EW and Maibach HI (eds). Percutaneous Penetration Enhancers. Boca Raton: CRC Press, 1995, pp. 137-157
5. Cleary GW, Roy SD: Transdermal drug delivery composition. US Patent 4906463, 1990
6. Elias PM: Epidermal lipids, barrier function, and desquamation. J Invest Dermatol 80 (Suppl.):44s-49s, 1983
7. Engel LW, Prendergast FG: Values for and significance of order parameters and "cone angles" of fluorophore rotation in lipid bilayers. Biochemistry 2:7338-7348, 1981
8. Francoeur ML, Golden GM, Potts RO: Oleic acid: Its effects on stratum corneum in relation to (trans) dermal drug delivery. Pharm Res 7:621-627, 1990
9. Garrison TMD, Doh LM, Potts RO, and W: Abraham, Effect of oleic acid on human epidermis: Fluorescence spectroscopic investigation. J Control Rel 31:263-269, 1994
10. Holman BP, Spies TF, Boddé HE: An optimized freeze-fracture replication procedure for human skin. J Invest Dermatol 94:336-340, 1990
11. Irion GD, Garrison MD, Abraham W: Effect of PGML excipient mixture in a transdermal system on the in vitro transport of estradiol across skin. Pharm Res 12:1618-1622, 1995
12. Jameson DM, Gratton E, Hall RD: The measurement and analysis of heterogeneous emissions by multifrequency phase and modulation fluorometry. Appl Spectros Rev 20:55-106, 1984
13. Jarry JP, Monnerie L: Fluorescence depolarization study of the glass-rubber relaxation in a polyisoprene. Macromolecules 12:927-932, 1979
14. Lakowicz JR: Principles of Fluorescence Spectroscopy. New York: Plenum Press, 1983
15. Lakowicz JR, Cherek H, Maliwal BP, Gratton E: Time-resolved fluorescence anisotropies of diphenylhexatriene and perylene in solvents and lipid bilayers obtained from multifrequency phase-modulation fluorometry. Biochemistry 24:376-383, 1985
16. Lentz BR: Membrane fluidity from fluorescence anisotropy measurements. In: Loew LM (ed.). Spectroscopic Membrane Probes, Vol. 1, Ch. 2. Boca Raton: CRC Press, 1988, pp. 13-41
17. Potts RO, Guy RH (eds): Mechanisms of Transdermal Drug Delivery. New York: Marcel Dekker, 1997
18. Michaels AS, Chandrasekaran SK, Shaw JE: Drug permeation through human skin: Theory and in vitro experimental measurement. Am Inst Chem Eng J 21:985-996, 1975
19. Noel C, Laupretre F, Friedrich C, Leonard C, Halary JL, Monnerie L: ESR and fluorescence polarization investigation of molecular motions in poly (vinylidene fluoride) and some related copolymers. Macromolecules 19:201-210, 1986
20. Onpipattanakul B, Burnette RR, Potts RO, Francoeur ML: Evidence that oleic acid exists in a separate phase within stratum corneum lipids. Pharm Res 8:350-354, 1991
21. Smith EW, Maibach HI (eds): Percutaneous Penetration Enhancers. Boca Raton: CRC Press, 1995
22. Pfister WR, Hsieh DST: Permeation enhancers compatible with transdermal drug delivery systems. Part I and II. Pharm Tech October, 1990
23. Rehfeld SJ, Plachy WZ, Williams TM, Elias PM: Calorimetric and electron spin resonance examination of lipid phase transitions in human stratum corneum: Molecular basis for normal cohesion and abnormal desquamation in recessive X-linked ichthyosis. J Invest Dermatol 91:449-505, 1988