Spinal cord protection by papaverine and intrathecal cooling during aortic crossclamping

Journal of Cardiovascular Surgery

Volumn 39, Issue 6, 1998, Pages 839-842

  Sun, J ^a   Hirsch, D ^a   Svensson, G ^a  

^a LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

Aorta thoracic surgery; Excitatory aminoacid antagonists; Ischemia etiology; Papaverine, administration and dosage; Paraplegia prevention and control; Spinal cord blood supply

Indexed keywords

4 PHOSPHONOMETHYLPIPECOLIC ACID; PAPAVERINE; RINGER SOLUTION;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA CLAMPING; ARTERY DILATATION; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; COOLING; DEATH; EPIDURAL CATHETER; INTRATHECAL DRUG ADMINISTRATION; LAMINECTOMY; LUMBAR ARTERY; MALE; MUSCLE SPASM; NEUROPROTECTION; NONHUMAN; PARALYSIS; PARAPLEGIA; PROTECTION; SPINAL CORD; SPINAL CORD BLOOD FLOW; SPINAL CORD ISCHEMIA; STANDING; SWINE; TISSUE PERFUSION; WALKING;

ADMINISTRATION, TOPICAL; ANIMALS; AORTA, THORACIC; COLD; DISEASE MODELS, ANIMAL; INTUBATION, INTRATRACHEAL; ISCHEMIA; ISOTONIC SOLUTIONS; MALE; PAPAVERINE; PARAPLEGIA; PARASYMPATHOLYTICS; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; SPINAL CORD; SWINE; VASCULAR SURGICAL PROCEDURES; VASODILATION; VERTEBRAL ARTERY;

EID: 0032466245     PISSN: 00219509     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Svensson LG, Crawford ES. Aortic dissection and aortic aneurysm surgery. Clinical observations, experimental investigations and statistical analyses. Part I. Curr Probl Surg 1992;19:819-912.
2. Svensson LG, Crawford ES. Aortic dissection and aortic aneurysm surgery. Clinical observations, experimental investigations and statistical analyses. Part III. Curr Probl Surg 1993;30:1-172.
3. Svensson LG, Crawford ES, Patel V, McLean TR, Jones JW, DeBakay ME. Spinal oxygenation, blood supply localization, cooling, and function with aortic clamping. Ann Thorac Surg 1992;54:74-9.
4. Svensson LG, Von Ritter CM, Groeneveld HT, Rickards ES, Hunter SJS, Robinson MF et al. Cross-clamping of the thoracic aorta: influence of aortic shunts, laminectomy, papaverine, calcium channel blocker, allopurinol and superoxide dismutase on spinal cord blood flow and paraplegia in baboons. Ann Surg 1986;204:38-47.
5. Berguer R, Porto J, Fedoronko B, Dragovic L. Selective deep hypothermia of the spinal cord prevents paraplegia after aortic cross-clamping in the dog model. J Vasc Surg 1992;15:62-71.
6. Allen BT, Christopher GD, Osborne D, Karl I. Spinal cord ischemia and reperfusion metabolism: the effect of hypothermia. J Vasc Surg 1994;19:332-40.
7. Rokkas CK, Cronin CS, Nitta T, Helfrich LR Jr, Lobner DC, Choi DW et al. Profound systemic hypothermia inhibits the release of neurotransmitter amino acids in spinal cord ischemia. J Thorac Cardiovasc Surg 1995;10:27-35.
8. Kochhar A, Zivin JA, Mazzarella. Pharmacologic studies of the neuroprotective actions of a glutamate antagonist in ischemia. J Neutrauma 1991;8:175-86.
9. Bennett DA, Lehmann J, Bernard PS, Liebman JM, Williams M, Wood PL et al. CGS 19755: a novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant, anxiolytic and anti-ischemic properties. Prog Clin Biol Res 1990;361:519-24.
10. Svensson LG, Patel VP, Robinson MF, Ueda T, Roeham JOF, Crawford ES. Influence of preservation or perfusion of intraoperatively identified spinal cord blood supply on spinal motor evoked potentials and paraplegia after aortic surgery. J Vasc Surg 1991;13:355-65.
11. Svensson LG, Patel V, Coselli JS, Crawford ES. Preliminary report of localization of spinal cord blood supply by hydrogen during aortic operations. Ann Thorac Surg 1990;49:528-36.
12. Svensson LG, Crawford ES. Neural ischemia. In: Cardiovascular and vascular disease of the aorta. 1st edition. Philadelphia: WB Saunders, 1996.
13. Simpson Jr RK, Robertson CS, Goodman JC. Spinal cord ischemia-induced elevation of amino acids: extracellular measurement with microdialysis. Neurochem Res 1990;15:635-9.
14. Redmond JM, Gillinov AM, Zehr KJ, Blue ME, Troncoso JC, Reitz BA et al. Glutamate excitotoxicity: A mechanism of neurologic injury associated with hypothermic circulatory arrest. J Thorac Cardiovasc Surg 1994;107:776-87.
15. Rokkas CK, Helfrich LR Jr, Lobner DC, Choi DW, Kouchoukos NT. Dextroophan inhibits the release of excitatory amino acids during spinal cord ischemia. Ann Thorac Surg 1994;58:312-20.