Dehydrogenation of 3-phenoxybenzyl alcohol in isolated perfused rabbit skin, skin homogenate and purified dehydrogenases

Skin Pharmacology and Applied Skin Physiology

Volumn 11, Issue 4-5, 1998, Pages 250-257

  Bast, G E ^a   Kampffmeyer, H G ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

3 Phenoxybenzyl alcohol; Dehydrogenation; Metabolism; Rabbit; Skin

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; ALCOHOL DEHYDROGENASE; LIVER ENZYME; METYRAPONE;

ANIMAL TISSUE; ARTICLE; EAR; ENZYME PURIFICATION; HORSE; LIVER; NONHUMAN; PRIORITY JOURNAL; RABBIT; SKIN; TISSUE HOMOGENATE;

ALCOHOL DEHYDROGENASE; ANIMALS; BENZYL ALCOHOLS; BIOTRANSFORMATION; BLOTTING, WESTERN; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; INDICATORS AND REAGENTS; NAD; OINTMENTS; PERFUSION; RABBITS; SKIN; SUBCELLULAR FRACTIONS;

EID: 0032465444     PISSN: 14222868     EISSN: None     Source Type: Journal    
DOI: 10.1159/000029834     Document Type: Article

References (14)

1. Bast GE, Taeschner D, Kampffmeyer HG: Permethrin absorption not detected in single-pass perfused rabbit ear, and absorption with oxidation of 3-phenoxybenzyl alcohol. Arch Toxicol 1997;71:179-186.
2. Parkinson A: Biotransformation of xenobiotics; in Klaasen CD, Amudor MO, Doull J (eds): Toxicology. New York, McGraw-Hill, 1996, pp 113-186.
3. Henrikus BM, Breuer W, Kampffmeyer HG: Dermal metabolism of 4-nitrophenol and 4-nitroanisole in single-pass perfused rabbit ears. Xenobiotica 1991;21:1229-1241.
4. Wilkin JK, Stewart JH: Substrate specificity of human cutaneous alcohol dehydrogenase and erythema provoked by lower aliphatic alcohols. J Invest Dermatol 1987;88:452-454.
5. Behrendt H, Kampffmeyer HG: Absorption and ester cleavage of methyl salicylate by skin of single-pass perfused rabbit ear. Xenobiotica 1989;19:131-141.
6. Bast GE, Kampffmeyer HG: Absorption and metabolism of hydrocortisone 21-butyrate, 21-hemisuccinate and hydrocortisone by skin of rabbit ear during single-pass perfusion. Xenobiotica 1994;24:1029-1042.
7. Sweat ML, Bryson MK: The role of phosphopyridine nucleotides in the metabolism of cortisol by peripheral tissue. Biochim Biophys Acta 1960;44:217-233.
8. 4. I. DNA packing events. J Mol Biol 1973;80:575-599.
9. Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some application. Proc Natl Acad Sci USA 1979;76:4350-4354.
10. 450, form 2, in microsomal preparations bound directly to nitrocellulose paper using a modified peroxide-immunostaining procedure. Anal Biochem 1984;136:390-396.
11. Leatherbarrow RJ: Enzfitter, a Non-Linear Regression Data Analysis Program for IBM PC. Amsterdam, Elsevier, 1987.
12. Leskovac V, Trivic S, Anderson BM: Yeast alcohol dehydrogenase catalysed reduction of p-nitroso-N,N-dimethylaniline by NADH. Ital J Biochem 1995;50:1257-1264.
13. Chen H, Namkung MJ, Juchau MR: Biotransformation of all-trans-retinol and all-trans retinal to all-trans-retinoic acid in rat conceptional homogenates. Biochem Pharmacol 1995;50:1257-1264.
14. Didierjean L, Carraux P, Grand D, Sass JO, Nau H, Saurat J-H: Topical retinaldehyde increases skin content of retinoic acid and exerts biologic activity in mouse skin. J Invest Dermatol 1996;107:714-719.