Double-blind comparison of single-dose alatrofloxacin and cefotetan as prophylaxis of infection following elective colorectal surgery

American Journal of Surgery

Volumn 176, Issue 6 A, 1998, Pages 46S-52S

  Milsom, Jeffrey W ^a,g   Smith, David L ^g   Corman, Marvin L ^b,f   Howerton, Richard A ^c   Yellin, Albert E ^d   Luke, David R ^e  

^a LERNER RESEARCH INSTITUTE   (United States)

^b Sansum Clinic   (United States)

^c Department of General Surgery   (United States)

^d LAC USC MEDICAL CENTER   (United States)

^e PFIZER INC   (United States)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^g Box 1259 ^*

Author keywords

[No Author keywords available]

Indexed keywords

ALATROFLOXACIN; CEFOTETAN;

ADULT; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTEREMIA; CLINICAL TRIAL; COLORECTAL SURGERY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG SAFETY; FEMALE; HUMAN; INFECTION PREVENTION; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; SURGICAL INFECTION; TISSUE DISTRIBUTION; TREATMENT OUTCOME;

EID: 0032465045     PISSN: 00029610     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9610(98)00220-7     Document Type: Article

References (33)

1. Polk HC Jr, Lopez-Mayor JF. Postoperative wound infection: a prospective study of determinant factors and prevention. Surgery. 1969;66:97-103.
2. Coppa GF, Eng K. Factors involved in antibiotic selection in elective colon and rectal surgery. Surgery. 1988;104:853-858.
3. Gorbach SL. Antimicrobial prophylaxis for appendectomy and colorectal surgery. Rev Infect Dis. 1991;13(suppl 10):S815-S820.
4. Arnaud JP, Bellissant E, Boissel P, et al. Single-dose amoxycillin-clavulanic acid vs. cefotetan for prophylaxis in elective colorectal surgery: a multicentre, prospective, randomized study. J Hosp Infect. 1992;22(suppl A):23-32.
5. Hershman MJ, Swift DTR, Logan WA, et al. Prospective comparative study of cefotetan with piperacillin for prophylaxis against infection in elective colorectal surgery. J R Coll Surg Edinb. 1990; 35:29-32.
6. Morton AL, Taylor EW, Lindsay G, Wells GR. A multicenter study to compare cefotetan alone with cefotetan and metronidazole as prophylaxis against infection in elective colorectal operations. Surg Gynecol Obstet. 1989;169:41-45.
7. Jagelman DG, Fabian TG, Nichols RL, et al. Single-dose cefotetan versus multiple-dose cefoxitin as prophylaxis in colorectal surgery. Am J Surg. 1988;155:71-76.
8. Martin C, Portet C, Lambert D, et al. Pharmacokinetics and tissue penetration of single-dose cefotetan used for antimicrobial prophylaxis in patients undergoing colorectal surgery. Antimicrob Agents Chemother. 1992;36:1115-1118.
9. Kujath P, Düsel W, Bruch H-P, Kees F. The pharmacokinetic properties of cefotetan and its relevance for prophylaxis in elective colorectal surgery. Chemioterapia. 1988;7:229-232.
10. Spangler SK, Jacobs MR, Appelbaum PC. Activity of CP-99,219 [trovafloxacin] compared with those of ciprofloxacin, grepafloxacin, metronidazole, cefoxitin, piperacillin, and piperacillin-tazobactam against 489 anaerobes. Antimicrob Agents Chemother. 1994;38:2471-2476.
11. Gooding BB, Jones RN. In vitro antimicrobial activity of CP-99,219, a novel azabicyclo-naphthyridone. Antimicrob Agents Chemother. 1993;37:349-353.
12. Child J, Andrews J, Boswell F, et al. The in-vitro activity of CP-99,219, a new naphthyridone antimicrobial agent: a comparison with fluoroquinolone agents. J Antimicrob Chemother. 1995;35: 869-876.
13. Teng R, Harris SC, Nix DE, et al. Pharmacokinetics and safety of trovafloxacin (CP-99,219), a new quinolone antibiotic, following administration of single oral doses to healthy male volunteers. J Antimicrob Chemother. 1995;36:385-394.
14. Gorbach SL, Condon RE, Conte JE Jr, et al. Evaluation of new anti-infective drugs for surgical prophylaxis. Clin Infect Dis. 1992; 15(suppl 1):S313-S338.
15. Williams DJ, Hopkins S. Safety and tolerability of intravenous to oral treatment and single dose intravenous or oral prophylaxis with trovafloxacin. Am J Surg. 1998;176(Suppl 6A):74S-79S.
16. Melnik G, Schwesinger WH, Dogolo LC, Teng R, Vincent J. Concentrations of trovafloxacin in colonic tissue and peritoneal fluid after intravenous infusion of the prodrug alatrofloxacin in patients undergoing colorectal surgery. Am J Surg. 1998;176(Suppl 6A):14S-17S.
17. Clarke JS, Condon RE, Bartlett JG, et al. Preoperative oral antibiotics reduce septic complications of colon operations: results of a prospective, randomized, double-blind clinical study. Ann Surg. 1977;186:251-259.
18. Nichols RL, Broido P, Condon RE, et al. Effect of preoperative neomycin-erythromycin intestinal preparation on the incidence of infectious complications following colon surgery. Ann Surg. 1973; 178:453-462.
19. Bartlett JG, Condon RE, Gorbach SL, et al. Veterans Administration Cooperative Study on bowel preparation for elective colorectal operations: impact of oral antibiotic regimen on colonic flora, wound irrigation cultures and bacteriology of septic complications. Ann Surg. 1978;188:249-254.
20. Gulglielmo BJ, Hohn DC, Koo PJ, et al. Antibiotic prophylaxis in surgical procedures: a critical analysis of the literature. Arch Surg. 1983;118:943-955.
21. Schoetz DJ, Roberts PL, Murray JJ, et al. Addition of parenteral cefoxitin to regimen of oral antibiotics for elective colorectal operations. Ann Surg. 1990;212:209-212.
22. Condon RE, Bartlett JG, Greenlee H, et al. Efficacy of oral and systemic antibiotic prophylaxis in colorectal operations. Arch Surg. 1983;118:496-501.
23. Playforth MJ, Smith GM, Evans M, Pollock AV. Antimicrobial bowel preparation: oral, parenteral, or both? Dis Colon Rectum. 1988;31:90-93.
24. Stellato TA, Danziger LH, Gordon N, et al. Antibiotics in elective colon surgery: a randomized trial of oral, systemic, and oral/systemic antibiotics for prophylaxis. Am Surg. 1990;56:251-254.
25. Nichols RL, Condon RE. Preoperative preparation of the colon. Surg Gynecol Obstet. 1971;132:323-337.
26. Irvin TT, Goligher JC. Aetiology of disruption of intestinal anastomosis. Br J Surg. 1973;60:461-463.
27. Wolff BG, Beart RW, Dozois RR, et al. A new bowel preparation for elective colon and rectal surgery. Arch Surg. 1988;123: 895-900.
28. Fleites RA, Marshall JB, Eckhauser ML, et al. The efficacy of polyethylene glycol-electrolyte lavage solution versus traditional mechanical bowel preparation for elective colonic surgery: a randomized, prospective, blinded clinical trial. Surgery. 1985;98:708-717.
29. Periti P, Mazzei T, Tonelli F. Single-dose cefotetan versus multiple-dose cefoxitin - antimicrobial prophylaxis in colorectal surgery. Dis Colon Rectum. 1989;32:121-127.
30. Jensen LS, Anderson A, Fristrip SC, et al. Comparison of one dose versus three doses of prophylactic antibiotics, and the influence of blood transfusion, on infectious complications in acute and elective colorectal surgery. Br J Surg. 1990;77:513-518.
31. Haley RW, Culver DH, Morgan WM, et al. Identifying patients at high risk of surgical wound infection. Am J Epidemiol. 1985;121:206-215.
32. Periti P, Tonelli F, Mazzei T, et al. Antimicrobial chemoimmunoprophylaxis in colorectal surgery with cefotetan and thymostimulan: prospective, controlled multicenter study. J Chemother. 1993;5:37-42.
33. Walker AJ, Taylor EW, Lindsay G, et al. A multicentre study to compare piperacillin with the combination of netilmicin and metronidazole for prophylaxis in elective colorectal surgery undertaken in district general hospitals. J Hosp Infect. 1988;11:340-348.