The mechanisms of action of and β-isoforms of antithrombin

Blood Coagulation and Fibrinolysis

Volumn 9, Issue SUPPL. 3, 1998, Pages

  Swedenborg, J ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Antithrombin; Glycosaminoglycans; Isoforms; Smooth muscle cell proliferation

Indexed keywords

ANTITHROMBIN; HEPARIN; ISOPROTEIN; THROMBIN;

ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; BLOOD CLOT LYSIS; CONFERENCE PAPER; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RABBIT; THROMBOSIS; VASCULAR SMOOTH MUSCLE; ANIMAL; BLOOD; CELL DIVISION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; PATHOLOGY; PROTEIN CONFORMATION; REVIEW;

ANIMALS; ANTITHROMBINS; CELL DIVISION; HEPARIN; HUMANS; MUSCLE, SMOOTH, VASCULAR; PROTEIN CONFORMATION; PROTEIN ISOFORMS; RABBITS; THROMBIN;

EID: 0032464975     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (26)

1. Conard J, Brosstad F, Lie Larsen M, Samama M, Abildgaard U. Molar antithrombin concentration in normal human plasma. Haemostasis 1983; 13: 363-368.
2. Olson ST, Bjork I. Role of protein conformational changes, surface approximation and protein cofactors in heparin-accelerated antithrombin-proteinase reactions. Adv Exp Med Biol 1992; 313: 155-165.
3. Marcum JA, Rosenberg RD. Anticoagulantly active heparin-like molecules from vascular tissue. Biochemistry 1984; 23: 1730-1737.
4. Wight TN. Cell biology of arterial proteoglycans. Arteriosclerosis 1989; 9: 1-20.
5. Nydahl S, Frebelius S, Swedenborg J. Inhibition of thrombin on subendothelium. Studies on rabbit aorta, ex vivo. Eur Surg Res 1989; 21: 287-295.
6. Tollefsen DM, Pestka CA, Monafo WJ. Activation of heparin cofactor II by dermatan sulfate. J Biol Chem 1983; 258: 6713-6716.
7. Peterson CB, Blackburn MN. Isolation and characterization of an antithrombin III variant with reduced carbohydrate content and enhanced heparin binding. J Biol Chem 1985; 260: 610-615.
8. Brennan SO, George PM, Jordan RE. Physiological variant of antithrombm-III lacks carbohydrate sidechain at Asn 135. FEBS Lett 1987; 219: 431-436.
9. Witmer MR, Hatton MW. Antithrombin III-beta associates more readily than antithrombin III-alpha with uninjured and de-endothelialized aortic wall in vitro and in vivo. Arterioscler Thromb 1991; 11: 530-539.
10. Carlson TH. Effect of heparin on the vascular distribution of I-antithrombin III isoforms in rabbits. Thromb Res 1989; 55: 471-480.
11. Frebelius S, Nydahl S, Swedenborg J. Coagulant and noncoagulant thrombin enzymatic activity on the endothelium. Blood Coag Fibrinol 1990; 1: 285-292.
12. Nydahl S, Frebelius S, Swedenborg J. Effect of heparin on thrombin inhibition in the microcirculation. Thromb Haemost 1993; 69: 41-44.
13. Bock SC, Lu A, Zuo Y, Frebelius S, Swedenborg J. Antithrombin III isoforms in the human vessel wall. Thromb Haemost 1997; Supplement: 433.
14. Pasche B, Swedenborg J, Frebelius S, Olsson P. Heparin Cofactor II significance for the inhibition of thrombin at the injured vessel wall. Thromb Res 1991; 62: 409-419.
15. Pasche B, Swedenborg J, Hedin U, Olsson P, Ljungqvist A. Thrombin-inhibitory capacity of the injured vessel wall. Thromb Res 1991; 62: 531-544.
16. Frebelius S, Hedin U, Swedenborg J. Thrombogenicity of the injured vessel wall - role of antithrombin and heparin. Thromb Haemost 1994; 71: 147-153.
17. Frebelius S, Isaksson S, Swedenborg J. Thrombin inhibition by antithrombin III on the subendothelium is explained by the isoform AT beta. Arterioscler Thromb Vasc Biol 1996; 16: 1292-1297.
18. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993; 362: 801-809.
19. Clinton SK, Libby P. Cytokines and growth factors in atherogenesis. Arch Pathol Lab Med 1992; 116: 1292-1300.
20. Vu TK, Hung DT, Wheaton VI, Coughlin SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991; 64: 1057-1068.
21. Nelken NA, Soifer SJ, O'Keefe J, Vu T-K, Charo IF, Coughlin SR. Thrombin receptor expression in normal and atherosclerotic human arteries. J Clin Invest 1992; 90: 1614-1621.
22. Sarembock IJ, Gertz SD, Gimple LW, Owen RM, Powers ER, Roberts WC. Effectiveness of recombinant desulphatohirudin in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits. Circulation 1991; 84: 232-243.
23. Kanthou C, Parry G, Wijelath E, Kakkar VV, Demoliou-Mason C. Thrombin-induced proliferation and expression of platelet-derived growth factor A-chain gene in human vascular smooth muscle cells. FEBS Lett 1992; 314: 143-148.
24. Hedin U, Frebelius S, Sanchez J, Dryjski M, Swedenborg J. Antithrombin III inhibits thrombin-induced proliferation in human arterial smooth muscle cells. Arterioscler Thromb 1994; 14: 254-260.
25. Lindner V, Olson NE, Clowes AW, Reidy MA. Inhibition of smooth muscle cell proliferation in injured rat arteries. Interaction of heparin with basic fibroblast growth factor. J Clin Invest 1992; 90: 2044-2049.
26. Frebelius S, Isaksson S, Hedin U, Dryjski M, Swedenborg J. Antithrombin III mediated inhibition of thrombin induced proliferation in arterial smooth muscle cells: functional difference between antithrombin III isoforms. Thromb Haemost 1995; 73: 102.