Molecular genetics of the human MHC complement gene cluster

Experimental and Clinical Immunogenetics

Volumn 15, Issue 4, 1998, Pages 213-230

  Yu, C Yung ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b Wexner's Institute for Pediatric Research   (United States)

Author keywords

Complement C4 and C2 deficiencies; Endogenous retrovirus HERV K(C4); Novel genes DOM3Z, RD, RP1 and SKI2W; RCCX modular variation; Steroid 21 hydroxylase CYP21 and congenital adrenal hyperplasia; Tenascin TNX; Unequal crossover

Indexed keywords

COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C4; STEROID 21 MONOOXYGENASE; TENASCIN;

AMINO ACID SUBSTITUTION; COMPLEMENT DEFICIENCY; CONFERENCE PAPER; DISEASE ASSOCIATION; DNA POLYMORPHISM; FRAMESHIFT MUTATION; GENE CLUSTER; GENE DELETION; GENOME; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR GENETICS; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; PSEUDOGENE;

EID: 0032462768     PISSN: 02549670     EISSN: None     Source Type: Journal    
DOI: 10.1159/000019075     Document Type: Conference Paper

References (6)

1. Carroll MC, Campbell RD, Bentley DR, Porter RR: A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B. Nature 1984;307:237-241.
2. Aguado BMCM,Campbell RD: Genes of the MHC class III region and the functions of the proteins hey encode; in Browning M, McMichael A (eds): HLA and MHC: Genes, Molecules and Function. Oxford, BIOS Scientific Publishers, 1996, pp 39-75.
3. Higashi Y, Yoshioka H, Yamane M, Gotoh O, Fujii-Kuriyama Y: Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: A pseudogene and a genuine gene. Proc Natl Acad Sci USA 1986;83:2841-2845.
4. White PC, New MI, DuPont B: Structure of human steroid 21-hydroxylase genes. Proc Natl Acad Sci USA 1986;83:5111-5115.
5. Rodrigues NR, Dunham I, Yu CY, Carroll MC, Porter RR, Campbell RD: Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia. EMBO J 1987;6:1653-1661.
6. Morel Y, Bristow J, Gitelman SE, Miller WL: Transcript encoded on the opposite strand of the human steroid 21-hydroxylase/complement component C4 gene locus. Proc Natl Acad Sci USA 1989;86:6582-6586.