Late onset administration of oral antioxidants prevents age-related loss of motor co-ordination and brain mitochondrial DNA damage

Free Radical Research

Volumn 29, Issue 6, 1998, Pages 617-623

  Pallardo F V ^a   Asensi, M ^a   Garcia De La Asuncion J ^a   Anton V ^a   Lloret, A ^a   Sastre, J ^a   Vina J ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Aging; Brain; Motor co ordination; Oxidative stress

Indexed keywords

ANTIOXIDANT; DEOXYGUANOSINE DERIVATIVE; GLUTATHIONE; MITOCHONDRIAL DNA; SULFUR;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CELL PROTECTION; CONTROLLED STUDY; DNA DAMAGE; MOTOR COORDINATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS;

ANIMALIA;

EID: 0032462751     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715769800300671     Document Type: Article

References (30)

1. Harman, D. (1956). Aging: a theory based on free radical and radiation chemistry. Journal of Gerontology 11, 298-300.
2. Harman, D. (1981). The free radical theory of aging. Proceedings of the National Academy of Sciences of the United States of America 78, 7124-8.
3. Sies, H. (1986). Biochemistry of oxidative stress. Angewandte Chemie 25, 1058-71.
4. Harman, D. (1986). Free radical theory of aging: Role of free radicals in the origination and evolution of life, aging and disease processes. In: Free Radicals, Aging and Degenerative Diseases (Johnson, J.E., Jr., Walford, R., Harman D. and Miquel, J. eds.) New York: Alan R. Liss, pp. 3-49.
5. Viña, J., Sastre, J., Pallardó, F.V., Plá, R., Estrela, J.M. and Miquel, J. (1993). The mitochondrial theory of aging: recent developments. Bulletin of Molecular Biology 18, 81-87.
6. Orr, W.C. and Sohal, R.S. (1994). Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263, 1128-30.
7. Miquel, J., Economos, A.C., Fleming, J. and Johnson, J.E. Jr. (1980). Mitochondrial role in cell aging. Experimental Gerontology 15, 579-91.
8. Miquel, J., Fleming, J.E. (1986). Theoretical and experimental support for an "oxygen radical-mitochondrial injury" hypothesis of cell aging. In: Free Radicals, Aging and Degenerative Diseases (Johnson, J.E., Jr., Walford, R., Harman, D. and Miquel, J. eds.) New York: Alan R. Liss, pp. 51-74.
9. Shigenaga, M.K., Hagen, T.M. and Ames, B.N. (1994). Oxidative damage and mitochondrial decay in aging Proceedings of the National Academy of Sciences of the United States of America 91, 10771-8.
10. Sastre, J., Millán, A., García de la Asunción, J., Plá, R., Juan, G., Pallardó, F.V., O'Connor, E., Martin, J.A., Droy-Lefaix, M.T. and Viña, J. (1998). A Ginkgo biloba extract (EGb 761) prevents mitochondrial aging by protecting against oxidative stress. Free Radical Biology and Medicine 24(2), 298-304.
11. Forster, M.J., Dubey, A., Dawson, K.M., Stutts, W.A., Lal, H. and Sohal, R.S. (1996). Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain Proceedings of the National Academy of Sciences of the United States of America 93(10), 4765-9.
12. Viña, J., Perez, C., Furukawa, T., Palacín, M. and Viña, J.R. (1989). Effect of oral glutathione on hepatic glutathione levels. The British Journal of Nutrition 62, 683-91.
13. Viña, J., Sastre, J., Anton, V., Bruseghini, L., Esteras, A. and Asensi, M. (1992). Effect of aging on glutathione metabolism. Protection by antioxidants. In: Free Radicals and Aging (Emerit, I. and Chance, B., eds.) Birkhauser Verlag, Basel (Switzerland), pp. 136-144.
14. García de la Asunción, J., Millán, A., Plá, R., Bruseghini, L., Esteras, A., Pallardó, F.V., Sastre, J. and Viña, J. (1996). Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA. The FASEB Journal 10, 333-8.
15. Rickwood, D., Wilson, M.T. and Darley-Usmar, V.M. (1987). Isolation and characteristics of intact mitochondria. In: Mitochondria: A practical approach (Darley-Usmar, V.M., Rickwood, D., Wilson, M.T., eds.) Oxford: IRL Press Limited, pp. 1-16.
16. Miquel, J. and Blasco, M. (1978). A simple technique for evaluation of vitality loss in aging mice by testing their muscular coordination and vigor. Experimental Gerontololgy 13, 389-94.
17. Yen, T.C., Chen, Y.S., King, K.L., Yeh, S.H. and Wei, Y.H. (1989). Liver mitochondrial respiratory functions decline with age. Biochemical and Biophysical Research Communications 165(3), 994-1003.
18. Cutler, R.G. (1991) Antioxidants and aging. American Journal of Clinical Nutrition 53 (Suppl. 1), 373S-9S.
19. Furukawa, T., Meydani, S.N. and Blumberg, J.B. (1987). Reversal of age-associated decline in immune responsiveness by dietary glutathione supplementation in mice. Mechanisms of Aging Developments 38(2), 107-17.
20. Miquel, J. and Economos, A.C. (1979). Favorable effects of the antioxidants sodium and magnesium thiazolidine carboxylate on the vitality and life span of Drosophila and mice. Experimental Gerontology 14, 279-85.
21. Weindruch, R. and Walford, R.L. (1982). Dietary restriction in mice begining at one year of age: effects on life span and spontaneous cancer incidence. Science 215, 1415-7.
22. Alam, Z.I., Daniel, S.E., Lees, A.J., Marsden, D.C., Jenner, P. and Halliwell, B. (1997). A generalised increase in protein carbonyls in the brain in Parkinson's but not in incidental Lewy body disease. Journal of Neurochemistry 69, 1326-29.
23. Alam, Z.I., Jenner, A., Daniel, S.E., Lees, A.J., Cairns, N., Marsden, C.D., Jenner, P. and Halliwell, B. (1997). Oxidative DNA damage in the Parkinsonian brain: an apparent selective indrease in 8-hydroxyguanine levels in substantia nigra Journal of Neurochemistry 69, 1196-1203.
24. Coyle, J.T. and Puttfarken, P. (1993). Oxidative stress, glutamate and neurodegenerative disorders. Science 262, 689-95.
25. Sohal, R.S., Agarwal, S., Candas, M., Forster, M.J. and Lal, H. (1994) Effect of age and caloric restriction of DNA oxidative damage in different tissues of C57BL/6 mice. Mechanisms of Ageing and Development 76, 215-24.
26. Smith, C.D., Carney, J.M., Starke-Reed, P.E., Oliver, C.N., Stadtman, E.R., Floyd, R.A. and Markesbery, W.R. (1991). Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America, 88, 10540-3.
27. Perrig, W.J., Perrig, P. and Stähelin, H.B. (1997). The relation between antioxidants and memory performance in the old and very old. The Journal of the American Geriatric Society 45(6), 718-24.
28. Smith, M.A., Perry, G., Richey, P.L., Andreson, V.E., Beal, M.F. and Kowall, N. (1996). Oxidative damage in Alzheimer's. Nature 382, 120-1.
29. Gotz, M.E., Freyberger, A. and Riederer, P. (1990). Oxidative stress - A role of the pathogenesis of Parkinsons disease. Journal of Neural Transmission 29, 241-9.
30. Sano, M., Ernesto, C., Thomas, R.G., Klauber, M.R., Schaffer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C., Pfeiffer, E., Schneider, L.S. and Thal, L.J. (1997). A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The New England Journal of Medicine 337, 1216-22.